Sophie E. Moore
A5064618891- Child Nutrition and Water Access
- Birth, Development, and Health
- Infant Nutrition and Health
- Breastfeeding Practices and Influences
- Infant Development and Preterm Care
- Iron Metabolism and Disorders
- Pregnancy and preeclampsia studies
- Epigenetics and DNA Methylation
- Child Nutrition and Feeding Issues
- Gestational Diabetes Research and Management
- Poverty, Education, and Child Welfare
- Obesity, Physical Activity, Diet
- Neonatal and fetal brain pathology
- Global Maternal and Child Health
- Child and Adolescent Psychosocial and Emotional Development
- Folate and B Vitamins Research
- Heavy Metal Exposure and Toxicity
- Traffic Prediction and Management Techniques
- Climate Change and Health Impacts
- Health, Environment, Cognitive Aging
- Digestive system and related health
- Viral gastroenteritis research and epidemiology
- Gut microbiota and health
- Bullying, Victimization, and Aggression
- Pediatric health and respiratory diseases
King's College London
2016-2025
London School of Hygiene & Tropical Medicine
2016-2025
MRC Unit the Gambia
2016-2025
Medical Research Council
2012-2024
Tampere University Hospital
2024
Sheffield Hallam University
2024
Tampere University
2024
Harvard University
2013-2024
Insper
2024
Monash University
2024
Abstract In experimental animals, maternal diet during the periconceptional period influences establishment of DNA methylation at metastable epialleles in offspring, with permanent phenotypic consequences. Pronounced naturally occurring seasonal differences rural Gambian women allowed us to test this humans. We show that significant variations methyl-donor nutrient intake mothers around time conception influence 13 relevant plasma biomarkers. The level several these biomarkers predicts...
Aflatoxins are immunotoxins that frequently contaminate staple foods in The Gambia and other parts of sub-Saharan Africa, resulting high exposure throughout life. Impaired infant immune system development may be a key predictor mortality from infectious disease. In this study we aimed to determine the effect dietary aflatoxin on number parameters Gambian children. A cohort 472 children 6-9 years age was recruited. Serum aflatoxin-albumin (AF-alb) adducts were analyzed provide measure...
Background: Human milk is a complex fluid comprised of myriad substances, with one the most abundant substances being group carbohydrates referred to as human oligosaccharides (HMOs). There has been some evidence that HMO profiles differ in populations, but few studies have rigorously explored this variability. Objectives: We tested hypothesis diverse populations healthy women. Next, we examined relations between and maternal anthropometric reproductive indexes indirectly whether differences...
Abstract Human milk oligosaccharides (HMOs) play an important role in the health of infant as substrate for beneficial gut bacteria. Little is known about effects HMO composition and its changes on morbidity growth outcomes infants living areas with high infection rates. Mother’s microbiota from 33 Gambian mother/infant pairs at 4, 16, 20 weeks postpartum were analyzed relationships between HMOs, microbiota, growth. The data indicate that lacto- N -fucopentaose I was associated decreased...
Background Microbial communities in human milk and those feces from breastfed infants vary within across populations. However, few researchers have conducted cross-cultural comparisons between populations, little is known about whether certain "core" taxa occur normally or populations variation microbiome related to infant fecal microbiome. The purpose of this study was describe microbiomes produced by relatively healthy women living at diverse international sites compare these the their...
Sustainable Development Goal 2.2-to end malnutrition by 2030-includes the elimination of child wasting, defined as a weight-for-length z-score that is more than two standard deviations below median World Health Organization standards for growth
Globally, 149 million children under 5 years of age are estimated to be stunted (length more than 2 standard deviations below international growth standards)
Abstract Growth faltering in children (low length for age or low weight length) during the first 1,000 days of life (from conception to 2 years age) influences short-term and long-term health survival 1,2 . Interventions such as nutritional supplementation pregnancy postnatal period could help prevent growth faltering, but programmatic action has been insufficient eliminate high burden stunting wasting low- middle-income countries. Identification windows population subgroups on which focus...
BACKGROUND: Research over the past decade has suggested that prenatal and early postnatal nutrition influence risk of developing chronic degenerative diseases up to 60 years later. We now present evidence death from infectious in young adulthood is similarly programmed by life events. METHODS: In three rural Gambian villages, affected a marked annual seasonality diet disease, we have kept detailed demographic, anthropometric health records since 1949. Fate was known with certainty for 3,162...
BackgroundArsenic (As) exposure during pregnancy induces oxidative stress and increases the risk of fetal loss low birth weight.ObjectivesIn this study we aimed to elucidate effects As on immune markers in placenta cord blood, involvement stress.MethodsPregnant women were enrolled around gestational week (GW) 8 our longitudinal, population-based, mother–child cohort Matlab, an area rural Bangladesh with large variations concentrations well water. Women (n = 130) delivering at local clinics...
To cite this article: Boyle RJ, Ismail IH, Kivivuori S, Licciardi PV, Robins‐Browne RM, Mah L‐J, Axelrad C, Moore Donath Carlin JB, Lahtinen SJ, Tang MLK. Lactobacillus GG treatment during pregnancy for the prevention of eczema: a randomized controlled trial. Allergy 2011; 66 : 509–516. Abstract Background: Probiotic supplementation in early life may be effective preventing eczema. Previous studies have suggested that prenatal administration particularly important beneficial effects....
Abstract Background Interindividual epigenetic variation that occurs systemically must be established prior to gastrulation in the very early embryo and, because it is systemic, can assessed easily biopsiable tissues. We employ two independent genome-wide approaches search for such variants. Results First, we screen metastable epialleles by performing genomewide bisulfite sequencing peripheral blood lymphocyte (PBL) and hair follicle DNA from Caucasian adults. Second, conduct a genomic...
<h3>Background</h3> The natural history of chronic HBV infection in sub-Saharan Africa is unknown. Data are required to inform WHO guidelines that currently based on studies Europe and Asia. <h3>Methods</h3> Between 1974 2008, serosurveys were repeated two Gambian villages, an open cohort treatment-naive carriers was recruited. Participants followed estimate the rates hepatitis B e (HBeAg) surface antigen (HBsAg) clearance incidence hepatocellular carcinoma (HCC). In 2012–2013, a...