A5090607267- Gastric Cancer Management and Outcomes
- Lung Cancer Research Studies
- Diet and metabolism studies
- Glycosylation and Glycoproteins Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer Immunotherapy and Biomarkers
- Neuroinflammation and Neurodegeneration Mechanisms
- Pancreatic and Hepatic Oncology Research
- Gut microbiota and health
- Immunotherapy and Immune Responses
- Cardiac Arrest and Resuscitation
- Adipose Tissue and Metabolism
- Medical Research and Treatments
- Regional Development and Environment
- MicroRNA in disease regulation
- Alzheimer's disease research and treatments
- Cancer, Lipids, and Metabolism
- Nutrition, Genetics, and Disease
- Mechanical Circulatory Support Devices
- Lipoproteins and Cardiovascular Health
- Immune cells in cancer
- Cardiac Structural Anomalies and Repair
- Cancer Cells and Metastasis
- Esophageal Cancer Research and Treatment
- Lysosomal Storage Disorders Research
University of California, Davis
2020-2025
Qingdao University
2024-2025
Wuhan University
2021-2025
Nanjing Medical University
2016-2025
Shandong University of Traditional Chinese Medicine
2024-2025
Zhongnan Hospital of Wuhan University
2022-2025
Affiliated Hospital of Qingdao University
2025
Inner Mongolia University of Technology
2025
Jiangnan University
2025
State Key Laboratory of Food Science and Technology
2025
Abstract Minimally invasive thermal therapies have been attempted in the treatment of breast cancer, and immune response induced by these has not fully reported. A clinical trial is performed to determine effect microwave ablation (MWA) early‐stage cancer. The authors perform single‐cell RNA sequencing on peripheral blood mononuclear cells (PBMCs) from six patients before after ablation. NK CD8 + T are activated MWA with increased inhibitory signature but dysfunctional. Enhanced...
Glycosylation has been found to be altered in the brains of individuals with Alzheimer's disease (AD). However, it is unknown which specific glycosylation-related pathways are AD dementia. Using publicly available RNA-seq datasets covering seven brain regions and including 1724 samples, we identified genes ubiquitously changed AD. Several differentially expressed glycosyltransferases by were confirmed qPCR a different set human medial temporal cortex (MTC) samples (n = 20 vs. controls)....
Patients with liver metastases of triple-negative breast cancer (TNBC) show poor prognosis compared other metastases. Chemotherapy is the primary treatment for advanced TNBC. Tumor cell diversity and tumor microenvironment could affect therapeutic effect. However, whether TNBC exhibit differential chemotherapy efficacy tumors remains inadequately understood. The specific mechanisms that modulate in need further investigation. Single-cell RNA sequencing data from public databases were...
Outcomes associated with use of high-frequency oscillatory ventilation (HFOV) in children acute respiratory failure have not been established.To compare the outcomes HFOV those conventional mechanical (CMV) failure.We performed a retrospective, observational study using deidentified data obtained from all consecutive patients receiving aged 1 month to 18 years Virtual PICU System database January 1, 2009, through December 31, 2011. The population was divided into 2 groups: and CMV. group...
This study demonstrated that a homogeneous polysaccharide (HPS) extracted from Hawthorn exerted anti-cancer effects on colon cancer cells. Human cell line HCT116 were treated with 125–1000 µg/mL HPS for 12 h and subsequent analysis was performed proliferation signaling pathways. significantly inhibited of cells when analyzed using WST-1 assay immunofluorescence staining Ki-67. Flow cytometric studies revealed could arrest the cycle in S G2/M phases increase rate apoptosis. downregulated...
As a crucial part of the symbiotic system, gut microbiome is metabolically connected to many diseases and conditions, including cardiovascular (CVD). Trimethylamine (TMA) produced by bacteria from dietary choline, betaine, or L-carnitine, then converted in liver N-oxide (TMAO), which turn affects hepatic intestinal lipid metabolism. Circulating TMAO positively associated with CVD risk. Because eggs are rich it has been speculated that their consumption may increase plasma TMAO. In this...
Abstract Fucosylation, especially core fucosylation of N‐glycans catalyzed by α1‐6 fucosyltransferase (fucosyltransferase 8 or FUT8), plays an important role in regulating the peripheral immune system and inflammation. However, its microglial activation is poorly understood. Here we used human induced pluripotent stem cells‐derived microglia (hiMG) as a model to study FUT8‐catalyzed amyloid‐β oligomer (AβO)‐induced activation, view significant relevance pathogenesis Alzheimer's disease (AD)....
Immune checkpoint blockade has shown low response rates for advanced breast cancer, and combination strategies are needed. Microwave ablation (MWA) may be a trigger of antitumor immunity. This window-of-opportunity trial (ClinicalTrials.gov: NCT04805736) was conducted to determine the safety feasibility preoperative camrelizumab (an anti-PD-1 antibody) combined with MWA in treatment early-stage cancer.
Metastasis is the major cause of cancer-related death, and lymph node most common site metastasis in breast cancer. However, alterations that happen tumor-draining nodes (TDLNs) to form a premetastatic microenvironment are largely unknown. Here, we first report dynamic changes size immune status TDLNs before With progression tumor, TDLN enlarged immune-activated at early stage contains specific antitumor immunity against metastasis. The then contracted immunosuppressed late finally getting...
Abstract High-density lipoprotein (HDL) particles have multiple beneficial and cardioprotective roles, yet our understanding of their full structural functional repertoire is limited due to challenges in separating HDL from contaminating plasma proteins other lipid-carrying that overlap size and/or density. Here we describe a method for isolating using combination sequential flotation density ultracentrifugation fast protein liquid chromatography with exclusion column. Purity was visualized...
High-density lipoproteins (HDL) play a critical role in cholesterol homeostasis. Apolipoprotein E (APOE), particularly the E4 allele, is significant risk factor for Alzheimer’s disease but also key HDL-associated protein involved lipid transport both periphery and central nervous systems. The objective was to determine influence of APOE genotype on HDL function size context disease. from 194 participants (non-demented controls, mild cognitive impairment, dementia) were isolated plasma....
Abstract Introduction There is an increased need for the development of novel blood‐based biomarkers early detection, prevention, or intervention in Alzheimer's disease (AD). This study sought to determine whether serum glycopeptide analysis holds potential identifying diagnostics and prognostics AD. Methods The involved 195 participants, including 96 patients with AD diagnosis 99 controls no cognitive deficit. Utilizing a validated analytical mass spectrometry method, we monitored...
Autism, a disorder influenced by both genetic and environmental factors, presents significant challenges for prevention treatment. While maternal-infant gut microbiota has been focus in autism research, preventive strategies targeting maternal remain underexplored. This study demonstrates that prenatal probiotic intake can effectively prevent separation-induced autistic-like behaviors offspring without altering the embryonic neurodevelopment mice. Using specific PCR primers cross-fostering...
Abstract Microglia are the immune cells in central nervous system (CNS) and become pro-inflammatory/activated Alzheimer’s disease (AD). Cell surface glycosylation plays an important role cells; however, N-glycosylation glycosphingolipid (GSL) signatures of activated microglia poorly understood. Here, we study comprehensively combined transcriptomic glycomic profiles using human induced pluripotent stem cells-derived (hiMG). Distinct changes patterns amyloid-β oligomer (AβO) LPS-treated hiMG...
Automatic prompt optimization is an important approach to improving the performance of large language models (LLMs). Recent research demonstrates potential using LLMs as optimizers, which can generate improved task prompts via iterative refinement. In this paper, we propose a novel perspective investigate design LLM-based by drawing analogy with gradient-based model optimizers. To connect these two approaches, identify pivotal factors in parameter learning: update direction and method. By...