A5030838551- Congenital Heart Disease Studies
- Mesenchymal stem cell research
- Cardiac Ischemia and Reperfusion
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Aortic Disease and Treatment Approaches
- Pulmonary Hypertension Research and Treatments
- Tissue Engineering and Regenerative Medicine
- Tracheal and airway disorders
- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Infective Endocarditis Diagnosis and Management
- Coronary Artery Anomalies
- Anesthesia and Neurotoxicity Research
- Cardiac Fibrosis and Remodeling
- Congenital heart defects research
- Cytokine Signaling Pathways and Interactions
- Transplantation: Methods and Outcomes
- Electrospun Nanofibers in Biomedical Applications
- Immune Response and Inflammation
- Cardiac, Anesthesia and Surgical Outcomes
- Estrogen and related hormone effects
- Vascular anomalies and interventions
- Clinical Nutrition and Gastroenterology
- Cardiac Arrhythmias and Treatments
Indiana University – Purdue University Indianapolis
2011-2025
Children's Hospital of Philadelphia
2014-2025
Indiana University Health
2018-2025
Riley Hospital for Children
2018-2025
Indiana University School of Medicine
2010-2024
Houston Methodist
2023
Creative Commons
2022
Indiana University
2007-2022
University School
2022
Eastern Virginia Medical School
2022
Mesenchymal stem cells (MSCs) are a promising therapy for acute organ ischemia in part due to their paracrine production of growth factors. However, transplanted encounter an inflammatory environment that mitigates function and survival, treating the with exogenous agents during ex vivo expansion before transplantation is one strategy overcoming this limitation by enhancing function. We hypothesized preconditioning bone marrow MSCs TGF-alpha would 1) increase MSC critical factor, vascular...
Bone marrow mesenchymal stem cells (MSCs) may be a novel treatment modality for organ ischemia, possibly through the release of beneficial paracrine factors. However, an age threshold likely exists as to when MSCs gain their protective properties. We hypothesized that 1) VEGF would crucial cell mediator in providing postischemic myocardial protection and 2) small-interfering (si)RNA ablation adult (aMSCs) equalize differences observed between aMSC- neonatal (nMSC)-mediated cardioprotection....
Females have a lower incidence of heart failure and improved survival after myocardial ischemia-reperfusion (I/R) compared with males. Although estrogen-suppressed cardiomyocyte apoptosis may be mediated through the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway, it is unclear whether this action via estrogen receptor beta (ERbeta). Therefore, we hypothesized that ERbeta mediates estrogen-induced cardioprotection PI3K/Akt antiapoptotic signaling in females but not...
Optimizing the function and proliferative capacity of stem cells is essential to maximize their therapeutic benefits. High glucose concentrations are known have detrimental effects on many cell types. We hypothesized that human mesenchymal (hMSCs) cultured in high glucose-containing media would exhibit diminished proliferation attenuated production VEGF, hepatocyte growth factor (HGF), FGF2 response treatment with TNF-alpha, LPS, or hypoxia. hMSCs were plated medium containing low (5.5 mM)...
Mesenchymal stem cells (MSCs) possess immunomodulatory properties and may curtail the inflammatory response that characterizes sepsis other systemic states. We aimed to determine whether intravenous infusion of MSCs is associated with reduced inflammation improved myocardial function in a rat model endotoxemia. Adult Sprague-Dawley rats were administered saline (vehicle) or LPS (5 mg/kg) via tail vein injection. Treatments, either vehicle 2 × 10(6) MSCs, infused 1 h later vein. Animals...
Optimal right ventricle-to-pulmonary artery (RV-PA) conduit size for patients with truncus arteriosus is controversial. We aimed to determine the relationship between branch PA and need reoperation following repair of arteriosus. performed a single-center chart review who underwent from January 2009 December 2023. Branch PAs were measured in systole, at narrowest point if focal stenosis was present. For diameter analyses, smaller used. Univariate Cox proportional hazards regression analysis...
Abstract We report on 11 cases of amyoplasia in one identical twins. In total, 135 patients with were ascertained from a study 350 multiple congenital joint contractures (arthrogryposis). These twins represent 8% our amyoplasia. At least 18 sets have been reported previously. However, only four these appear to involve discordant for Thus, 15 which are affected identified.
Mesenchymal stem cells (MSCs) may improve myocardial function after I/R injury via paracrine effects, including the release of growth factors. Genetic modification MSCs is an appealing method to enhance MSC action. Ablation TNF receptor 1 (TNFR1), but not TNFR2, increases factor production. In this study, therefore, we hypothesized that 1) preischemic infusion derived from TNFR1 knockout (TNFR1KO) mice will further functional recovery and 2) TNFR2KO TNFR1/2KO abolish MSC-mediated protection...
Background Bone marrow-derived mesenchymal stem cells (MSC) improve myocardial recovery after ischemia/reperfusion (I/R) injury. These effects are mediated in part by the paracrine secretion of angiogenic and tissue growth-promoting factors. Toll-like receptor 4 (TLR4) is expressed MSC induces apoptosis inhibits proliferation neuronal progenitors as well many other cell types. It unknown whether knock-out (KO) TLR4 will change properties turn MSC-associated protection. Methodology/Principal...
Toll-like receptor 2 (TLR2), a key component of the innate immune system, is linked to inflammation and myocardial dysfunction after ischemia-reperfusion injury (I/R). Treatment heart with mesenchymal stem cells (MSCs) known improve recovery I/R in part by paracrine factors such as VEGF. However, it unknown whether TLR2 activation on MSCs affects MSC-mediated VEGF production. We hypothesized that knockout (TLR2KO MSCs) would 1) 2) increase MSC release. With isolated perfusion Sprague-Dawley...