A5045914613- Immunodeficiency and Autoimmune Disorders
- Food Allergy and Anaphylaxis Research
- Infant Health and Development
- Infant Nutrition and Health
- Probiotics and Fermented Foods
- Dermatology and Skin Diseases
- Pediatric health and respiratory diseases
- Immune responses and vaccinations
- Gut microbiota and health
- Asthma and respiratory diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Allergic Rhinitis and Sensitization
- Renal Diseases and Glomerulopathies
- Cystic Fibrosis Research Advances
- Identification and Quantification in Food
- Adolescent and Pediatric Healthcare
- Vitamin D Research Studies
- Platelet Disorders and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Protein Hydrolysis and Bioactive Peptides
- Milk Quality and Mastitis in Dairy Cows
- Bee Products Chemical Analysis
- Immune Cell Function and Interaction
- Pediatric Urology and Nephrology Studies
- Vasculitis and related conditions
Universiti Putra Malaysia
2016-2025
Damascus University
2025
Universiti Teknologi MARA
2021-2023
Hospital Sungai Buloh
2021-2022
Murdoch Children's Research Institute
2010-2016
The University of Melbourne
2011-2016
To cite this article: Boyle RJ, Ismail IH, Kivivuori S, Licciardi PV, Robins‐Browne RM, Mah L‐J, Axelrad C, Moore Donath Carlin JB, Lahtinen SJ, Tang MLK. Lactobacillus GG treatment during pregnancy for the prevention of eczema: a randomized controlled trial. Allergy 2011; 66 : 509–516. Abstract Background: Probiotic supplementation in early life may be effective preventing eczema. Previous studies have suggested that prenatal administration particularly important beneficial effects....
Abstract Background: Alterations in intestinal microflora have been linked to the development of allergic disease. Recent studies suggest that healthy infant immune may depend on establishment a diverse gut microbiota rather than presence or absence specific microbial strains. Objectives: We investigated relationship between diversity early postnatal period and subsequent eczema atopy first year life. Methods: Fecal samples were collected 1 wk after birth from 98 infants at high risk...
Prevention guidelines for infants at high risk of allergic disease recommend hydrolysed formula if is introduced before 6 months, but evidence mixed. Adding specific oligosaccharides may improve outcomes.To evaluate whether partially whey containing (0.8 g/100 ml) (pHF-OS) can prevent eczema in high-risk [ISRCTN65195597].We conducted a parallel-group, multicentre, randomized double-blind controlled trial pHF-OS vs standard cow's milk formula. Infants with family history were (stratified by...
Abstract Background An altered compositional signature and reduced diversity of early gut microbiota are linked to development allergic disease. We investigated the relationship between dominant Bifidobacterium species during post‐natal period subsequent disease in first year life. Methods Faecal samples were collected at age 1 week, month 3 months from 117 infants high risk analysed by quantitative PCR terminal restriction fragment length polymorphism. Infants examined 3, 6 12 months, skin...
Despite perennial sunshine, vitamin D deficiency is prevalent among Malaysians especially pregnant women. This study determines the status and its associated factors third trimester women attending government health clinics in Selangor Kuala Lumpur, Malaysia.Information on socio-demographic characteristics, obstetrical history, sun exposure were obtained through face-to-face interviews. Vitamin intake was assessed using a semi-quantitative food frequency questionnaire (FFQ). Serum...
Introduction and importance: Truncus arteriosus type I is an uncommon congenital heart anomaly distinguished by the presence of a single arterial trunk emanating from heart, resulting in mixing oxygenated deoxygenated blood. Timely surgical intervention crucial to segregate pulmonary systemic circulations for improved prognoses. Case presentation: This report details 19-year-old male presenting with chronic cyanosis, digital clubbing, diagnosis Eisenmenger syndrome. Laboratory evaluations...
To cite this article: Ismail IH, Oppedisano F, Joseph SJ, Boyle RJ, Robins‐Browne RM, Tang MLK. Prenatal administration of Lactobacillus rhamnosus has no effect on the diversity early infant gut microbiota. Pediatric Allergy Immunology 2012: 23 : 255–258. Abstract We have recently shown that maternal GG (LGG) during late pregnancy can beneficial effects development microbiota, promoting a bifidobacteria profile similar to healthy breastfed infant. It is uncertain, however, whether such...
The goal of allergic rhinitis (AR) management is to achieve satisfactory symptom control ensure good quality life. Most patients with AR are currently treated pharmacotherapy. However, knowledge gaps on the use pharmacotherapy still exist among physicians, particularly in primary care setting, despite availability guideline recommendations. Furthermore, it common for physicians secondary setting express uncertainty regarding new combination therapies like intranasal corticosteroid plus...
Background: RAS guanyl-releasing protein 1 (RASGRP1) deficiency is characterized by immune dysregulation and Epstein–Barr virus (EBV)-related lymphoproliferation. Diffuse mesangial sclerosis one of the infrequent causes infantile nephrotic syndrome.
The chemical (proximate, amino acid, fatty acid) and mineral composition of raw goat milk from British Alpine, Jamnapari, Saanen, Shami, Toggenburg breed (n= 30) were investigated. results showed a significant difference (p< .05) on the between breeds. Principal component analysis (PCA) grouped breeds into three groups; Saanen Alpine Toggenburg. This study that can be used as criteria to classify These findings important for breeder manufacturer improve their products using selection.
Abstract Introduction The overall beneficial effects of breastfeeding for infants have been well documented, but its role in allergy prevention is controversial. Objective We investigated the relationship between breast milk immunomodulatory factors and subsequent development eczema atopic sensitization first year life. Methods Day 7 28 samples were collected from mothers carrying at high risk allergic disease. Aqueous‐phase assayed TGF ‐β1, sCD 14 total I g A . Infants assessed presence 12...
Probiotics are defined as live micro-organisms that when administered in adequate amounts confer a health benefit on the host. Among their pleiotropic effects, inhibition of pathogen colonization at mucosal surface well modulation immune responses widely recognized principal biological activities probiotic bacteria. In recent times, effects probiotics have led to application vaccine adjuvants, offering novel strategy for enhancing efficacy current vaccines. Such an approach is particularly...
The role of gut microbiota in early life and its impact on health subsequent diseases remain unclear. There is a lack research awareness this area, especially the Asia-Pacific region, including Malaysia. This paper reports position Malaysian Working Group some key issues surrounding diseases, as well experts' stand probiotics prebiotics. group reached consensus that certain factors, elective caesarean; premature deliveries; complementary feeding; use antibiotics, prebiotics and/or...
Allergic diseases are the most common chronic illness in childhood. Findings from developed countries have reported associations between Vitamin D levels during pregnancy and offspring allergy risk. This prospective cohort study aimed to determine maternal late allergic Malaysian infants first year of life. Serum 25(OH)D concentrations 380 pregnant women third trimester were measured using a chemiluminescent immunoassay. Children’s outcomes assessed at 3, 6, 12 months based on parental...
Abstract Background Regulatory T cells (Treg) play an essential role in early immune programming and shaping the response towards a pro‐allergic or tolerant state. We evaluated cord blood Treg cytokine responses to microbial non‐microbial stimuli infants at high risk of allergic disease their associations with development first year. Methods Cord mononuclear from 72 neonates were cultured toll‐like receptors ( TLR 2) ligands: lipoteichoic acid LTA ) heat‐killed Lactobacillus rhamnosus GG HKL...
Introduction With increased diagnostic capabilities and treatment modalities in the field of primary immunodeficiencies (PID), many pediatric patients survive beyond childhood experience a change care to adult-oriented healthcare system. Unfortunately, transition pathways for PID are less clearly defined, resulting deterioration quality adulthood. Hence, this is first regional study address clinicians’ opinions on practices challenges 7 Southeast Asia (SEA) countries. Methods We adopted...
Nutrition and environmental factors are essential for the education of neonatal immune system. Epidemiological evidence has shown that malnutrition allergic diseases occur during early childhood share similar protective risk factors. This paper describes protocol Mother Infant Cohort Study (MICOS), which aims to determine contribution nutrition development in infants' first year life.MICOS is a prospective cohort study conducted at selected government health clinics two states, namely...
Primary Immunodeficiency Disease (PID), also known as Inborn Errors of Immunity (IEI), comprises a group rare genetic disorders that impair the body's immune responses. These conditions result from monogenic germline mutations affect function genes governing innate and adaptive system. Therefore, individuals with PID are more susceptible to infectious diseases, allergies, autoimmune autoinflammatory conditions. The prevalence has been on rise, number classified diseases reaching 404, 430...
Two-dimensional electrophoretic (2DE)-based proteomics remains a powerful tool for allergenomic analysis of goat’s milk but requires effective extraction proteins to accurately profile the overall causative allergens. However, there are several current issues with analysis, and among these absence established standardized method proteomes complexity matrix that may hamper efficacy protein extraction. This study aimed evaluate efficacies three different methods, qualitatively quantitatively,...
Primary immunodeficiency diseases (PIDs) are chronic that affect the various aspects of a patient's life. However, impact living with PIDs is poorly described.This study aimed to explore experience challenges among Malaysian caregivers patients PID who underwent follow-up in Universiti Sains Malaysia or those registered members Society.The was conducted from March 1 May 30, 2021. The parents children were invited participate for semi-structured in-depth interview at clinics USM. estimated...