Kamran Sadiq
A5103219764- Child Nutrition and Water Access
- Child Nutrition and Feeding Issues
- Viral gastroenteritis research and epidemiology
- Global Maternal and Child Health
- Infant Nutrition and Health
- Colorectal Cancer Screening and Detection
- Healthcare Systems and Reforms
- Food Security and Health in Diverse Populations
- Helicobacter pylori-related gastroenterology studies
- Clinical Nutrition and Gastroenterology
- Digestive system and related health
- Microscopic Colitis
- Nutrition and Health in Aging
- Neonatal Respiratory Health Research
- Autopsy Techniques and Outcomes
- Inflammatory Bowel Disease
- Congenital gastrointestinal and neural anomalies
- Vaccine Coverage and Hesitancy
- Gastroesophageal reflux and treatments
- Celiac Disease Research and Management
- Body Composition Measurement Techniques
- Poverty, Education, and Child Welfare
- Birth, Development, and Health
- AI in cancer detection
- Escherichia coli research studies
Aga Khan University
2015-2024
Aga Khan University Hospital
2017-2024
British Columbia Children's Hospital
2018-2023
University of Venda
2023
Sustainable Development Goal 2.2-to end malnutrition by 2030-includes the elimination of child wasting, defined as a weight-for-length z-score that is more than two standard deviations below median World Health Organization standards for growth
Globally, 149 million children under 5 years of age are estimated to be stunted (length more than 2 standard deviations below international growth standards)
Abstract Growth faltering in children (low length for age or low weight length) during the first 1,000 days of life (from conception to 2 years age) influences short-term and long-term health survival 1,2 . Interventions such as nutritional supplementation pregnancy postnatal period could help prevent growth faltering, but programmatic action has been insufficient eliminate high burden stunting wasting low- middle-income countries. Identification windows population subgroups on which focus...
Globally, clinical certification of the cause neonatal death is not commonly available in developing countries. Under such circumstances it imperative to use WHO verbal autopsy tool ascertain causes for strategic health planning countries where resources are limited and burden high. The study explores diagnostic accuracy revised ascertaining deaths against reference standard diagnosis obtained from standardized supportive hospital data.All were recruited between August 2006 -February 2008...
Background & AimsEnvironmental enteric dysfunction (EED) limits the Sustainable Development Goals of improved childhood growth and survival. We applied mucosal genomics to advance our understanding EED.MethodsThe Study Environmental Enteropathy Malnutrition (SEEM) followed 416 children from birth 24 months in a rural district Pakistan. Biomarkers were measured at 9 tested for association with months. The duodenal methylome transcriptome determined 52 undernourished SEEM participants 42 North...
Abstract Background More than 450 newborns die every hour worldwide, before they reach the age of four weeks (neonatal period) and over 500,000 women from complications related to childbirth. The major direct causes neonatal death are infections (36%), Prematurity (28%) Asphyxia (23%). Pakistan has one highest perinatal mortality rates in region contributes significantly global mortality. high partially attributable scarcity trained skilled birth attendants paucity resources. Empowerment...
Background A major limitation to understanding the etiopathogenesis of environmental enteric dysfunction (EED) is lack a comprehensive, reproducible histologic framework for characterizing small bowel lesions. We hypothesized that development such system will identify unique histology features EED, and some might correlate with clinical severity. Methods Duodenal endoscopic biopsies from two cohorts where EED prevalent (Pakistan, Zambia) North American children without gluten sensitive...
Abstract Environmental Enteric Dysfunction (EED), a syndrome characterized by chronic gut inflammation, contributes towards stunting and poor response to enteric vaccines in children developing countries. In this study, we evaluated major putative biomarkers of EED using growth faltering as its clinical proxy. Newborns (n = 380) were enrolled followed till 18 months with monthly anthropometry. Biomarkers associated systemic inflammation assessed at 6 9 months. Linear mixed effects model was...
Objective To determine the prevalence and possible factors associated with anaemia, vitamin B 12 folate deficiencies in women of reproductive age (WRA) Pakistan. Methods A secondary analysis was conducted on data collected through large-scale National Nutrition Survey Pakistan 2011. Anaemia defined as haemoglobin levels <12 g/dL, deficiency serum <203 pg/mL (150 pmol/L) <4 ng/mL (10 nmol/L). Results total 11 751 blood samples were analysed. The 50.4%, 52.4% 50.8%, respectively....
Duodenal biopsies from children with enteropathies associated undernutrition, such as environmental enteropathy (EE) and celiac disease (CD), display significant histopathological overlap.To develop a convolutional neural network (CNN) to enhance the detection of pathologic morphological features in diseased vs healthy duodenal tissue.In this prospective diagnostic study, CNN consisting 4 convolutions, 1 fully connected layer, softmax layer was trained on biopsy images. Data were provided by...
Environmental Enteropathy (EE), characterized by alterations in intestinal structure, function, and immune activation, is believed to be an important contributor childhood undernutrition its associated morbidities, including stunting. Half of all global deaths children < 5 years are attributable under-nutrition, making the study EE area critical priority. Community based intervention study, divided into two sub-studies, 1) Longitudinal analyses 2) Biopsy studies for identification features...
Introduction Environmental enteropathy is an important contributor to childhood malnutrition in the developing world. Chronic exposure fecal pathogens leads alteration intestinal structure and function, resulting impaired gut immune malabsorption, growth faltering leading environmental enteropathy. Methods A community-based intervention study was carried out on children till 24 months of age Matiari district, Pakistan. Blood specimens were collected from enrolled aged 3–6 9 months. real-time...
Environmental enteric dysfunction (EED), a chronic inflammatory condition of the small intestine, is an important driver childhood malnutrition globally. Quantifying intestinal morphology in EED allows for exploration its association with functional and disease outcomes.
Environmental enteric dysfunction (EED) is a subclinical syndrome of altered small intestinal function postulated to be an important contributor childhood undernutrition. The role bacterial communities in the pathophysiology EED poorly defined due paucity studies where there has been direct collection samples from undernourished children. Sixty-three members Pakistani cohort identified as being acutely malnourished between 3 and 6 months age whose wasting (weight-for-length
Despite nutrition interventions, stunting thought to be secondary underlying environmental enteropathy (EE) remains pervasive among infants residing in resource-poor countries and poorly characterized. From a birth cohort of 380 children, 65 malnourished received 12 weeks nutritional supplementation with ready-to-use therapeutic food (RUTF). Eleven children insufficient response RUTF underwent upper endoscopy duodenal biopsies, which were compared U.S., age-matched specimens for healthy,...
Intestinal inflammation and malabsorption in environmental enteric dysfunction (EED) are associated with early childhood growth faltering impoverished settings worldwide. The goal of this study was to identify candidate biomarkers inflammation, EED histology, as predictors later outcomes by focusing on the liver-gut axis investigating bile acid metabolome. Undernourished rural Pakistani infants (n = 365) weight-for-height Z score (WHZ) < -2 were followed up age 24 mo monitored for growth,...
Abstract Background Plummer–Vinson syndrome (PVS) is characterized by a triad of symptoms consisting microcytic hypochromic anaemia, oesophageal webs, and dysphagia. PVS commonly found in women the fourth fifth decades life rarely reported paediatric population. Case presentation We report case 1-year-old male South Asian child who presented with dysphagia anaemia for 4 months frequent episodes vomiting after ingesting semisolid solid food. A complete blood analysis revealed anaemia. An...