A5019010792- Mesenchymal stem cell research
- Pulmonary Hypertension Research and Treatments
- Neonatal Respiratory Health Research
- Neurotransmitter Receptor Influence on Behavior
- Spaceflight effects on biology
- Tissue Engineering and Regenerative Medicine
- Angiogenesis and VEGF in Cancer
- Space Exploration and Technology
- Cardiac Ischemia and Reperfusion
- Cancer Cells and Metastasis
- Parkinson's Disease Mechanisms and Treatments
- Osteoarthritis Treatment and Mechanisms
- Substance Abuse Treatment and Outcomes
- Indoor Air Quality and Microbial Exposure
- Wound Healing and Treatments
- Congenital Heart Disease Studies
- Infant Nutrition and Health
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer, Hypoxia, and Metabolism
- Decision-Making and Behavioral Economics
- Hormonal and reproductive studies
- Digestive system and related health
- Multisensory perception and integration
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Advanced Fluorescence Microscopy Techniques
Indiana University Bloomington
2017
East Carolina University
2017
Vidant Medical Center
2017
Campbell University
2017
Texas A&M University
2017
Indiana University – Purdue University Indianapolis
2006-2016
Indiana University School of Medicine
2006-2016
Indiana University
2006-2015
University School
2012
University Medical Center
2006
Accumulating evidence suggests that progenitor cells may decrease destructive inflammation and reduce tissue loss by antiapoptotic mechanisms. However, they remain poorly characterized, many questions regarding the mechanisms which positively affect wound healing, remodeling, or regeneration. It has been speculated various growth factors are responsible, but what components of milieu stimulate cell production mechanisms? We hypothesized tumor necrosis factor-alpha (TNF-alpha) stimulated...
Bone marrow mesenchymal stem cells (MSCs) may be a novel treatment modality for organ ischemia, possibly through the release of beneficial paracrine factors. However, an age threshold likely exists as to when MSCs gain their protective properties. We hypothesized that 1) VEGF would crucial cell mediator in providing postischemic myocardial protection and 2) small-interfering (si)RNA ablation adult (aMSCs) equalize differences observed between aMSC- neonatal (nMSC)-mediated cardioprotection....
Objectives The objectives of this study were to determine efficacy hearing aids in older adults using audiology best practices, evaluate the an alternative over-the-counter (OTC) intervention, and examine influence purchase price on outcomes for both service-delivery models. Design design was a single-site, prospective, double-blind placebo-controlled randomized trial with three parallel branches: (a) practices (AB), (b) consumer decides OTC model (CD), (c) placebo devices (P). Outcome...
Sex differences exist in a variety of cardiovascular disorders. hormones have been shown to mediate pulmonary artery (PA) vasodilation. However, the effects fluctuations physiological sex hormone levels due and menstrual cycle on PA vasoreactivity not clearly established yet. We hypothesized that affect vasoconstriction under both normoxic hypoxic conditions. Isometric force displacement was measured isolated rings from proestrus females (PF), estrus diestrus (E/DF), male (M) Sprague-Dawley...
The plasticity of bone marrow-derived stem cells (BMSCs) has resulted in positive remodeling and the regeneration viable tissues. However, BMSC release growth factors, which limit apoptosis inflammation, may play an important role conferring organ protection. Recent studies also indicate that those patients with higher circulating counts be more resistant to septic traumatic insults. There are clear sex differences response such Within population BMSC, mesenchymal (MSCs) have clinical...
Selected surfaces from the Command Module, Lunar Module (ascent and descent stages), Instrument Unit, Saturn S-4B engine, Spacecraft Adapter comprised various components of four Apollo spacecraft which were assayed quantitatively qualitatively for microorganisms. In addition, first Roving Vehicle was assayed. Average levels microbial contamination (10 4 per square foot surface) on engine relatively consistent among spacecraft. The postflight sampling interior possible due to elimination...
Necrotizing enterocolitis (NEC) is an emergency of the newborn that often requires surgery. Growth factors from stem cells may aid in decreasing intestinal damage while also promoting restitution. We hypothesized 1) TNF, LPS, or hypoxia would alter bone marrow mesenchymal cell (BMSC) IGF-1, IL-6, and VEGF production, 2) TNF receptor type 1 (TNFR1) 2 (TNFR2) ablation result changes to patterns cytokines growth produced. BMSCs were harvested female wild-type (WT), TNFR1 knockout (KO), TNFR2KO...
Tumor necrosis factor-alpha (TNF-alpha) plays an important role in the development of heart failure. There is a direct correlation between myocardial function and TNF levels humans. may induce local inflammation to exert tissue injury. On other hand, suppressors cytokine signaling (SOCS) proteins have been shown inhibit proinflammatory signaling. However, it unknown whether mediates via STAT3/SOCS3 and, if so, this effect through type 1 55-kDa receptor (TNFR1). We hypothesized that TNFR1...
Bacteria have developed mechanisms to sequester host iron via chelators such as deferoxamine (DFO). Interestingly, DFO has been shown stimulate acute intestinal epithelial cell inflammatory cytokine production in the absence of bacteria; however, this mechanism not elucidated. Intestinal IL-6 and TNF-alpha is elevated various gastrointestinal pathologies, including ischemia. Similarly, VEGF HGF are essential integrity. Therapeutic strategies that decrease while increasing therefore...
Abstract Knowledge of the reproducibility striatal [ 11 C]raclopride (RAC) binding is important for studies that use RAC PET paradigms to estimate changes in dopamine (DA) during pharmacological and cognitive challenges. To our knowledge, no baseline test–retest data exist nontreatment‐seeking alcoholics (NTS). We determined potential (BP ND ) 12 male NTS subjects. Subjects were scanned twice with single‐bolus on separate days. Striatal BP left right dorsal caudate, putamen, ventral striatum...
Due to area constraints encountered in assembly and testing areas of spacecraft, the membrane filter field monitor (MF) National Aeronautics Space Administration-accepted Reyniers slit air sampler were compared for recovery airborne microbial contamination. The intramural a microbiological laboratory clean room environment used Apollo spacecraft was studied. A significantly higher number microorganisms recovered by sampler. high degree consistency between two sampling methods shown...
Modulating the paracrine effects of bone marrow mesenchymal stem cells (BMSCs) may be important for treatment ischemic myocardial tissue. In this regard, endogenous estrogen enhance BMSC vascular endothelial growth factor (VEGF) production. However, little information exists regarding effect testosterone on cell function. We hypothesized that 1) or exogenous will production VEGF and 2) inhibit BMSCs were collected from adult male, female, castrated ovariectomized female rats. One hundred...
The ability to determine the thermal resistance of naturally occurring air borne bacterial spores associated with spacecraft and their assembly areas has been hindered by lack an effective collecting system. Efforts collect concentrate samplers or from filters have not successful. A fallout method was developed for this purpose tested. Sterile Teflon ribbons (7.6 183 cm) were exposed in pertinent subsequently treated dry heat. Thermal inactivation experiments conducted at 125 113 C. Heating...
The ability to determine the thermal resistance of naturally occurring air borne bacterial spores associated with spacecraft and their assembly areas has been hindered by lack an effective collecting system. Efforts collect concentrate samplers or from filters have not successful. A fallout method was developed for this purpose tested. Sterile Teflon ribbons (7.6 183 cm) were exposed in pertinent subsequently treated dry heat. Thermal inactivation experiments conducted at 125 113 C. Heating...
Five media, including Trypticase soy agar (TSA; BBL) pour plates, spread plates of TSA, Mycophil with chloromycetin, chloromycetin and Actidione, cornmeal were quantitatively qualitatively compared for the detection fungi on spacecraft. Cornmeal yielded highest number fungal colonies, although not always significantly higher than or TSA plates. also gave best qualitative representation spacecraft, recovering 68% genera found from all media. This medium 10 times colonies 3 as currently used...