A5041410476- Infant Nutrition and Health
- Breastfeeding Practices and Influences
- Child Nutrition and Water Access
- Digestive system and related health
- Pharmaceutical and Antibiotic Environmental Impacts
- Gut microbiota and health
- Probiotics and Fermented Foods
- Neonatal Respiratory Health Research
- Effects and risks of endocrine disrupting chemicals
- Glycosylation and Glycoproteins Research
- Genomics and Phylogenetic Studies
- Pediatric health and respiratory diseases
- Reproductive biology and impacts on aquatic species
- Marine and coastal ecosystems
- Ophthalmology and Visual Health Research
- Pharmacological Effects and Assays
- Retinal Imaging and Analysis
- Carbohydrate Chemistry and Synthesis
- Glutathione Transferases and Polymorphisms
- Ophthalmology and Visual Impairment Studies
University of California, Davis
2014-2023
Seattle University
2012
Attempts to alter intestinal dysbiosis via administration of probiotics have consistently shown that colonization with the administered microbes is transient. This study sought determine whether provision an initial course Bifidobacterium longum subsp. infantis (B. infantis) would lead persistent probiotic organism in breastfed infants. Mothers intending breastfeed were recruited and provided lactation support. One group mothers fed B. EVC001 their infants from day 7 28 life (n = 34), second...
Abstract Human milk oligosaccharides (HMOs) play an important role in the health of infant as substrate for beneficial gut bacteria. Little is known about effects HMO composition and its changes on morbidity growth outcomes infants living areas with high infection rates. Mother’s microbiota from 33 Gambian mother/infant pairs at 4, 16, 20 weeks postpartum were analyzed relationships between HMOs, microbiota, growth. The data indicate that lacto- N -fucopentaose I was associated decreased...
Abstract The infant intestinal microbiota is often colonized by two subspecies of Bifidobacterium longum : subsp. infantis ( B. ) and ). Competitive growth in the neonate intestine has been linked to utilization human milk oligosaccharides (HMO). However, little known how consumes HMO. In this study, infant-borne strains exhibited varying HMO phenotypes. While all efficiently utilized lacto- N- tetraose, certain additionally metabolized fucosylated SC596 grew vigorously on HMO,...
Glycans in breast milk are abundant and found as either free oligosaccharides or conjugated to proteins lipids. Free human (HMOs) function prebiotics by stimulating the growth of beneficial bacteria while preventing binding harmful intestinal epithelial cells. Bacteria have adapted glycan-rich environment gut developing enzymes that catabolize glycans. The decrease HMOs increase glycan digestion products give indications active microbial population. In this study, we quantitated...
Human milk oligosaccharides (HMOs) and bioactive breast proteins have many beneficial properties. Information is sparse regarding associations between these constituents infant growth development in lower-income countries.
The aim of this study was to measure consumption and absorption human milk oligosaccharides (HMOs) in a cohort premature infants treated with probiotic Bifidobacterium breve.Twenty-nine (median gestational age 28 weeks, range 23-32 weeks) cared for the neonatal intensive care unit King Edward Princess Margaret Hospital Perth, Australia, were B breve at dose 1.66 billion organisms per day. Samples feces, urine, obtained initiation again 3 weeks later. 16S ribosomal RNA from feces analyzed by...
Mass spectrometry-based glycome analysis is a viable strategy for the compositional and functional exploration of glycosylation. However, lack generic tools high-throughput reliable glycan spectral interpretation largely hampers broad usability glycomic research. Here, we developed tool, GlycoNote, comprehensive precise analysis. GlycoNote supports tandem-mass spectrometry data from any sample source, uses novel target-decoy method with iterative decoy searching highly result output, embeds...
In surface waters, two of the most commonly observed androgenic steroid hormones are androstenedione (AD) and testosterone (T). This study compares photodegradation dilute (<10 μg L(-1)) aqueous solutions AD T in natural sunlight, evaluates endocrine-disrupting potential resulting solutions. also examines effect dissolved organic matter (DOM) on photodegradation. During spring summer at Henderson, NV, USA (latitude 36.04°N), underwent direct photodegradation, with half-lives ranging from 3.7...
Human milk enriches members of the genus Bifidobacterium in infant gut. One species, pseudocatenulatum, is found gastrointestinal tracts adults and breastfed infants. In this study, B. pseudocatenulatum strains were isolated characterized to identify genetic adaptations During growth on pooled human oligosaccharides (HMOs), we observed two distinct groups isolates that readily consumed HMOs those did not, a difference driven by variable catabolism fucosylated HMOs. A conserved gene cluster...
Isoflavones are plant-derived chemicals that potential endocrine disruptors. Although some recent studies have detected isoflavones in natural waters, little is known about their aquatic fates. The photochemical behaviors of the daidzein, formononetin, biochanin A, genistein, and equol were studied under simulated solar light sunlight. All these phytoestrogens found to be photolabile certain conditions. Daidzein formononetin degraded primarily by direct photolysis. Their expected...
Human milk oligosaccharides (HMOs) and bioactive proteins are beneficial to infant health. Recent evidence suggests that maternal nutrition may affect the amount of HMOs in breast milk; however, effect nutrient supplementation on has not yet been well studied. We aimed determine whether lipid-based supplements (LNSs) protein HMO concentrations at 6 mo postpartum women rural Malawi. These secondary outcomes a previously published randomized controlled trial. Women were randomly assigned...
Infant fecal samples are commonly studied to investigate the impacts of breastfeeding on development microbiota and subsequent health effects. Comparisons infants living in different geographic regions environmental contexts needed aid our understanding evolutionarily-selected milk adaptations. However, preservation from individuals remote locales until they can be processed a challenge. Freeze-drying (lyophilization) offers cost-effective way preserve some biological for transport analysis...
Human milk oligosaccharides (HMOs) and bioactive proteins likely benefit infant health, but information on these relations is sparse. We aimed to examine associations of content HMOs with incidence longitudinal prevalence morbidity (any illness, fever, diarrhea, acute respiratory infection, loss appetite) markers inflammation [C-reactive protein (CRP) α-1-acid glycoprotein (AGP)]. These are secondary analyses a randomized controlled trial. Breast samples at 6 mo postpartum (n = 659) were...
Aim: To analyze the demographic and clinical profile of patients attending low vision clinic a tertiary eye care facility in Kerala. Materials Methods: This was cross-sectional observational study at Kerala between May 2007 2016. Information regarding characteristics rehabilitation done were recorded. Results: Out total 916 new patients, 51.31% males 48.69% females. Thirty-three percent above 60 years, 26.24% 40 16.11% 17 35 years. Mean age 51.2 ± 23.5 Major etiological diseases age-related...