A5015749292- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Pharmaceutical Economics and Policy
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Practices and Patient Outcomes
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Pharmaceutical Quality and Counterfeiting
- Natural product bioactivities and synthesis
- Tuberculosis Research and Epidemiology
- Veterinary medicine and infectious diseases
- Microbial Natural Products and Biosynthesis
- Nosocomial Infections in ICU
- Bacterial Genetics and Biotechnology
- Tannin, Tannase and Anticancer Activities
- Mycobacterium research and diagnosis
- Global Maternal and Child Health
- Clostridium difficile and Clostridium perfringens research
- CRISPR and Genetic Engineering
- Healthcare Systems and Reforms
- Pharmaceutical studies and practices
- Bacteriophages and microbial interactions
World Health Organization
2017-2024
University College London
2014
University of London
2011
The WHO Model List of Essential Medicines (EML) prioritizes medicines that have significant global public health value. EML can also deliver important messages on appropriate medicine use. Since 2017, in response to the growing challenge antimicrobial resistance, antibiotics were reviewed and categorized into three groups: Access, Watch Reserve, leading a new categorization called AWaRe. These categories developed taking account impact different classes implications for their 2023 AWaRe...
Despite ongoing efforts to stimulate investment and research into the development of new antibiotics, clinical pipeline remains insufficient, in particular treat critical resistant Gram-negative bacterial infections. The two reports released by World Health Organization on preclinical antibacterial show that current is very dry dominated derivatives existing classes. There are only 32 antibacterials target WHO priority pathogens, which 6 fulfill at least 1 innovation criteria as defined WHO....
Surfactant-mediated removal of proteins from biomembranes invariably results in partial or complete loss function and disassembly multi-protein complexes. We determined the capacity styrene-co-maleic acid (SMA) co-polymer to remove components cell division machinery membrane drug-resistant staphylococcal cells. SMA-lipid nanoparticles solubilized FtsZ-PBP2-PBP2a complexes intact cells, demonstrating close physical proximity these within lipid bilayer. Exposure bacteria (-)-epicatechin...
The pipeline of new antibacterials remains limited. Reasons include low research investments, limited commercial prospects, and scientific challenges. To complement existing initiatives such as grants, governments are exploring policy options for providing market incentives to drug developers. Reimbursement interventions in France, Germany, Sweden, US, UK were reviewed analysed by the authors. In implemented centre on exceptions cost-containment mechanisms allow higher prices certain...
Antimicrobial stewardship (AMS) has emerged as a systematic approach to optimize antimicrobial use and reduce resistance. To support the implementation of AMS programs, World Health Organization developed draft toolkit for health care facility programs in low- middle-income countries. A feasibility study was conducted Bhutan, Federated States Micronesia, Malawi, Nepal obtain local input on content programs. This descriptive qualitative included semi-structured interviews with national-...
The clinical pipeline continues to be insufficient contain antimicrobial resistance, and further investment research is needed ensure that a robust built treat the WHO priority pathogens list of antibiotic-resistant bacteria. To shed light upstream on preclinical has undertaken review antibacterial published data all identified projects in publicly accessible database. database captures 252 unique agents development being developed by 145 individual institutions, which majority are smaller...