A5004624020- Child Nutrition and Water Access
- Child Nutrition and Feeding Issues
- Global Maternal and Child Health
- Birth, Development, and Health
- Infant Nutrition and Health
- Poverty, Education, and Child Welfare
- Pregnancy and preeclampsia studies
- Infant Development and Preterm Care
- Food Security and Health in Diverse Populations
- Iron Metabolism and Disorders
- Breastfeeding Practices and Influences
- Malaria Research and Control
- Viral gastroenteritis research and epidemiology
- Obesity, Physical Activity, Diet
- Gestational Diabetes Research and Management
- Maternal Mental Health During Pregnancy and Postpartum
- Neonatal Respiratory Health Research
- Child and Adolescent Health
- HIV Research and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Gut microbiota and health
- Pregnancy and Medication Impact
- Fatty Acid Research and Health
- HIV/AIDS Research and Interventions
- Hemoglobinopathies and Related Disorders
Tampere University
2016-2025
Tampere University Hospital
2016-2025
World Health Organization
2018-2024
International Centre for Diarrhoeal Disease Research
2013-2023
London School of Hygiene & Tropical Medicine
2023
University of Toronto
2017-2022
Faculty of Public Health
2020
World Health Organization - Pakistan
2018
Helsinki University Hospital
2016
University of Ghana
2014-2015
Undernourished children exhibit impaired development of their gut microbiota. Transplanting microbiota from 6- and 18-month-old healthy or undernourished Malawian donors into young germ-free mice that were fed a diet revealed immature infants transmit growth phenotypes. The representation several age-discriminatory taxa in recipient animals correlated with lean body mass gain; liver, muscle, brain metabolism; bone morphology. Mice cohoused shortly after receiving severely stunted underweight...
Gut bacterial strains targeted by IgA in undernourished Malawian children produce severe enteropathy gnotobiotic mice and correlate with health status.
Abstract The I nternational L ipid‐ B ased N utrient S upplements ( iLiNS ) P roject began in 2009 with the goal of contributing to evidence base regarding potential lipid‐based nutrient supplements LNS prevent undernutrition vulnerable populations. first project objective was development acceptable products for infants 6–24 months and pregnant lactating women, use studies three countries urkina F aso, G hana M alawi). This paper shares rationale a series decisions supplement formulation...
Globally, 149 million children under 5 years of age are estimated to be stunted (length more than 2 standard deviations below international growth standards)
Abstract Growth faltering in children (low length for age or low weight length) during the first 1,000 days of life (from conception to 2 years age) influences short-term and long-term health survival 1,2 . Interventions such as nutritional supplementation pregnancy postnatal period could help prevent growth faltering, but programmatic action has been insufficient eliminate high burden stunting wasting low- middle-income countries. Identification windows population subgroups on which focus...
The WHO Model List of Essential Medicines (EML) prioritizes medicines that have significant global public health value. EML can also deliver important messages on appropriate medicine use. Since 2017, in response to the growing challenge antimicrobial resistance, antibiotics were reviewed and categorized into three groups: Access, Watch Reserve, leading a new categorization called AWaRe. These categories developed taking account impact different classes implications for their 2023 AWaRe...
It is plausible that one of the key biological pathways through which Kangaroo mother care (KMC) improves health outcomes in LBW infants by enhancing human milk intake and quality. This hypothesis needs to be tested. To estimate effect promotion support KMC compared control during neonatal period on components. We randomized 550 (1500-2250 grams) intervention arm with for continuous skin-to-skin contact exclusive breastfeeding home visits or no such (control) period. All received routine...
The activity of the human immunodeficiency virus (HIV) protease is essential for processing gag-pol precursor proteins and maturation infectious virions. We have prepared a peptidomimetic inhibitor, U-75875, that inhibited HIV-1 protein in an essentially irreversible manner. Noninfectious particles produced presence drug contained gag precursors were morphologically immature. In peripheral blood mononuclear cells continuous cell line, U-75875 completely blocked HIV replication; latter case,...
Human immunodeficiency virus (HIV) infects human cells by binding to surface CD4 molecules and directly fusing with the cell membrane. Although mouse expressing bind HIV, they do not become infected, apparently because of a block in membrane fusion. To study this problem, we constructed recombinant vaccinia that can infect promote transient expression full-length mammalian cells. This virus, together another encoding biologically active HIV envelope glycoprotein gp160, allowed us...
The intestinal microbiota composition in infants reflects the early environment. Our objective was to compare gut 6-month-old living rural Malawi with children of same age urban Finland, both being breast-fed and having an age-appropriate diet typical for each area.Malawian (n=44) were compared Finnish (n=31) age. In cohorts, infant stool samples available characterization by flow cytometry-fluorescent situ hybridization quantitative polymerase chain reaction methods.Bifidobacteria dominant...
<h3>Objective</h3> To compare growth and incidence of malnutrition in infants receiving long-term dietary supplementation with ready-to-use fortified spread (FS) or micronutrient-fortified maize–soy flour (likuni phala [LP]). <h3>Design</h3> Randomized, controlled, single-blind trial. <h3>Setting</h3> Rural Malawi. <h3>Participants</h3> A total 182 six-month-old infants. <h3>Intervention</h3> Participants were randomized to receive 1 year daily 71 g LP (282 kcal), 50 FS (FS50) (256 25 (FS25)...