A5008602419- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Neuroscience and Neuropharmacology Research
- Chemotherapy-induced organ toxicity mitigation
- Nigella sativa pharmacological applications
- Genomics, phytochemicals, and oxidative stress
- Anesthesia and Neurotoxicity Research
- Cancer Cells and Metastasis
- Cancer therapeutics and mechanisms
- Carcinogens and Genotoxicity Assessment
- Toxin Mechanisms and Immunotoxins
- Bee Products Chemical Analysis
- Mitochondrial Function and Pathology
- Toxic Organic Pollutants Impact
- Essential Oils and Antimicrobial Activity
- Electrochemical sensors and biosensors
- Moringa oleifera research and applications
- Cancer-related cognitive impairment studies
- Neuroblastoma Research and Treatments
- Circular RNAs in diseases
- Histone Deacetylase Inhibitors Research
- Tryptophan and brain disorders
- Cancer, Stress, Anesthesia, and Immune Response
- Microbial metabolism and enzyme function
- Cholinesterase and Neurodegenerative Diseases
Bilecik University
2022-2025
Atatürk University
2017-2022
(1) Background: Various epidemiological studies suggest that oxidative stress and disrupted neuronal function are mechanistically linked to neurodegenerative diseases (NDs), including Parkinson’s disease (PD) Alzheimer’s (AD). DNA damage, stress, lipid peroxidation, eventually, cell death such as NDs can be induced by nitrosamine-related compounds, leading neurodegeneration. A limited number of have reported exposure diethylnitrosamine (DEN), which is commonly found in processed/preserved...
High-grade gliomas are the most fatal brain tumors. Grade 4 called glioblastoma multiforme (GBM), which associated with poorest survival and a 5-year rate of less than 4%. Many patients GBM developed concomitant cognitive dysfunctions epilepsy. Although decline is well defined in glioblastomas, neurotoxic factors underlying this pathology not understood patients. In study, we aimed to investigate whether GBM-derived exosomes play role neuronal toxicity. For purpose, obtained from T98G U373...
Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infection and the resulting disease 2019 (COVID‑19) represented a global public health crisis most significant pandemic in modern times. Transmission characteristics, lack of effective antiviral treatment protocol protective vaccines, pushed healthcare systems, particularly intensive care units (ICUs), to their limits led extreme quarantine measures control pandemic. It was evident from an early stage that patient stratification...
Opioids can be used for medical and non-medical purposes. Chronic pain such as cancer, well the frequent use of drugs in places operating rooms intensive care units, areas like drug abuse effects side these need to examined more detail. For this purpose, fentanyl remifentanil on neuroinflammation, oxidative stress cholinesterase metabolism were investigated. Neuron cells (CRL-10742) evaluation toxicity remifentanil. MTT, PON1 activity total thiol levels its effect stress, AChE BChE...
Glutamate release and reuptake play a key role in the pathophysiology of depression. glutamatergic nerves hippocampus region are modulated by histaminergic afferents. Excessive accumulation glutamate synaptic area causes degeneration neuron cells. The H4 receptor is defined as main immune system histamine with pro-inflammatory role. To understand this receptor, drug JNJ7777120 was used to reveal chronic depression-glutamate relationship. We have important findings showing that antagonist...
(1) Background: Colon cancer is one of the most common types, and treatment options, unfortunately, do not continually improve survival rate patients. With unprecedented development nanotechnologies, nanomedicine has become a significant direction in research. Indeed, chemotherapeutics with nanoparticles (NPs) an outstanding new principle. (2) Methods: Fe3O4 NPs were synthesized characterized. Caco-2 colon cells treated during two different periods (24 72 h) (6 μg/mL), various concentrations...
Parkinson's disease (PD) is a chronic neurodegenerative case. As the progresses, response time to doses of levodopa (L-Dopa) becomes shorter and effects drug are severely limited by some undesirable side such as 'on–off' phenomenon. In several diseases, including Parkinson's, nanoparticles can deliver antioxidant compounds that reduce oxidative stress. This study evaluates compares neuroprotective L-Dopa-modified zinc (ZnNPs) in 6-hydroxydopamine (6-OHDA)-induced PD rat model. For this...
Methicillin‑resistant Staphylococcus aureus (MRSA) infections are usually found in hospital settings and, frequently, patients with open wounds. One of the most critical virulence factors affecting severity and recurrence is biofilm; increasing antibiotic resistance due to biofilm formation has led search for alternative compounds antibiotics. The present study aimed use boric acid potassium metaborate against MRSA infection a fibroblast wound model. For this purpose, two‑part experiment was...
Background: Nasal steroids are commonly prescribed in ear, nose, and throat clinics. It is observed that the use of nasal increasing due to prevalence allergic rhinitis. Because beclomethasone (BCM) toxicity low, it highly preferred The rate increases with increase duration dose BCM use. However, protective mechanism Anatolian propolis (AP) curcumin (Cur) against has not been fully explained. Aim: study evaluates potential BCM-induced effect on VEGF, MMP-2, IL-25, IL-10 parameters after Cur...
According to population-based studies, lung cancer is the prominent reason for cancer-related mortality worldwide in males and also rising females at an alarming rate. Sorafenib (SOR), which approved treatment of hepatocellular carcinoma renal cell carcinoma, a multitargeted protein kinase inhibitor. Additionally, SOR subject interest preclinical clinical trials cancer. This study was designed assess vivo possible effects sorafenib (SOR) diethylnitrosamine (DEN)-induced carcinogenesis...
Laryngeal squamous cell carcinoma (LSCC) is one of the most aggressive cancers, and its early diagnosis urgent. Exosomes are believed to have diagnostic significance in cancer. However, role serum exosomal microRNAs, miR-223, miR-146, miR-21, phosphatase tensin homologue (PTEN) hemoglobin subunit delta (HBD) mRNAs LSCC unclear. were isolated from blood 10 patients healthy controls perform scanning electron microscopy liquid chromatography quadrupole time-of-flight mass spectrometry analyses...
Glioblastoma multiforme (GBM) is a brain malignancy with worst survival. Low dose progesterone stimulates GBM growth, while receptor (PR)-antagonist mifepristone was shown to reduce growth and enhance temozolomide sensitivity in cells. Mifepristone not available all countries due ethical reasons may cause adrenal insufficiency pelvic infections. Ulipristal also PR-antagonist used treatment of uterine leiomyomas higher biosafety. demonstrated suppress breast cancer, yet it tested as whether...
Quinic acid (QA) is an alicyclic organic widely found in plants. It accumulates varying concentrations of plant species and actively metabolized throughout the plant's life cycle. Wound healing after skin injury involves a complex interaction many cells, fibroblasts, endothelial regenerated immune cells their interrelating extracellular matrix. In our study, effect QA on scar tissue was studied. For this aim, oxidative stress, changes FN1 Collogen1α gene levels were examined. purpose,...
Artificial azo dyes are widely used as coloring agents for foodstuffs, drugs and cosmetics. In this study, the toxic effect of four different synthetic food (Ponceau 4R, Sunset Yellow, Amaranth, Tartrazine) on 72±4h larvae Oregon (R) wild type Drosophila melanogaster were investigated. addition, depending chronic feeding, life span flies determined. For purpose, six concentrations (5, 10, 15, 20, 25 30 mg mL-1) selected by preliminary studies to determine LD100 values.The effects longevity...
The present study investigated the impact of boric acid (BA) and borax (BX) on markers inflammation modifications in miR‑21/PTEN/AKT pathway genes liver kidney tissues Sprague Dawley male rats with sepsis induced by cecal ligation puncture (CLP). A total 60 were randomly divided into 6 groups, each containing 10 animals as follows: Control, CLP (where model was created), 20 mg/kg BX (CLP + BX1), 40 BX2), BA BA1) BA2). Liver analyzed for histopathological changes, immunopositivity tumor...
Consumers are constantly exposed to a variety of chemical mixtures as part their everyday activities and lifestyle. Food, water commercial products only some examples the possible ways people get these mixtures. However, following federal local guidelines for risk assessment related exposure, analysis focuses on single substance exposure scenario not mixture, in real life. Realizing pronounced gap this methodology, real-life simulation approach tries address problem by investigating effect...
Hypertension, as a primary risk factor for many fatal disorders, is prevalent in the elderly. There wide literature on hypertension dealing with its biological and/or biochemical aspects; however, limited research available multifactorial nature of from mechanobiological standpoint. This study intended to parallel histopathological alterations and deviated protein expressions mechanical behavior hypertensive tissues. The Goldblatt (2K1C) method was chosen induction renovascular rabbits....
Excitotoxicity, caused by the excessive release of glutamate, leads to activation apoptotic process, making it a crucial factor in age-related neurodegenerative diseases. The aim this study was investigate potential nicorandil prevent glutamate excitotoxicity and reduce oxidative stress brain analyzing effects on primary cortex neurons. used neuron cultures from newborn Sprague-Dawley rats examine impact cell viability, Superoxide Dismutase, Catalase, Glutathione activity, Malondialdehyde...