A5011316528- Food Allergy and Anaphylaxis Research
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Eosinophilic Esophagitis
- Pediatric health and respiratory diseases
- Contact Dermatitis and Allergies
- Dermatology and Skin Diseases
- Gut microbiota and health
- Infant Health and Development
- Respiratory viral infections research
- Probiotics and Fermented Foods
- Immunodeficiency and Autoimmune Disorders
- Respiratory and Cough-Related Research
- Birth, Development, and Health
- Breastfeeding Practices and Influences
- Pneumonia and Respiratory Infections
- Infant Nutrition and Health
- IL-33, ST2, and ILC Pathways
- Child Nutrition and Feeding Issues
- Pregnancy-related medical research
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Viral gastroenteritis research and epidemiology
- Obesity, Physical Activity, Diet
- Neonatal Respiratory Health Research
The University of Melbourne
2016-2025
Royal Children's Hospital
2016-2025
Murdoch Children's Research Institute
2016-2025
Sun Yat-sen University
2020-2025
First Affiliated Hospital of Anhui Medical University
2025
Anhui Medical University
2025
South China Agricultural University
2025
McGill University
2025
Sichuan Agricultural University
2025
National University Hospital
2025
Beginning in 1970, a committee was constituted under the auspices of World Health Organization (WHO) to catalog primary immunodeficiencies. Twenty years later, International Union Immunological Societies (IUIS) took remit this committee. The current report details categorization and listing 354 (as February 2017) inborn errors immunity. growth increasing complexity field have been impressive, encompassing an variety conditions, classification described here will serve as critical reference...
We report the updated classification of primary immunodeficiency diseases, compiled by ad hoc Expert Committee International Union Immunological Societies. As compared to previous edition, more than 15 novel disease entities have been added in version. For each disorders, key clinical and laboratory features are provided. This is meant help diagnostic approach patients with these diseases.
Since the 1990s, International Union of Immunological Societies (IUIS) PID expert committee (EC), now called Inborn Errors Immunity Committee, has published every other year a classification inborn errors immunity. This complete catalog serves as reference for immunologists and researchers worldwide. However, it was unadapted clinicians at bedside. For those, IUIS EC is publishing phenotypical since 2013, which proved to be more user-friendly. There are 320 single-gene immunity underlying...
There is a lack of high-quality evidence based on the gold standard oral food challenges to determine allergy prevalence. Nevertheless, studies using surrogate measures allergy, such as health service utilization and clinical history, together with allergen-specific immunoglobulin E (sIgE), provide compelling data that prevalence increasing in both Western developing countries. In countries, challenge-diagnosed has been reported be high 10%, greatest noted among younger children. also...
Currently, testing for immunoglobulin E (IgE) sensitization is the cornerstone of diagnostic evaluation in suspected allergic conditions. This review provides a thorough and updated critical appraisal most frequently used tests, both
Autosomal recessive interleukin-1 receptor-associated kinase (IRAK)-4 and myeloid differentiation factor (MyD)88 deficiencies impair Toll-like receptor (TLR)- receptor-mediated immunity. We documented the clinical features outcome of 48 patients with IRAK-4 deficiency 12 MyD88 deficiency, from 37 kindreds in 15 countries. The were indistinguishable. There no severe viral, parasitic, fungal diseases, range bacterial infections was narrow. Noninvasive occurred 52 patients, a high incidence...
Human interleukin (IL) 1 receptor–associated kinase 4 (IRAK-4) deficiency is a recently discovered primary immunodeficiency that impairs Toll/IL-1R immunity, except for the Toll-like receptor (TLR) 3– and TLR4–interferon (IFN)-a/b pathways. The clinical immunological phenotype remains largely unknown. We diagnosed up to 28 patients with IRAK-4 deficiency, tested blood TLR responses individual leukocyte subsets, multiple cytokines. patients' peripheral mononuclear cells (PBMCs) did not induce...
The relationship between early onset eczema and food allergy among infants has never been examined in a population-based sample using the gold standard for diagnosis, oral challenge.We characterised risk of challenge-proven with general population.One-year-old (n = 4453 meeting criteria this analysis) were assessed history eczema, received nurse-administered examination underwent skin prick testing to peanut, egg sesame. Those detectable wheal one test foods an challenge irrespective size....
BackgroundEpidemiological evidence has shown that pediatric food allergy is more prevalent in regions further from the equator, suggesting vitamin D insufficiency may play a role this disease.ObjectiveTo investigate of status infantile allergy.MethodsA population sample 5276 one-year-old infants underwent skin prick testing to peanut, egg, sesame, and cow's milk or shrimp. All those with detectable wheal random participants negative test results attended hospital-based challenge clinic....
<b>Objective:</b> To estimate the overall incidence of acute and overuse volleyball injuries, to describe factors associated with ankle sprains. <b>Methods:</b> 486 players from second third Dutch national divisions participated in study were followed prospectively during a whole season. Three measurements made season (baseline, follow up 1, 2), where all completed questionnaire on demographic variables (only at baseline), sports participation, use preventive measures, previous injuries....
It is generally accepted that the prevalence of food allergy has been increasing in recent decades, particularly westernised countries, yet high-quality evidence based on challenge confirmed diagnosis to support this assumption lacking because high cost and potential risks associated with conducting challenges large populations. Accepting caveat, use surrogate markers for (such as nationwide data hospital admissions anaphylaxis or clinical history combination allergen-specific IgE (sIgE)...
Measurement of whole peanut-specific IgE (sIgE) is often used to confirm sensitization but does not reliably predict allergy. Ara h 2 the dominant peanut allergen detected in 90% 100% patients with allergy and could help improve diagnosis.We sought determine whether testing might accuracy diagnosing therefore circumvent need for an oral food challenge (OFC).Infants from population-based HealthNuts study underwent skin prick tests subsequently a OFC status. In stratified random sample 200...