A5100670777- Child Nutrition and Water Access
- Obesity, Physical Activity, Diet
- Gestational Diabetes Research and Management
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- COVID-19 epidemiological studies
- Nutritional Studies and Diet
- Iron Metabolism and Disorders
- Global Maternal and Child Health
- Food Security and Health in Diverse Populations
- COVID-19 Pandemic Impacts
- COVID-19 and Mental Health
- Vaccine Coverage and Hesitancy
- SARS-CoV-2 and COVID-19 Research
- Global Public Health Policies and Epidemiology
- COVID-19 impact on air quality
- Healthcare Systems and Reforms
- COVID-19 Impact on Reproduction
- Child Nutrition and Feeding Issues
- Cardiovascular Health and Disease Prevention
- Autism Spectrum Disorder Research
- Cancer-related molecular mechanisms research
- Neuroscience and Neuropharmacology Research
- Consumer Attitudes and Food Labeling
- Infant Nutrition and Health
Harvard Global Health Institute
2020-2025
Harvard University
2014-2025
George Mason University
2022-2025
Jiangsu University
2014-2024
Affiliated Hospital of Jiangsu University
2014-2024
McGovern Institute for Brain Research
2012-2024
Massachusetts Institute of Technology
2012-2024
Clinical Trial Investigators
2024
Addis Continental Institute of Public Health
2023
Liaoning Provincial People's Hospital
2021
In this article, we describe a long-non-coding RNA (lncRNA) and disease association database (LncRNADisease), which is publicly accessible at http://cmbi.bjmu.edu.cn/lncrnadisease. recent years, large number of lncRNAs have been identified increasing evidence shows that play critical roles in various biological processes. Therefore, the dysfunctions are associated with wide range diseases. It thus becomes important to understand lncRNAs’ diseases identify candidate for diagnosis, treatment...
Alzheimer's disease (AD) is the most common cause of dementia among older people. There are no effective medications currently available to prevent and treat AD halt progression. Monoacylglycerol lipase (MAGL) primary enzyme metabolizing endocannabinoid 2-arachidonoylglycerol in brain. We show here that inactivation MAGL robustly suppressed production accumulation β-amyloid (Aβ) associated with reduced expression β-site amyloid precursor protein cleaving 1 (BACE1) a mouse model AD....
<h3>Importance</h3> Preclinical and clinical studies have suggested a neuroprotective effect of remote ischemic conditioning (RIC), which involves repeated occlusion/release cycles on bilateral upper limb arteries; however, robust evidence in patients with stroke is lacking. <h3>Objective</h3> To assess the efficacy RIC for acute moderate stroke. <h3>Design, Setting, Participants</h3> This multicenter, open-label, blinded–end point, randomized trial including 1893 was conducted at 55...
<b>Objective</b> To quantify the association between a combination of healthy lifestyle factors before pregnancy (healthy body weight, diet, regular exercise, and not smoking) risk gestational diabetes. <b>Design</b> Prospective cohort study. <b>Setting</b> Nurses' Health Study II, United States. <b>Participants</b> 20 136 singleton live births in 14 437 women without chronic disease. <b>Main outcome measure</b> Self reported incident diabetes diagnosed by physician, validated medical...
The postsynaptic scaffolding protein SH3 and multiple ankyrin repeat domains 3 (SHANK3) is critical for the development function of glutamatergic synapses. Disruption SHANK3-encoding gene has been strongly implicated as a monogenic cause autism, Shank3 mutant mice show repetitive grooming social interaction deficits. Although basal ganglia dysfunction proposed to underlie behaviors, few studies have provided direct evidence support this notion exact cellular mechanisms remain largely...
Abstract Background Obsessive-compulsive disorder (OCD), a severe mental disease manifested in time-consuming repetition of behaviors, affects 1 to 3% the human population. While highly heritable, complex genetics has hampered attempts elucidate OCD etiology. Dogs suffer from naturally occurring compulsive disorders that closely model OCD, as an excessive normal canine behaviors only partially responds drug therapy. The limited diversity within dog breeds makes identifying underlying genetic...
The coronavirus disease 2019 (COVID-19) pandemic may have short-term and long-term impacts on health services across sub-Saharan African countries. A telephone survey in Burkina Faso, Ethiopia, Nigeria was conducted to assess the effects of healthcare from perspectives providers (HCPs) community members. total 900 HCPs (300 each country) 1,797 adult members (approximately 600 participated study. Adjusted risk ratios (ARRs) 95% confidence intervals (CIs) were computed using modified Poisson...
Intellectual disability is a common neurodevelopmental disorder characterized by impaired intellectual and adaptive functioning. Both environmental insults genetic defects contribute to the etiology of disability. Copy number variations SORBS2 have been linked However, neurobiological function in brain unknown. The gene encodes ArgBP2 (Arg/c-Abl kinase binding protein 2) non-neuronal tissues alternatively spliced encode nArgBP2 protein. We found colocalized with F-actin at dendritic spines...
COVID-19 vaccine hesitancy among adolescents poses a challenge to the global effort control pandemic. This multi-country survey aimed assess prevalence and determinants of in sub-Saharan Africa between July December 2021. The was conducted using computer-assisted telephone interviewing five African countries, Burkina Faso, Ethiopia, Ghana, Nigeria, Tanzania. A rural area an urban were included each country (except which only had area), with approximately 300 2662 total. Sociodemographic...
Abstract Autism spectrum disorder (ASD) is characterized by dysfunction in social interactions, stereotypical behaviours and high co-morbidity with intellectual disability. A variety of syndromic non-syndromic neurodevelopmental disorders have been connected to alterations metabotropic glutamate receptor (mGluR) signalling. These receptors contribute synaptic plasticity, spine maturation circuit development. Here, we investigate the physiological role Gprasp2 , a gene linked disabilities...
Coronavirus disease 2019 (COVID-19) can have far-reaching consequences for developing countries through the combined effects of infection and mortality, mitigation measures that impact food systems diets. Using a mobile platform, this cross-sectional study evaluated effect COVID-19 on prices dietary quality 1797 households in Nouna Ouagadougou Burkina Faso, Addis Ababa Kersa Ethiopia, Lagos Ibadan Nigeria. We assessed consumption 20 groups during previous 7 days. The diversity scores (DDS)...
Coronavirus disease 2019 (COVID-19) is a public health emergency affecting the lives of millions people globally. Different measures and extraordinary steps are being taken to contain transmission virus. The levels knowledge implementation preventive practices related COVID-19 in sub-Saharan African countries unclear. Additionally, there lack evidence regarding impacts pandemic on mental health. This study aimed describe assess status among adults three countries: Burkina Faso, Ethiopia,...
We aimed to understand the mortality risks of vulnerable newborns (defined as preterm and/or born weighing smaller or larger compared a standard population), in low- and middle-income countries (LMICs).Descriptive multi-country, secondary analysis individual-level study data babies since 2000.Sixteen subnational, population-based studies from nine LMICs sub-Saharan Africa, Southern Eastern Asia, Latin America.Live birth neonates.We categorically defined five newborn types based on size...
Conventional radiotherapy has a pivotal role in the treatment of glioblastoma; nevertheless, its clinical utility been limited by radiation resistance. There is emerging evidence that upregulated heat shock protein A5 (HSPA5) cancer cells maintains or restores homeostasis cellular microenvironment and results resistance various treatments. Therefore, we describe bioresponsive nanoplatform can deliver HSPA5 inhibitor (pifithrin-μ, PES) radiosensitizer (gold nanosphere, AuNS), to expand...
Introduction Gestational weight gain (GWG) has important implications for maternal and child health is an ideal modifiable factor preconceptional antenatal care. However, the average levels of GWG across all low-income middle-income countries world have not been characterised using nationally representative data. Methods estimates time were computed data from Demographic Health Surveys Program. A hierarchical model was developed to estimate mean total in year 2015 facilitate cross-country...
The coronavirus disease 2019 (COVID-19) pandemic is an unprecedented public health crisis globally. Understanding healthcare providers' (HCPs') knowledge and perceptions of COVID-19 crucial to identifying effective strategies improve their ability respond the in sub-Saharan Africa. A phone-based survey 900 HCPs Burkina Faso, Ethiopia, Nigeria (300 per country) was conducted assess knowledge, perceptions, prevention measures, stigma, mental HCPs. Modified Poisson regression models were used...