A5050518160- Drug-Induced Adverse Reactions
- Asthma and respiratory diseases
- Antifungal resistance and susceptibility
- Allergic Rhinitis and Sensitization
- Pharmacovigilance and Adverse Drug Reactions
- Antibiotic Use and Resistance
- Fungal Infections and Studies
- Food Allergy and Anaphylaxis Research
- Bacterial Identification and Susceptibility Testing
- Cystic Fibrosis Research Advances
- Patient Satisfaction in Healthcare
- Historical Medical Research and Treatments
- Pharmaceutical Practices and Patient Outcomes
- Antimicrobial Resistance in Staphylococcus
- Neonatal and Maternal Infections
- Pneumocystis jirovecii pneumonia detection and treatment
Oxford University Hospitals NHS Trust
2024-2025
University of Exeter
2024
Medical Research Council
2024
John Radcliffe Hospital
2021
University of Oxford
2021
Cambridge University Hospitals NHS Foundation Trust
2016
Addenbrooke's Hospital
2016
ObjectiveThe huge burden of inaccurate penicillin allergy labels (PALs) is an important driver antimicrobial resistance. This magnified by insufficient specialists and lack 'point-of-care' tests. We investigated the feasibility non-allergy healthcare professionals (HCPs) delivering direct oral challenges (DPCs) for de-labelling.MethodsThis prospective observational study was conducted in three hospitals England across settings (acute medical, pre-surgical haematology-oncology). Patients with...
ABSTRACT Background Removing inaccurate penicillin allergy labels (PALs) can reduce unnecessary exposure to ‘watch’ and ‘reserve’ groups of antibiotics thereby antimicrobial resistance. The most efficient model for a non‐allergy‐specialist‐led de‐labelling (PADL) service has not been established. Objective To determine the costs UK National Health Service direct oral challenge (DPC) low‐risk patients with PAL in three hospitals England, each different non‐allergy‐specialist delivery model:...
Some text in this abstract has been adapted from Krishna MT, Bhogal R, Ng BY, Kildonaviciute K, Jani YH, Williams I, et al . A multicentre observational study to investigate feasibility of a direct oral penicillin challenge de-labelling ‘low risk’ patients with allergy by non-allergy healthcare professionals (SPACE study): Implications for systems. J Infect 2024; 88 :106116. https://doi.org/10.1016/j.jinf.2024.01.015. This is an Open Access article distributed accordance the terms Creative...
The rising global tide of antimicrobial resistance is a well-described phenomenon. Employing effective and innovative stewardship strategies an essential approach to combat this public health threat. Education the patients paramount enable success such strategies. A panel hospital multidisciplinary healthcare professionals was set up short quiz containing true/false statements around designed piloted. An educational leaflet with correct replies supporting information also produced...
Background: Data on antifungal prescribing in neonatal patients are limited to either single-center or single-country studies 1-day recording. Therefore, we assessed longitudinal usage units (NUs) within Europe. Methods: CALYPSO, a prospective weekly point prevalence study drug NUs 18 hospitals (8 European countries), was conducted 2020 during 12-week period. All receiving systemic antifungals were included. Ward demographics collected at the beginning; ward and patient data including...
Over 95% of penicillin allergy labels are inaccurate and may be addressed in low-risk patients using direct oral challenge (DPC). This study explored the behaviour, attitudes acceptability patients, healthcare professionals (HCPs) managers DPC patients.
Abstract Introduction If antimicrobial resistance (AMR) is not controlled, a post-antibiotic era could result in common infections and minor injuries becoming fatal. One way to combat AMR the ‘de-labelling’ or removal of incorrect antibiotic allergy labels. At least 92% labels corresponding penicillin are when tested.[1] This means that patients may be receiving correct treatment take longer recover. Therefore, taking an accurate history important. Pharmacists routinely drug histories. From...