A5016217164- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Bacterial Infections and Vaccines
- COVID-19 Clinical Research Studies
- Influenza Virus Research Studies
- Cervical Cancer and HPV Research
- Vaccine Coverage and Hesitancy
- Pneumocystis jirovecii pneumonia detection and treatment
- Asthma and respiratory diseases
- Immunodeficiency and Autoimmune Disorders
- SARS-CoV-2 detection and testing
- Food Allergy and Anaphylaxis Research
- Probiotics and Fermented Foods
- Hepatitis B Virus Studies
- Immunotherapy and Immune Responses
- Neonatal Respiratory Health Research
- Gut microbiota and health
- Immune Cell Function and Interaction
- Genomics, phytochemicals, and oxidative stress
- Histone Deacetylase Inhibitors Research
- Long-Term Effects of COVID-19
- Streptococcal Infections and Treatments
- Viral gastroenteritis research and epidemiology
- Eosinophilic Esophagitis
Murdoch Children's Research Institute
2016-2025
The University of Melbourne
2016-2025
Royal Children's Hospital
2014-2025
Menzies School of Health Research
2014-2024
London School of Hygiene & Tropical Medicine
2021-2024
Institut Pasteur in Ho Chi Minh City
2024
Duke-NUS Medical School
2024
Peter Doherty Institute
2021-2022
Institute of Infection and Immunity
2021
Parks Victoria
2021
Histone deacetylase (HDAC) inhibitors are an emerging class of therapeutics with potential as anticancer drugs. The rationale for developing HDAC (and other chromatin-modifying agents) therapies arose from the understanding that in addition to genetic mutations, epigenetic changes such dysregulation enzymes can alter phenotype and gene expression, disturb homeostasis, contribute neoplastic growth. family is large diverse. It includes a range naturally occurring synthetic compounds differ...
Measurement of whole peanut-specific IgE (sIgE) is often used to confirm sensitization but does not reliably predict allergy. Ara h 2 the dominant peanut allergen detected in 90% 100% patients with allergy and could help improve diagnosis.We sought determine whether testing might accuracy diagnosing therefore circumvent need for an oral food challenge (OFC).Infants from population-based HealthNuts study underwent skin prick tests subsequently a OFC status. In stratified random sample 200...
Abstract The hallmarks of COVID-19 are higher pathogenicity and mortality in the elderly compared to children. Examining baseline SARS-CoV-2 cross-reactive immunological responses, induced by circulating human coronaviruses (hCoVs), is needed understand such divergent clinical outcomes. Here we show analysis coronavirus antibody responses pre-pandemic healthy children ( n = 89), adults 98), 57), patients 50) systems serology. Moderate levels cross-reactive, but non-neutralizing, antibodies...
<h3>Importance</h3> The immune response in children with SARS-CoV-2 infection is not well understood. <h3>Objective</h3> To compare seroconversion nonhospitalized and adults mild identify factors that are associated seroconversion. <h3>Design, Setting, Participants</h3> This household cohort study of collected weekly nasopharyngeal throat swabs blood samples during the acute (median, 7 days for 12 [IQR, 4-13] days) convalescent 41 31-49] periods after polymerase chain reaction (PCR)...
To cite this article: Boyle RJ, Ismail IH, Kivivuori S, Licciardi PV, Robins‐Browne RM, Mah L‐J, Axelrad C, Moore Donath Carlin JB, Lahtinen SJ, Tang MLK. Lactobacillus GG treatment during pregnancy for the prevention of eczema: a randomized controlled trial. Allergy 2011; 66 : 509–516. Abstract Background: Probiotic supplementation in early life may be effective preventing eczema. Previous studies have suggested that prenatal administration particularly important beneficial effects....
Abstract Background: Alterations in intestinal microflora have been linked to the development of allergic disease. Recent studies suggest that healthy infant immune may depend on establishment a diverse gut microbiota rather than presence or absence specific microbial strains. Objectives: We investigated relationship between diversity early postnatal period and subsequent eczema atopy first year life. Methods: Fecal samples were collected 1 wk after birth from 98 infants at high risk...
The prevalence of allergic disease has increased dramatically in Western countries over the past few decades. hygiene hypothesis, whereby reduced exposure to microbial stimuli early life programs immune system toward a Th2-type response, is suggested be major mechanism explain this phenomenon developed populations. Such exposures are recognized critical regulators intestinal microbiota development. Furthermore, an important role signaling developing mucosal system. Intestinal dysbiosis been...
Compared to adults, children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have predominantly mild or asymptomatic infections, but the underlying immunological differences remain unclear. Here, we describe clinical features, virology, longitudinal cellular, and cytokine immune profile, SARS-CoV-2-specific serology salivary antibody responses in a family of two parents PCR-confirmed symptomatic SARS-CoV-2 infection their three children, who tested repeatedly PCR negative....
The current global novel coronavirus disease 2019 (COVID-19) pandemic threatens to derail the uptake of human papillomavirus (HPV) vaccination in low- and lower-middle income countries with major disruptions routine immunization introduction new vaccines delayed. This has a impact on World Health Organization cervical cancer elimination strategy, where it is dependent HPV as well screening treatment. We discuss opportunities barriers achieve high COVID-19. Implementation 4 key...
As the establishment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T cell memory in children remains largely unexplored, we recruited convalescent COVID-19 and adults to define their circulating SARS-CoV-2-specific CD4
Changes in diet can also have dramatic effects on the composition of gut microbiota. Commensal bacteria gastrointestinal tract are critical regulators health and disease by protecting against pathogen encounter whilst maintaining immune tolerance to certain allergens. Moreover, consumption fibre vegetables typical a non-Western generates substantial quantities short-chain fatty acids (SCFAs) which potent anti-inflammatory properties. Dietary interventions such as probiotic supplementation...
Vitamin D induces a diverse range of biological effects, including important functions in bone health, calcium homeostasis and, more recently, on immune function. The role vitamin during infection is particular interest given data from epidemiological studies suggesting that deficiency associated with an increased risk infection. has immunomodulatory functions, although its bacterial remains unclear. In this study, we examined the effects 1,25(OH)₂D₃, active metabolite D, peripheral blood...
Streptococcus pyogenes causes at least 750 million infections and more than 500,000 deaths each year. No vaccine is currently available for S. the use of human challenge models offer unique exciting opportunities to interrogate immune response infectious diseases. Here, we high-dimensional flow cytometric analysis multiplex cytokine chemokine assays study serial blood saliva samples collected during early in participants following with pyogenes. We find an signature experimental pharyngitis...
Age can profoundly affect susceptibility to a broad range of human diseases. Children are more susceptible some infectious diseases such as diphtheria and pertussis, while in others, coronavirus disease 2019 hepatitis A, they protected compared with adults. One explanation is that the composition immune system major contributing factor severity. While most studies have focused on adults, how changes after birth remains poorly understood. Here, using high-dimensional spectral flow cytometry...
Vγ9Vδ2 T cells are the largest population of γδ in adults and can play important roles providing effective immunity against cancer infection. Many studies have suggested that peripheral derived from fetal liver thymus postnatal plays little role development these cells. More recent evidence may also develop postnatally thymus. Here, we used high-dimensional flow cytometry, transcriptomic analysis, functional assays, precursor-product experiments to define pathway We identify three distinct...
The intestinal microbiota plays an important role in immune development and homeostasis. A disturbed during early infancy is associated with increased risk of developing inflammatory allergic diseases later life. mechanisms underlying these effects are poorly understood but likely to involve alterations microbial production fermentation-derived metabolites, which have potent modulating properties required for maintenance healthy mucosal responses. Probiotics beneficial bacteria that the...
Both genetic and epigenetic factors are important regulators of the immune system. There is an increasing body evidence attesting to modifications that influence development distinct innate adaptive response cells. Chromatin remodelling via acetylation, methylation, phosphorylation, ubiquitination histone proteins as well DNA, methylation mechanisms by which gene expression can be controlled. In this paper, we will discuss role epigenetics in regulation host immunity, with particular...