A5057788058- Food Allergy and Anaphylaxis Research
- Immunodeficiency and Autoimmune Disorders
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Gut microbiota and health
- Blood disorders and treatments
- Contact Dermatitis and Allergies
- Probiotics and Fermented Foods
- Eosinophilic Esophagitis
- Blood groups and transfusion
- Dermatology and Skin Diseases
- Complement system in diseases
- Hepatitis B Virus Studies
- Platelet Disorders and Treatments
- Tryptophan and brain disorders
- Cytomegalovirus and herpesvirus research
- Diet and metabolism studies
- Pediatric health and respiratory diseases
- Infant Nutrition and Health
- Nutrition, Health and Food Behavior
- Infant Health and Development
- Child Nutrition and Feeding Issues
- Cytokine Signaling Pathways and Interactions
- Pneumocystis jirovecii pneumonia detection and treatment
- Diabetes and associated disorders
Chulalongkorn University
2016-2025
King Chulalongkorn Memorial Hospital
2013-2025
Thai Red Cross Society
2018-2025
Erasmus MC
2015-2022
Erasmus University Rotterdam
2015
This study demonstrates that patient advocacy groups significantly enhance medication availability and improve diagnosis of hereditary angioedema (HAE), particularly in emerging economies within the Asia–Pacific region. supports integrating group involvement into management guidelines, emphasising their role improving access to diagnostics treatment for HAE. Hereditary (HAE) is a rare genetic disorder, where early detection can outcomes reduce mortality [1]. Although (APAC) represents half...
Atopic dermatitis (AD) and food allergy (FA) often originate early in life. Gut microbiota interactions with the host immune system influence development, yet distinct gut microbiome functional profiles individuals AD, FA, or both AD+FA remain underexplored. We investigated microbial colonization proteomic infants compared to age- sex-matched controls from Allergy Development Early Life Associated Factors Thai Birth Cohort (ALICE). microbiomes stool samples were analyzed using 16S...
The in-depth characterization of the recently identified house dust mite (HDM) major allergen Der p 23 requires production its recombinant counterpart because natural is poorly extractable from fecal pellets. This study aimed to provide a detailed physico-chemical (rDer 23) as well investigate IgE reactivity in cohort HDM-allergic patients Thailand.Purified rDer 23, secreted Pichia pastoris, was characterized by mass spectrometry and circular dichroism analyses for chitin-binding activity....
Background: As noted in the reports of ISAAC phase I and III, allergic diseases are very common Thailand, especially among younger children. Objective:The objectives this project to study prevalence severity most diseases.i.e. asthma, rhinoconjunctivitis eczema children living Bangkok. Methods:A cross-sectional multi-centers survey using GAN Core questionnaires on symptoms were completed by parents aged 6-7 years 13-14 years. Results:The total 6,291 eligible for analysis.The cumulative vs....
Abstract Background The house dust mite (HDM ) allergen Der p 13 could be a lipid‐binding protein able to activate key innate signaling pathways in the initiation of allergic response. We investigated IgE reactivity recombinant (rDer 13), its activities, and capacity stimulate airway epithelium cells. Methods Purified rDer was characterized by mass spectrometry, circular dichroism, fluorescence‐based assays, silico structural prediction. IgE‐binding activity allergenic potential were...
Background: Allergic rhinitis (AR) is a disease with high global burden and significant morbidity expense.Risk factors are not well understood.Objective: The objective of our project to study the prevalence risk AR in children living Bangkok area.Methods: A cross-sectional, multi-center survey using new GAN core questionnaires on current was completed by 3,074 parents aged 6-7 years 3,217 13-14 years, directly. Results:The 15.0% (95% confidence interval [CI]:13.8-16.3%)and 17.5% CI:...
Background: Genetic tests for primary immunodeficiency disorders (PIDs) are expensive, time-consuming, and not easily accessible in developing countries. Therefore, we studied the feasibility of a customized single nucleotide variant (SNV) microarray that developed to detect disease-causing variants copy number variation (CNV) patients with PIDs only 40 Euros. Methods: Probes were custom-designed genotype 9,415 277 PID-related genes, added genome-wide Illumina Global Screening Array (GSA)....
Abstract Background Major allergenic components of peanut from distinct geographical regions are widely dispersed. Most the diagnostic studies countries with a high prevalence. There have been only few reports allergen component sensitizations low prevalence allergy. We aimed to investigate roles component‐resolved ( CRD ) differentiate allergy and tolerance in A sian population country Methods Participants sensitization were enrolled. Clinical reactions determined. Skin prick test SPT...
Previous house dust mite subcutaneous immunotherapy (HDM SCIT) placebo-controlled trials have small sample sizes and lack a consensus on baseline treatment.
The infant gut microbiome consists of a complex and diverse microbial community. Comprehensive taxonomic metabolic functional knowledge about communities supports medical biological applications, such as fecal diagnostics. Among the omics approaches available for investigation communities, metaproteomics-based analysis is very powerful approach; under this method, activity explored by investigating protein expression within sample. Through use metaproteomics, study aimed to investigate...
The gut microbiome plays a major role in the maintenance of human health. Characterizing taxonomy and metabolic functions is necessary for enhancing Here, we analyzed metagenomic sequencing, assembly construction meta-gene catalogue with overall aim investigating Thai adults. As result, integrative analysis 16S rRNA gene whole metagenome shotgun (WMGS) sequencing data revealed that dominant bacterial families were Lachnospiraceae Ruminococcaceae Firmicutes phylum. Consistently, across 3.8...
Background: Diagnostic tools to identify allergens that cause allergic symptom is important part in the care of patients.Detection causative allergen can be performed by vivo skin prick test (SPT) or vitro tests for detection serum specific immunoglobulin E (sIgE).The common methods used are fluorescent enzyme assay and immunoblotting assay.Objective: We aim evaluate performance two sIgE determination systems, (Euroline) (ImmunoCAP) comparison with SPT.Methods: Two hundred participants...
Background: The Asia Pacific Society for Immunodeficiencies (APSID) conducted 9 primary immunodeficiency (PID) Schools in 5 years since inauguration to provide PID care training early career physicians Pacific, a region with divergent needs resources and training. Objective: To identify differences patient resource across propose corresponding action plan. Methods: Human Development Index (HDI) indicates the degree of socio-economic development each country/region. Case abstracts presenters’...
The impact of copra meal hydrolysate (CMH) on gut health was assessed by conducting a double-blinded, placebo-controlled study. Sixty healthy adult participants, aged 18–40 years were assigned to daily consume 3 g CMH, 5 CMH or placebo in the form drink powder for 21 days. Consumption at g/d improved defecating conditions reducing stool size and also relieved flatulence bloating symptoms. Fecal samples collected serially baseline before treatment, after treatment 2-week washout period....
Introduction With increased diagnostic capabilities and treatment modalities in the field of primary immunodeficiencies (PID), many pediatric patients survive beyond childhood experience a change care to adult-oriented healthcare system. Unfortunately, transition pathways for PID are less clearly defined, resulting deterioration quality adulthood. Hence, this is first regional study address clinicians’ opinions on practices challenges 7 Southeast Asia (SEA) countries. Methods We adopted...