A5032370028- Drug-Induced Adverse Reactions
- Food Allergy and Anaphylaxis Research
- Contact Dermatitis and Allergies
- Pharmacovigilance and Adverse Drug Reactions
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Anesthesia and Sedative Agents
- Pharmaceutical studies and practices
- Airway Management and Intubation Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Acute Myocardial Infarction Research
- Dental Anxiety and Anesthesia Techniques
- Delphi Technique in Research
- Nausea and vomiting management
- Anesthesia and Pain Management
- Urticaria and Related Conditions
- Eosinophilic Esophagitis
- Foreign Body Medical Cases
- Autoimmune Bullous Skin Diseases
- Cardiac Imaging and Diagnostics
- Cutaneous lymphoproliferative disorders research
- Occupational exposure and asthma
- Abdominal Surgery and Complications
- Antibiotic Use and Resistance
- Cancer Treatment and Pharmacology
Leeds Teaching Hospitals NHS Trust
2017-2025
St James's University Hospital
2012-2025
University of Leeds
2020-2023
EES Research (United Kingdom)
2021
University of Novi Sad
2015
The Standards of Care Committee the British Society for Allergy and Clinical Immunology (BSACI) a committee experts key stakeholders have developed this guideline evaluation testing patients with an unsubstantiated label penicillin allergy. is intended UK clinicians who are not trained in allergy or immunology, but wish to develop de-labelling service their patients. It supplement BSACI 2015 "Management other beta-lactams" therefore does detail epidemiology aetiology allergy, as covered...
ObjectiveThe huge burden of inaccurate penicillin allergy labels (PALs) is an important driver antimicrobial resistance. This magnified by insufficient specialists and lack 'point-of-care' tests. We investigated the feasibility non-allergy healthcare professionals (HCPs) delivering direct oral challenges (DPCs) for de-labelling.MethodsThis prospective observational study was conducted in three hospitals England across settings (acute medical, pre-surgical haematology-oncology). Patients with...
Summary Peri‐operative anaphylaxis is a rare but potentially catastrophic event which must be considered whenever unexpected and significant cardiovascular or respiratory compromise occurs during anaesthesia. The Resuscitation Council UK algorithm for peri‐operative highlights the importance of early intravenous adrenaline fluid resuscitation provides guidance on treatment refractory immediate follow‐up. This endorsed by Royal College Anaesthetists, Association British Society Allergy...
ABSTRACT Background Removing inaccurate penicillin allergy labels (PALs) can reduce unnecessary exposure to ‘watch’ and ‘reserve’ groups of antibiotics thereby antimicrobial resistance. The most efficient model for a non‐allergy‐specialist‐led de‐labelling (PADL) service has not been established. Objective To determine the costs UK National Health Service direct oral challenge (DPC) low‐risk patients with PAL in three hospitals England, each different non‐allergy‐specialist delivery model:...
We describe an observational survey of diagnostic pathways in 104 patients attending four specialist allergy clinics the United Kingdom following perioperative hypersensitivity reactions to chlorhexidine reactions. The majority were life-threatening. Men undergoing urological or cardiothoracic surgery predominated. Skin prick testing and specific immunoglobulin (sIg)E most common tests used for diagnosis. Fifty-three per cent diagnoses made on basis a single positive test. Where multiple...
Some text in this abstract has been adapted from Krishna MT, Bhogal R, Ng BY, Kildonaviciute K, Jani YH, Williams I, et al . A multicentre observational study to investigate feasibility of a direct oral penicillin challenge de-labelling ‘low risk’ patients with allergy by non-allergy healthcare professionals (SPACE study): Implications for systems. J Infect 2024; 88 :106116. https://doi.org/10.1016/j.jinf.2024.01.015. This is an Open Access article distributed accordance the terms Creative...
Abstract Background Six percent of patients are allergic to penicillin according their medical records. While this designation protects a small number truly from serious reactions, those who incorrectly labelled may be denied access recommended first line treatment for many infections. Removal incorrect allergy have positive health consequences the individual and general population. We aimed explore primary care physicians’ (PCPs) patients’ views understanding with focus on clinical...