A5088116268- Neonatal Respiratory Health Research
- Infant Development and Preterm Care
- Neonatal and fetal brain pathology
- Neonatal and Maternal Infections
- Effects and risks of endocrine disrupting chemicals
- COVID-19 Impact on Reproduction
- Birth, Development, and Health
- Infant Nutrition and Health
- Maternal Mental Health During Pregnancy and Postpartum
- Preterm Birth and Chorioamnionitis
- Assisted Reproductive Technology and Twin Pregnancy
- Congenital Diaphragmatic Hernia Studies
- Telomeres, Telomerase, and Senescence
- Child and Adolescent Psychosocial and Emotional Development
- Congenital Anomalies and Fetal Surgery
- Toxic Organic Pollutants Impact
- Global Maternal and Child Health
- Ectopic Pregnancy Diagnosis and Management
- Parvovirus B19 Infection Studies
- Neuroscience of respiration and sleep
- Sepsis Diagnosis and Treatment
- Neonatal Health and Biochemistry
- Fetal and Pediatric Neurological Disorders
- Aluminum toxicity and tolerance in plants and animals
- Kawasaki Disease and Coronary Complications
University Hospital of Heraklion
2005-2025
University of Crete
2008-2025
University of Zurich
2024
Hippocration General Hospital
2024
The General Hospital of Heraklion "Venizeleio-Pananio"
2021
Agios Pavlos General Hospital
2021
European University Cyprus
2021
University of Cyprus
2021
The use of cerebral oximetry monitoring in the care extremely preterm infants is increasing. However, evidence that its improves clinical outcomes lacking. Download a PDF Research Summary. In this randomized, phase 3 trial conducted at 70 sites 17 countries, we assigned (gestational age, <28 weeks), within 6 hours after birth, to receive treatment guided by for first 72 birth or usual care. primary outcome was composite death severe brain injury on ultrasonography 36 weeks' postmenstrual...
Abstract The limited reserves of neutrophils are implicated in the susceptibility to infection neonates, however regulation neutrophil kinetics infections early life remains poorly understood. Here we show that developmental endothelial locus (DEL-1) is elevated neonates and critical for survival from neonatal polymicrobial sepsis, by supporting emergency granulopoiesis. Septic DEL-1 deficient neonate mice display low numbers myeloid-biased multipotent granulocyte-macrophage progenitors bone...
Phthalates are used in industry as plasticizers or additives everyday products and they have been considered endocrine disrupting chemicals. Maternal exposure during pregnancy has associated with neonatal exposure, preterm birth impacts the reproductive respiratory systems. The aim of this study is to determine six phthalate metabolites (mono isobutyl phthalate, miBP, mono n-butyl mnBP, benzyl mBzP, ethylhexyl mEHP, 2-ethyl-5-hydroxyhexyl mEHHP, 2-ethyl-5-oxohexyl-phthalate, mEOHP) amniotic...
Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infection and the resulting disease 2019 (COVID‑19) represented a global public health crisis most significant pandemic in modern times. Transmission characteristics, lack of effective antiviral treatment protocol protective vaccines, pushed healthcare systems, particularly intensive care units (ICUs), to their limits led extreme quarantine measures control pandemic. It was evident from an early stage that patient stratification...
To identify risk factors implicated in the development of periventricular leukomalacia (PVL) and to evaluate possible association between PVL with neonatal morbidity.Retrospective case control study.Medical records neonates admitted a University Hospital January 2000 December 2005.Sixty-nine born at gestational ages from 24 34 weeks. Forty-three these had cystic form (cPVL), whereas 26 transient echodensities (PVE).Each was matched for age year birth one control. The maternal medical were...
Preterm births constitute a major public health issue and chronic, cross-generational condition globally. Psychological biological factors interact in way that women from low socio-economic status (SES) are disproportionally affected by preterm delivery at increased risk for the development of perinatal mental problems. Low SES constitutes one most evident contributors to poor neurodevelopment infants. Maternal disorders have persistent effects on behavioral physiological functioning...
The aim of this study was to investigate whether the levels interleukin-6 (IL-6) can be used as markers adverse outcome in preterm neonates born after premature rupture membranes (PPROM).This involved 109 and their mothers. PPROM group consisted 58 who were PPROM, control 51 neonates. IL-6 measured umbilical cord blood, maternal blood sampled during delivery neonatal taken on fourth day life.In group, concentrations significantly higher with sepsis, compared those without sepsis (P < 0.001)....
Despite rapid advances in the management of preterm infants, periventricular leukomalacia (PVL) remains a considerable problem neonatal intensive care. The aim this study was to determine whether hypocarbia is associated with development PVL mechanically ventilated, infants and emphasize importance avoiding disturbance.The authors evaluated 52 ventilated gestational age <34 weeks, who exhibited first three postnatal days (lowest carbon dioxide tension being <25 mmHg). These were then...
Objective: To evaluate if the number of admitted extremely preterm (EP) infants (born before 28 weeks gestational age) differed in neonatal intensive care units (NICUs) SafeBoosC-III consortium during global lockdown when compared to corresponding time period 2019. Design: This is a retrospective, observational study. Forty-six out 79 NICUs (58%) from 17 countries participated. Principal investigators were asked report following information: (1) Total EP infant admissions their NICU 3 months...
Soon after the beginning of severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) pandemic in December, 2019, numerous research teams, assisted by vast capital investments, achieved vaccine development a fraction time. However, almost 8 months following initiation European vaccination programme, need for prospective monitoring vaccine‑induced immune response, its determinants and related side‑effects remains priority. The present study aimed to quantify response full with BNT162b2...
Background/Objectives: Limited data exist on the organization and operation of Level II/III Neonatal Intensive Care Units (NICUs) in Greece; this retrospective cross-sectional survey explored their structure functioning 2004 2022. Methods: A structured questionnaire was utilized, along with demographic perinatal obtained from Hellenic Statistical Authority. Results: Between 2022, live births decreased by 28%, while prematurity rate rose 6.96% to 11.87% (p < 0.001). Significant regional...
Background/Objectives: Postnatal growth faltering (PGF) significantly affects premature neonates, leading to compromised neurodevelopment and an increased risk of long-term health complications. Methods: This retrospective study at a level III NICU tertiary hospital analyzed 650 preterm neonates born before 33 weeks. was evaluated using the Fenton2013 INTERGROWTH-21st charts, with changes in weight z-scores from birth discharge classified as normal (ΔZ ≥ −1), non-severe PGF (−2 ≤ ΔZ <...
The worldwide prevalence of obesity continues to increase, representing a serious public health issue due associated comorbidities. Obesity is with type 2 diabetes mellitus (T2D), which shares similar pathophysiological mechanisms. In both conditions, oxidative stress, inflammation, mitochondrial dysfunction, abnormal adipose tissue function, and senescence are observed, ultimately leading insulin resistance. cases, hypertrophic telomere shortening. Elucidating the mechanisms underlying...
There are conflicting data concerning perinatal outcome of twin, in vitro fertilization (IVF) pregnancies. The aim this study was to evaluate and compare neonatal outcomes twin IVF pregnancies those spontaneously conceived gestations.The medical files 73 148 naturally were studied retrospectively. Data maternal characteristics, obstetric complications, recorded compared by chi2 test. one-way analysis variance (anova) used the means groups.Mean age, proportion nulliparous women, incidence...
Acute osteomyelitis (AO) in neonates, although rare, represents a diagnostic and therapeutic challenge. A high index of suspicion is necessary to make an early diagnosis, the observation clinical signs crucial. The increasing prevalence methicillin-resistant Staphylococcus aureus (MRSA) emerging problem pediatrics. In MRSA infections can cause wide spectrum diseases including bone joint infections. We report two cases AO full-term with no risk factors, due MRSA.
Monitoring the growth of neonates in Neonatal Intensive Care Unit (NICU) using charts constitutes an essential part preterm infant care. Preterm infants are at increased risk for extrauterine restriction (EUGR) due to energy needs and clinical complications. This retrospective study compares prevalence small gestational age (SGA) birth EUGR discharge extremely very hospitalized NICU a tertiary hospital Greece, different curves, it examines associated nutritional factors. Fenton2013...