A5030549451- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Respiratory Support and Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Trauma and Emergency Care Studies
- Sepsis Diagnosis and Treatment
- Non-Invasive Vital Sign Monitoring
- Disaster Response and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Trauma Management and Diagnosis
- Heart Rate Variability and Autonomic Control
- Airway Management and Intubation Techniques
- Anesthesia and Neurotoxicity Research
- Congenital Heart Disease Studies
- Traumatic Brain Injury Research
- Emergency and Acute Care Studies
- Intensive Care Unit Cognitive Disorders
- Thermal Regulation in Medicine
- Hemodynamic Monitoring and Therapy
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Syncope and Autonomic Disorders
- Optical Imaging and Spectroscopy Techniques
- Advanced Optical Network Technologies
- Family and Patient Care in Intensive Care Units
- Cardiac Ischemia and Reperfusion
Children's Hospital of Philadelphia
2016-2025
University of Pennsylvania
2015-2025
Philadelphia University
2015-2025
Public Health Department
2024
Texas Tech University
2024
Texas Tech University Health Sciences Center
2024
University of South Florida
2023-2024
Microsoft (United States)
2021-2023
University of Chicago
2023
University of California, Irvine
2023
xisting American Heart Association cardiopulmonary resuscitation (CPR) guidelines do not address the challenges of providing in setting coronavirus disease 2019 (COVID-19) global pandemic, wherein rescuers must continuously balance immediate needs patients with their own safety.To this gap, Association, collaboration Academy Pediatrics, for Respiratory Care, College Emergency Physicians, The Society Critical Care Anesthesiologists, and support Nurses National EMS has compiled interim...
ABSTRACT Multiple environmental cues have been shown to trigger biofilm detachment, the transition from surface-attached, highly organized communities known as biofilms motile lifestyle. The goal of this study was identify a gene product involved in sensing that dispersion Pseudomonas aeruginosa . To do so, we focused on novel putative chemotaxis transducer proteins could potentially be sensing. We identified locus encoding such protein played role indicated by observation an isogenic mutant...
Approximately 40% of children who experience an in-hospital cardiac arrest survive to hospital discharge. Achieving threshold intra-arrest diastolic blood pressure (BP) targets during cardiopulmonary resuscitation (CPR) and systolic BP after the return circulation may be associated with improved outcomes.To evaluate effectiveness a bundled intervention comprising physiologically focused CPR training at point care structured clinical event debriefings.A parallel, hybrid stepped-wedge, cluster...
Less than half of the thousands children who suffer in-hospital cardiac arrests annually survive, and neurologic injury is common among survivors. Hemodynamic-directed cardiopulmonary resuscitation improves short-term survival, but its impact on longer term survival mitochondrial respiration-a potential neurotherapeutic target-remains unknown. The primary objectives this study were to compare rates 24-hour with favorable outcome after arrest treated hemodynamic-directed versus standard...
Physiology-guided cardiopulmonary resuscitation (CPR) offers the potential to optimize and enable early prognosis. Physiology-Guided CPR was one of six focus topic for Wolf Creek XVII Conference held on June 14–17, 2023 in Ann Arbor, Michigan, USA. International thought leaders scientists field cardiac arrest from academia industry were invited. Participants submitted via online survey knowledge gaps, barriers translation research priorities each topic. Expert panels used results their own...
The association between chest compression (CC) pause duration and pediatric in-hospital cardiac arrest survival outcomes is unknown. American Heart Association has recommended minimizing pauses in CC children to <10 seconds, without supportive evidence. We hypothesized that longer maximum durations are associated with worse neurological outcomes.
Although advances in cardiopulmonary resuscitation have improved survival from cardiac arrest (CA), neurologic injury persists and impaired mitochondrial bioenergetics may be critical for targeted neuroresuscitation. The authors sought to determine if excellent postresuscitation care good traditional rates result persistently disordered cerebral a porcine pediatric model of asphyxia-associated ventricular fibrillation CA.After 7 minutes asphyxia, followed by fibrillation, 5 female...
The objective of this study was to associate ventilation rates during in-hospital cardiopulmonary resuscitation with 1) arterial blood pressure and 2) survival outcomes.Prospective, multicenter observational study.Pediatric pediatric cardiac ICUs the Collaborative Pediatric Critical Care Research Network.Intubated children (≥ 37 wk gestation < 19 yr old) who received at least 1 minute resuscitation.None.Arterial rate (breaths/min) were manually extracted from line capnogram waveforms....
Abstract Background Despite controversies, epinephrine remains a mainstay of cardiopulmonary resuscitation (CPR). Recent animal studies have suggested that may decrease cerebral blood flow (CBF) and oxygenation, possibly potentiating neurological injury during CPR. We investigated the cerebrovascular effects intravenous in swine model pediatric in-hospital cardiac arrest. The primary objectives this study were to determine if (1) doses significant acute effect on CBF tissue oxygenation CPR...
OBJECTIVES: Arterial diastolic blood pressure (DBP) greater than 25 mm Hg in infants and 30 children 1 year old during cardiopulmonary resuscitation (CPR) was associated with survival to hospital discharge one prospective study. We sought validate these potential hemodynamic targets a larger multicenter cohort. DESIGN: Prospective observational SETTING: Eighteen PICUs the ICU-RESUScitation trial from October 2016 March 2020. PATIENTS: Children less or equal 18 years CPR seconds invasive (BP)...
Abstract Background Epinephrine is provided during cardiopulmonary resuscitation (CPR) to increase systemic vascular resistance and generate higher diastolic blood pressure (DBP) improve coronary perfusion attain return of spontaneous circulation (ROSC). The DBP response epinephrine pediatric CPR its association with outcomes have not been well described. Thus, the objective this study was measure between change in after administration ROSC. Methods This a prospective multicenter children...
OBJECTIVE: Quantify hypotension burden using high-resolution continuous arterial blood pressure (ABP) data and determine its association with outcome after pediatric cardiac arrest. DESIGN: Retrospective observational study. SETTING: Academic PICU. PATIENTS: Children 18 years old or younger admitted in-of-hospital out-of-hospital arrest who had invasive ABP monitoring during postcardiac care. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: High-resolution was analyzed up to 24 hours the...
To evaluate associations between sodium bicarbonate use and outcomes during pediatric in-hospital cardiac arrest (p-IHCA).Prespecified secondary analysis of a prospective, multicenter cluster randomized interventional trial.Eighteen participating ICUs the ICU-RESUScitation Project (NCT02837497).Children less than or equal to 18 years old greater 37 weeks post conceptual age who received chest compressions any duration from October 2016 March 2021.None.Child event characteristics, prearrest...
To characterize chest compression (CC) pause duration during the last 5 minutes of pediatric cardiopulmonary resuscitation (CPR) prior to extracorporeal-CPR (E-CPR) cannulation and association with survival outcomes.Cohort study from a quality collaborative including E-CPR cardiac arrest events ≥ 10 min CPR data. We characterized CC interruptions defibrillator-electrode recorded (prior cannulation) assessed between longest outcomes using multivariable logistic regression.Of 49 events, median...