A5027156310- Infant Nutrition and Health
- Neonatal Respiratory Health Research
- Breastfeeding Practices and Influences
- Cytomegalovirus and herpesvirus research
- SARS-CoV-2 and COVID-19 Research
- Pregnancy and preeclampsia studies
- Cancer, Lipids, and Metabolism
- Child Nutrition and Water Access
- Diabetes and associated disorders
- Metabolomics and Mass Spectrometry Studies
- Advanced Proteomics Techniques and Applications
- Viral gastroenteritis research and epidemiology
- Birth, Development, and Health
University of California, Davis
2021-2023
Introduction Human milk oligosaccharides (HMOS) are indigestible carbohydrates that support infant development by establishing a healthy microbiota, preventing infectious diseases, and promoting immune cognitive development. Individual HMOS have distinct functions based on their chemical structures. HMO profiles can vary largely among mothers, but the research factors other than genetic background affecting composition limited. Methods In present analysis, we examined relationships between...
Glycans on the host cell membrane and viral proteins play critical roles in pathogenesis. Highly glycosylated epithelial cells represent primary boundary separating embedded tissues from pathogens within respiratory intestinal tracts. SARS-CoV-2, causative agent for COVID-19 pandemic, reaches into tract. We found purified human milk oligosaccharides (HMOs) inhibited binding cells. Spike (S) protein receptor domain (RBD) to were partly blocked by co-incubation with exogenous HMOs, most...
Abstract Human milk oligosaccharides (HMOs) support the development of a healthy gut microbiome and growth infants. We aimed to determine association different HMOs with severe acute malnutrition (SAM) among Bangladeshi young This study was nested within single-blind, randomized, pilot clinical trial (NCT0366657). A total 45 breastmilk samples from mothers < 6 months old infants who had SAM (n = 26) or were non-malnourished 19) analyzed for constituent HMOs. Of SAM, 14 (53.85%) secretor...
In this work, we developed a targeted glycoproteomic method to monitor the site-specific glycoprofiles and quantities of most abundant HDL-associated proteins using Orbitrap LC-MS for (glyco)peptide target discovery QqQ quantitative analysis. We conducted pilot study workflow determine whether HDL protein are altered in healthy human participants response dietary glycan supplementation.