A5083242205- Vibrio bacteria research studies
- Antibiotic Resistance in Bacteria
- SARS-CoV-2 and COVID-19 Research
- COVID-19 epidemiological studies
- Antibiotic Use and Resistance
- SARS-CoV-2 detection and testing
- Salmonella and Campylobacter epidemiology
- Infections and bacterial resistance
- COVID-19 Clinical Research Studies
- Aquaculture disease management and microbiota
- Global Maternal and Child Health
- COVID-19 Pandemic Impacts
- Mosquito-borne diseases and control
- Neonatal and Maternal Infections
- Microbial Community Ecology and Physiology
- Genetics, Bioinformatics, and Biomedical Research
- Enterobacteriaceae and Cronobacter Research
- Infection Control in Healthcare
- Biotechnology and Related Fields
- Genomics and Phylogenetic Studies
- Influenza Virus Research Studies
- Pharmaceutical Practices and Patient Outcomes
- Bacterial biofilms and quorum sensing
Public Health Institute of Malawi
2019-2024
Ministry of Health
2019-2024
Zambia National Public Health Institute
2022
University of KwaZulu-Natal
2022
Stellenbosch University
2022
Malawi experienced its deadliest Vibrio cholerae (Vc) outbreak following devastating cyclones, with >58,000 cases and >1700 deaths reported between March 2022 May 2023. Here, we use population genomics to investigate the attributes origin of 2022-2023 Vc isolates. Our results demonstrate predominance ST69 clone, also known as seventh cholera pandemic El Tor (7PET) lineage, expressing O1 Ogawa (~ 80%) serotype followed by Inaba 16%) sporadic non-O1/non-7PET serogroups 4%). Phylogenetic...
Antimicrobial resistance (AMR) is becoming a critical public health issue globally. The World Health Organization launched the Global Resistance and Use Surveillance System (GLASS) to support strengthening of AMR evidence base.The article describes evolution national surveillance systems data reporting countries in African continent between 2017 2019, constraints, perceived impact value participation GLASS.Data on implementation rates were submitted GLASS 2019 summarised though descriptive...
Antimicrobial stewardship (AMS) has emerged as a systematic approach to optimize antimicrobial use and reduce resistance. To support the implementation of AMS programs, World Health Organization developed draft toolkit for health care facility programs in low- middle-income countries. A feasibility study was conducted Bhutan, Federated States Micronesia, Malawi, Nepal obtain local input on content programs. This descriptive qualitative included semi-structured interviews with national-...
Despite ongoing containment and vaccination efforts, cholera remains prevalent in many countries sub-Saharan Africa. Part of the difficulty containing comes from our lack understanding how it circulates throughout region. To better characterize regional transmission, we generated analyzed 118
In line with global instruments, within the last five years, two-thirds of all countries in WHO Africa Region (WHO AFR) have developed a National Action Plan (NAP) on Antimicrobial Resistance (AMR). We sought to evaluate progress made across implementing NAP for effective response AMR. A semi-structured survey tool was administered obtain information from national focal persons implementation strategic elements This followed by Lessons Learnt Workshop June 2019 at Douala, Cameroon, where...
Purpose. Carbapenemase-producing Enterobacteriaceae (CPE) have become a global concern and serious threat to human health due their resistance multiple antibiotics. In this study, we identified characterized CPE for the first time in Malawi, southeastern Africa.Methodology. We investigated possible presence of carbapenemases among collection 200 ceftriaxone-nonsusceptible Gram-negative clinical isolates obtained from five Malawian hospitals between January 2016 December 2017, using both...
In response to a cholera outbreak among mobile, difficult-to-reach fishermen on Lake Chilwa, Malawi in 2016, novel vaccine distribution strategy exploited the proven thermostability. Fishermen, while taking first dose under supervision, received second sealed bag, and were told drink it two weeks later. This study assessed short-term protection of this strategy.Patients with diarrhoea admitted health facilities around lake interviewed stool sample collected for PCR testing. Vaccine...
Abstract Malawi is experiencing its deadliest Vibrio cholerae ( Vc ) outbreak following devastating cyclones, with >58,000 cases and >1,700 deaths reported between March 2022 May 2023. Here, we use population genomics to investigate the attributes origin of 2022– 2023 isolates. Our results demonstrate predominance ST69 seventh cholera pandemic El Tor (7PET) strains expressing O1 Ogawa (∼80%) serotype followed by Inaba (∼16%) typical non-outbreak-associated non-O1/non-ST69 serotypes...
The B.1.1.529 (Omicron) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in the fourth COVID-19 pandemic wave across southern African region, including Malawi. seroprevalence SARS-CoV-2 antibodies and their association with epidemiological trends hospitalisations deaths are needed to aid locally relevant public health policy decisions.
Abstract Rapid diagnostic tests (RDTs) for cholera are an important emerging tool surveillance, yet the currently available have several limitations. We assess performance of a new RDT, Cholkit, during outbreak in Malawi compared with culture and find sensitivity 93.0% (95% CI, 83.0%–98.1%) specificity 95.7% 78.1%–100.0%).
Global estimates for cholera annually approximate 4 million cases worldwide with 95,000 deaths. Recent outbreaks, including Haiti and Yemen, are reminders that is still a global health concern. Cholera outbreaks can rapidly induce high death tolls by overwhelming the capacity of facilities, especially in remote areas or civil unrest. studies demonstrated stool specimens preserved on filter paper facilitate molecular analysis Vibrio cholerae resource limited settings. Specimens rapid,...
Stenotrophomonas maltophilia is a significant opportunistic pathogen that associated with high mortality in immunocompromised individuals. In this study, we describe multidrug-resistant (MDR) S. clinical isolate from Kamuzu Central Hospital (KCH), Lilongwe, Malawi.A ceftriaxone and meropenem nonsusceptible (Sm-MW08), recovered December 2017 at KCH, was referred to the National Microbiology Reference Laboratory for identification. April 2018, identified using MALDI Biotyper mass spectrometry...
<title>Abstract</title> Policy and decision-makers are increasingly interacting with complex science as the momentum for evidence-informed decision-making grows. Unfortunately, often, have not been equipped optimally this interaction, so may understand, communicate, or use data information appropriately, at all. This leads to missed opportunities improve health society outcomes, in worst case scenarios, lead risky decisions, if results misinterpreted miscommunicated. In study, we explored...
Abstract Background The B.1.1.529 (Omicron) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in the fourth COVID-19 pandemic wave across southern African region, including Malawi. seroprevalence SARS-CoV-2 antibodies and their association with epidemiological trends hospitalisations deaths are needed to aid locally relevant public health policy decisions. Methods We conducted a population-based serosurvey from December 27, 2021 January 17, 2022, 7...