Melissa Chan

ORCID: 0000-0003-3605-4644
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About
Contact & Profiles
Research Areas
  • Cardiac Arrest and Resuscitation
  • Mechanical Circulatory Support Devices
  • Respiratory Support and Mechanisms
  • Family and Patient Care in Intensive Care Units
  • Construction Project Management and Performance
  • Outsourcing and Supply Chain Management
  • Child and Adolescent Health
  • Trauma Management and Diagnosis
  • Innovations in Medical Education
  • Infant Development and Preterm Care
  • Disaster Response and Management
  • Public Procurement and Policy
  • Trauma and Emergency Care Studies
  • Simulation-Based Education in Healthcare
  • Diversity and Career in Medicine
  • Agriculture and Rural Development Research
  • Emergency and Acute Care Studies
  • Pediatric Pain Management Techniques
  • COVID-19 and healthcare impacts
  • Medical and Health Sciences Research
  • Primary Care and Health Outcomes
  • Inflammatory Bowel Disease
  • Hospital Admissions and Outcomes
  • Patient Safety and Medication Errors
  • Medical Education and Admissions

Incyte (United States)
2025

University of Calgary
2022-2024

University of British Columbia
2013-2022

Stollery Children's Hospital
2017-2022

University of Alberta Hospital
2022

British Columbia Children's Hospital
2013-2022

University of Alberta
2016-2021

George Washington University
2020

The University of Texas at Austin
2020

University of Pennsylvania
2020

xisting American Heart Association cardiopulmonary resuscitation (CPR) guidelines do not address the challenges of providing in setting coronavirus disease 2019 (COVID-19) global pandemic, wherein rescuers must continuously balance immediate needs patients with their own safety.To this gap, Association, collaboration Academy Pediatrics, for Respiratory Care, College Emergency Physicians, The Society Critical Care Anesthesiologists, and support Nurses National EMS has compiled interim...

10.1161/circulationaha.120.047463 article EN mit Circulation 2020-04-09

This 2018 American Heart Association focused update on pediatric advanced life support guidelines for cardiopulmonary resuscitation and emergency cardiovascular care follows the evidence review performed by Pediatric Task Force of International Liaison Committee Resuscitation. It aligns with Resuscitation’s continuous process, updates are published when group completes a literature based new evidence. provides treatment recommendation antiarrhythmic drug therapy in shock-refractory...

10.1161/cir.0000000000000612 article EN Circulation 2018-12-03

General emergency department crowding negatively impacts patient care, and increases morbidity. This study seeks to determine if markers of paediatric (PED) flow are independently associated with negative outcomes increased health care utilization. We conducted a retrospective cohort PED visits from 2008 2012. Data were pulled an electronic administrative database. Using multivariate logistic regression models, we measured the association between odds adverse (hospital/paediatric intensive...

10.1093/pch/pxx111 article EN Paediatrics & Child Health 2017-09-25

Abstract Host immune responses play an important role in fighting cancers; therefore, improving these against tumor cells is of high interest cancer therapy. Diacylglycerol (DAG) a key second messenger that transduces T-cell receptor (TCR) activation signal to downstream effectors through DAG-binding proteins. DAG kinase (DGK) isoforms α and ζ are the major enzymes modulate levels T serve as intracellular checkpoints attenuate TCR activation. Here, we describe INCB177054, novel, potent,...

10.1158/1538-7445.am2025-3789 article EN Cancer Research 2025-04-21

Physician trainees in neonatology can find it extremely challenging to care for patients from diverse linguistic and multicultural backgrounds. This challenge is particularly highlighted when difficult ethically end-of-life (EOL) decision-making with parents required. While these interactions are an opportunity growth learning, they also have the potential lead misunderstanding uncertainty add trainees' insecurity, unpreparedness stress participating such interactions.To explore challenges...

10.1136/archdischild-2012-303000 article EN Archives of Disease in Childhood Fetal & Neonatal 2013-07-30

The author examined the intergroup conflict between R&D managers and non-managers in four aerospace companies, as well relationship each of five conflict-handling modes: competition, accommodation, sharing, collaboration, avoidance, with following variables: frequency, job satisfaction, performance. research findings indicate that conflicts were areas goals, reward, control, authority, insufficient assistance from technical support staff. Furthermore, management found to have both positive...

10.1109/17.18823 article EN IEEE Transactions on Engineering Management 1989-05-01

In 2013, the TRAPPED-1 survey reported inconsistent availability of pain and distress management strategies across all 15 Canadian paediatric emergency department (PEDs). The objective TRAPPED-2 study was to utilize a procedural quality improvement collaborative (QIC) evaluate number newly introduced distress-reducing in PEDs over 2-year period. A QIC created increase implementation new strategies, through information sharing among PEDs. 2015, 11 participated TRAPPED QIC. At end year,...

10.1093/pch/pxx186 article EN Paediatrics & Child Health 2018-02-05

Assessment and stabilization of the newborn are expected competencies trainees graduating from Canadian paediatrics residency training programs. There is limited evidence regarding optimal approach to training, whether such actually achieved by graduates. A national, cross-sectional survey was developed explore residents' self-reported experiences in performing neonatal procedures resuscitation skills. Survey questions were constructed based on review Royal College Physicians Surgeons Canada...

10.1093/pch/pxy061 article EN Paediatrics & Child Health 2018-05-29

A common complication of type 1 diabetes mellitus is diabetic ketoacidosis (DKA), a state severe insulin deficiency. potentially harmful consequence DKA therapy in children cerebral edema (DKA-CE); however, the mechanisms therapy-induced DKA-CE are unknown. Our aims were to identify treatment factors and membrane that might contribute specifically brain cell swelling. To this end, was induced juvenile mice with administration pancreatic toxins streptozocin alloxan. Brain slices prepared...

10.1152/ajpendo.00107.2015 article EN AJP Endocrinology and Metabolism 2015-06-17

Despite the high number of children treated in emergency departments, patient safety risks this setting are not well quantified. Our objective was to estimate risk and type adverse events, as their preventability severity, for a paediatric department. prospective, multicentre cohort study enrolled presenting care during one 168 8-hour shifts across nine departments. primary outcome an event within 21 days enrolment which related provided at visit. We identified 'flagged outcomes' (such...

10.1136/bmjqs-2021-014608 article EN cc-by-nc BMJ Quality & Safety 2022-07-19

Background: Southwestern Ontario largely comprises rural farming districts and is home to numerous Old-Order Anabaptist settlements. Our objective was describe the injuries sustained by children, both non-Anabaptist, better target injury prevention programs. Methods: We retrospectively examined data of children in with severity scores ≥12 obtained from hospital trauma databases (1997–2007). Results: A total 422 were included this study: 7.8% (n = 33) 92.2% non-Anabaptist 389). The age...

10.1097/ta.0b013e3181fa7e25 article EN Journal of Trauma and Acute Care Surgery 2010-11-01
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