A5062219712- Birth, Development, and Health
- Child Nutrition and Water Access
- Obesity, Physical Activity, Diet
- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Folate and B Vitamins Research
- Diet and metabolism studies
- Nutritional Studies and Diet
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Bone health and osteoporosis research
- Epigenetics and DNA Methylation
- Global Public Health Policies and Epidemiology
- Diabetes and associated disorders
- Food Security and Health in Diverse Populations
- Diet, Metabolism, and Disease
- Growth Hormone and Insulin-like Growth Factors
- Global Maternal and Child Health
- Health disparities and outcomes
- Cardiovascular Health and Risk Factors
- Genetic Associations and Epidemiology
- Vitamin D Research Studies
- Infant Nutrition and Health
- Nutrition and Health in Aging
- Iron Metabolism and Disorders
- Diabetes Management and Research
MRC Lifecourse Epidemiology Unit
2016-2025
University of Southampton
2016-2025
Southampton General Hospital
2015-2024
Medical Research Council
2014-2023
Southampton City Council
1998-2021
University of Aberdeen
2018
University Hospital Southampton NHS Foundation Trust
2018
Social Change and Development
2009-2017
CSI Holdsworth Memorial Hospital
2013-2014
Southmead Hospital
2014
OBJECTIVE--To discover whether reduced fetal and infant growth is associated with non-insulin dependent diabetes impaired glucose tolerance in adult life. DESIGN--Follow up study of men born during 1920-30 whose birth weights at 1 year were known. SETTING--Hertfordshire, England. SUBJECTS--468 east Hertfordshire still living there. MAIN OUTCOME MEASURES--Fasting plasma glucose, insulin, proinsulin, 32-33 split pro-insulin concentrations insulin 30 120 minutes after a 75 g drink. RESULTS--93...
The risk of type 2 diabetes mellitus is increased in people who have low birth weights and subsequently become obese as adults. Whether their obesity originates childhood and, if so, at what age are unknown. Understanding the origin may be especially important developing countries, where rapidly increasing yet public health messages still focus on reducing "undernutrition."We evaluated glucose tolerance plasma insulin concentrations 1492 men women 26 to 32 years had been measured intervals...
OBJECTIVE--To examine whether birth weight, infant and childhood respiratory infection are associated with adult lung function death from chronic obstructive airways disease. DESIGN--Follow up study of men born during 1911-30 whose weights, weights at 1 year, illnesses were recorded the time by health visitors. SETTING--Hertfordshire, England. SUBJECTS--5718 in county a subgroup 825 1920-30 still living there. MAIN OUTCOME MEASURES--Death disease, mean forced expiratory volume one second...
To determine whether the link suggested between growth in utero and during infancy death from cardiovascular disease men is also present women.Follow up study of women whose birth weight at 1 year age had been recorded.Hertfordshire, England.5585 10,141 born 1911-30.Standardised mortality ratios for disease.Among rates fell progressively low high weights groups (chi 2 = 4.3, p 0.04 women, chi 8.5, < 0.005 men). Cardiovascular deaths but not were strongly related to year, falling 27.5,...
Raised maternal plasma total homocysteine (tHcy) concentrations predict small size at birth, which is a risk factor for type 2 diabetes mellitus. We studied the association between vitamin B12, folate and tHcy status during pregnancy, offspring adiposity insulin resistance 6 years. In Pune Maternal Nutrition Study we 700 consecutive eligible pregnant women in six villages. measured nutritional intake circulating of folate, methylmalonic acid (MMA) 18 28 weeks gestation. These were correlated...
We have studied 477 8-year-old Indian children to define the relationship between birth weight and cardiovascular risk factors, including insulin resistance syndrome (IRS) variables plasma total LDL cholesterol concentrations. All factors were strongly related current weight. After adjustment for weight, age, sex, lower was associated with higher systolic blood pressure (P = 0.008), fasting 32-33 split proinsulin concentrations 0.08 0.02), glucose 30 min postglucose 0.06 0.04),...
<h3>Background</h3> There is little data on injuries in elite U18 field hockey players, which limits development of appropriate evidence-based injury prevention strategies. <h3>Objective</h3> Quantify incidence and characteristics players at a major tournament. <h3>Design</h3> Prospective surveillance. <h3>Setting</h3> 2016 EuroHockey Youth Championships, Ireland. <h3>Participants</h3> Sixteen national representative teams; 8 each the boys girls competitions. <h3>Main Outcome...
OBJECTIVE--To see whether reduced rates of fetal growth are related to raised serum cholesterol concentrations in adult life. DESIGN--Follow up study men and women whose size at birth had been recorded. SETTING--Jessop Northern General Hospitals, Sheffield. SUBJECTS--219 born the Jessop Hospital during 1939-40. MAIN OUTCOME MEASURES--Serum total cholesterol, low density lipoprotein apolipoprotein B. RESULTS--Men who a small abdominal circumference This was independent duration gestation....
To examine whether cardiovascular risk factors in women are related to fetal and infant growth.Follow up study of born 1923-30 whose birth weights at one year were recorded.Hertfordshire.297 still living East Hertfordshire.Plasma glucose insulin concentrations during a standard oral tolerance test; fasting plasma proinsulin 32-33 split concentrations; blood pressure; serum total, low density lipoprotein high cholesterol, triglyceride, apolipoprotein A I B fibrinogen factor VII...
STUDY OBJECTIVE--The aim was to determine whether abdominal fatness in adult men is associated with retarded growth fetal life and infancy. DESIGN--This a follow up study of (1) born during 1920-30 whose birthweights weights at one year were recorded the time by health visitors; (2) 1935-43 size birth measured detail. The main outcome measure ratio waist circumference hip girth. SETTING--Hertfordshire Preston, England. SUBJECTS--Subjects 845 east Hertfordshire who still live there; 239...
Both young and advanced maternal age is associated with adverse birth child outcomes. Few studies have examined these associations in low-income middle-income countries (LMICs) none studied adult outcomes the offspring. We aimed to examine both five LMICs.In this prospective study, we pooled data from COHORTS (Consortium for Health Orientated Research Transitioning Societies)-a collaboration of cohorts LMICs (Brazil, Guatemala, India, Philippines, South Africa), which mothers were recruited...
Studies in Britain have shown that adults who had a low birthweight high plasma glucose concentrations 30 and 120 min after an oral load, increased risk of Type 2 diabetes impaired tolerance. Both are common India. To determine whether is associated with reduced tolerance Indian children, tests were carried out on 379 4‐year‐old whose birthweights recorded, Pune, Among 201 children been looked the routine postnatal wards at birth, those lower higher insulin independently their current size (...
OBJECTIVE--To examine whether method of infant feeding is associated with adult serum lipid concentrations and mortality from ischaemic heart disease. DESIGN--Follow up study men born during 1911-30. SETTING--Hertfordshire, England. SUBJECTS--5718 men, for 5471 whom information on had been recorded by health visitors 1314 died. 485 the 1920-30 still living in Hertfordshire who blood measurements. MAIN OUTCOME MEASURES--Death disease; cholesterol apolipoprotein concentrations. RESULTS--474...