A5051540175- Child Nutrition and Water Access
- Global Maternal and Child Health
- Malaria Research and Control
- Infant Nutrition and Health
- Mosquito-borne diseases and control
- Poverty, Education, and Child Welfare
- Viral gastroenteritis research and epidemiology
- Child Nutrition and Feeding Issues
- Birth, Development, and Health
- Maternal and Neonatal Healthcare
- Digestive system and related health
- Iron Metabolism and Disorders
- Fatty Acid Research and Health
- Gut microbiota and health
- Cardiovascular Health and Disease Prevention
- Respiratory viral infections research
- Parasitic Infections and Diagnostics
- Hepatitis Viruses Studies and Epidemiology
- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- Blood Pressure and Hypertension Studies
- COVID-19 Impact on Reproduction
- Dental Radiography and Imaging
- Body Composition Measurement Techniques
- Bariatric Surgery and Outcomes
Kamuzu Central Hospital
2022-2025
Kamuzu University of Health Sciences
2022-2025
University of Health Science
2024
University of Malawi
2012-2022
Tampere University
2013-2019
Tampere University Hospital
2014-2019
The intestinal microbiota composition in infants reflects the early environment. Our objective was to compare gut 6-month-old living rural Malawi with children of same age urban Finland, both being breast-fed and having an age-appropriate diet typical for each area.Malawian (n=44) were compared Finnish (n=31) age. In cohorts, infant stool samples available characterization by flow cytometry-fluorescent situ hybridization quantitative polymerase chain reaction methods.Bifidobacteria dominant...
Low nutritional value of complementary foods is associated with high incidence childhood growth stunting in low-income countries. This study was done to test a hypothesis that dietary complementation lipid-based nutrient supplements (LNS) promotes linear and reduces the severe among at-risk infants. A total 840 6-month-old healthy infants rural Malawi were enrolled randomised assessor-blinded trial. The participants received 12-month supplementation nothing, milk-LNS, soy-LNS, or corn-soy...
Abstract Background Tracking of early motor development is essential for all neurodevelopmental assessments. A multisensor wearable system, MAIJU (Motor Assessment Infants with a JUmpsuit), was recently developed an objective and scalable measurement developing skills in out-of-hospital settings. Here, we assessed its feasibility remote low-resource Methods We recruited 44 infants repeated at-home measurements (total N = 121) the rural Malawi. (i) technical quality measured data, (ii)...
We aimed to understand the mortality risks of vulnerable newborns (defined as preterm and/or born weighing smaller or larger compared a standard population), in low- and middle-income countries (LMICs).Descriptive multi-country, secondary analysis individual-level study data babies since 2000.Sixteen subnational, population-based studies from nine LMICs sub-Saharan Africa, Southern Eastern Asia, Latin America.Live birth neonates.We categorically defined five newborn types based on size...
Primary Health Care (PHC) is a strategy endorsed for attaining equitable access to basic health care including treatment and prevention of endemic diseases. Thirty four years later, its implementation remains sub-optimal in most Sub-Saharan African countries that interventions still major challenge large proportion the rural population. Community-directed with ivermectin (CDTi) community-directed (CDI) are participatory approaches strengthen at community level. Both based on values...
Abstract Background Control of malaria parasite transmission can be enhanced by understanding which human demographic groups serve as the infectious reservoirs. Because vector biting heterogeneous, some infected individuals may contribute more to human-to-mosquito than others. Infection prevalence peaks in school-age children, but it is not known how often they are fed upon. Genotypic profiling blood permits identification individual humans who were bitten. The present investigation used...
Abstract Objective To describe the mortality risks by fine strata of gestational age and birthweight among 230 679 live births in nine low‐ middle‐income countries (LMICs) from 2000 to 2017. Design Descriptive multi‐country secondary data analysis. Setting Nine LMICs sub‐Saharan Africa, Southern Eastern Asia, Latin America. Population Liveborn infants 15 population‐based cohorts. Methods Subnational, studies with high‐quality birth outcome were invited join Vulnerable Newborn Measurement...
As countries of sub-Saharan Africa expand irrigation to improve food security and foster economic growth, it is important quantify the malaria risk associated with this process. Irrigated ecosystems can be increased risk, but relationship not fully understood. We studied at Bwanje Valley Irrigation Scheme (800 hectares) in Malawi. Household prevalence indoor Anopheles density were quantified two cross-sectional studies 2016 2017 (5,829 residents 1,091 households). Multilevel logistic...
Abstract Objective To examine prevalence of novel newborn types among 541 285 live births in 23 countries from 2000 to 2021. Design Descriptive multi‐country secondary data analysis. Setting Subnational, population‐based birth cohort studies ( n = 45) low‐ and middle‐income (LMICs) spanning 2000–2021. Population Liveborn infants. Methods with high‐quality outcome LMICs were invited join the Vulnerable Newborn Measurement Collaboration. We defined distinct using gestational age (preterm [PT],...
A novel qualitative point-of-care test of activated matrix metalloproteinase-8 (aMMP-8) using noninvasive oral rinse sampling procedures has been developed for the early detection collagen breakdown indicating periodontal tissue destruction. The main object this study was to assess reliability in a low-income setting identify participants with history destruction detected as alveolar bone loss (ABL) radiographs. This cross-sectional included 486 women who had recently delivered rural Malawi....
To examine whether two forms of lipid-based nutrient supplements (LNS) or a micronutrient-fortified corn-soya blend were associated with development the gut microbiota in Malawian infants, to assess profiles at age 6 and 18 months follow changes during 12-month period.This was substudy 4-arm randomised controlled trial conducted rural Malawi. Infants receive no supplement primary follow-up period (control), 54 g/day LNS milk protein base (milk LNS), soya (soya 71 for 12 months. Stool samples...
Malawi is a malaria-endemic country and approximately 6 million cases are reported annually. Improving knowledge of malaria causes symptoms, the overall perception towards its preventive measures vital for control. The current study investigated levels causes, symptoms prevention among Malawian women.Data from 2017 wave Malaria Indicator Survey (MMIS) were analysed. In total, 3422 women reproductive age (15-49 years) sampled women's about: (1) malaria; (2) and, (3) assessed. tertiles...
Three human protoparvoviruses, bufavirus (BuV), tusavirus (TuV) and cutavirus (CuV), have recently been discovered in diarrheal stool. BuV has associated with diarrhea CuV cutaneous T-cell lymphoma, but there are hardly any data for TuV or stool respiratory samples. Hence, using qPCR IgG enzyme immunoassays, we analyzed 1072 stool, 316 445 serum plasma samples from 1098 patients without gastroenteritis (GE) respiratory-tract infections (RTI) Finland, Latvia Malawi. The overall CuV-DNA...
Over the last two decades, many countries have moved from malaria control toward elimination. However, some sub-Saharan African countries, like Malawi, recently seen a reversal in progress with reported increases confirmed cases. This may be result of inadequate access to effective interventions by key population groups that perpetuate transmission. study aimed assess barriers accessing treatment among school-aged children (SAC) Malawi.
Abstract Enteric pathogens have been related to child undernutrition. Whereas there are lots of data on enteric bacterial microbiota and infections, much less is known about the incidence prevalence intestinal colonisation with viruses or important parasitic species. This study assessed presence selected parasites in stools 469, 354, 468 Malawian children at 6, 12 18 months. We also environmental predictors among 6-month infants. Microbial was documented using real-time polymerase chain...
We showed earlier that presumptive infection treatment in pregnancy reduced the prevalence of neonatal stunting a rural low-income setting. In this article, we assess how these gains were sustained and reflected childhood growth, development, mortality.We enrolled 1320 pregnant Malawian women randomized trial treated them for malaria other infections with either 2 doses sulfadoxine-pyrimethamine (SP) (control), monthly SP, or azithromycin (AZI-SP). Child height length mortality recorded at...
Abstract Aim Despite high pathogen burden and malnutrition in low‐income settings, knowledge on relationship between asymptomatic viral or parasitic infections, nutrition growth is insufficient. We studied these relationships a cohort of six‐month‐old Malawian infants. Methods As part nutrient supplementation trial for 12 months, we documented disease symptoms 840 participant daily anthropometric measurements every three months. Stool specimens were collected six months analysed Giardia...
ABSTRACT Objectives: The aim of the study was to assess effect nutritional supplementation with lipid‐based nutrient supplements (LNS) and corn‐soy blend flour on Bifidobacterium Staphylococcus aureus gut microbiota composition in Malawian infants. In addition, changes over time were characterized Methods: Healthy 6‐month‐old infants randomly assigned 1 4 intervention schemes for a 6‐month period. Infants control group not provided any supplementary food. other 3 groups received either...
Despite the scale-up of interventions against malaria over past decade, this disease remains a leading threat to health in Malawi. To evaluate epidemiology both Plasmodium falciparum infection and disease, Malawi International Center Excellence for Malaria Research (ICEMR) has developed implemented diverse robust surveillance research projects. Descriptive studies ICEMR Phase 1 increased our understanding declining effectiveness long-lasting insecticidal nets (LLINs), role school-age...
To assess whether using lipid-based nutrient supplements (LNS) to complement the diets of infants and young children affected when they achieved selected developmental milestones.In rural Malawi, 840 6-month-old healthy were enrolled a randomised trial. Control participants received no supplements, others provided with milk-containing LNS, soy-containing LNS or corn-soy blend (CSB) for 12 months. Outcomes age at which key milestone: motor (walking assistance, standing walking alone,...