A5012624961- Drug-Induced Adverse Reactions
- Contact Dermatitis and Allergies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Food Allergy and Anaphylaxis Research
- Urticaria and Related Conditions
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Hemophilia Treatment and Research
- Autoimmune Bullous Skin Diseases
- Dermatology and Skin Diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Meningioma and schwannoma management
- Chronic Lymphocytic Leukemia Research
- Blood disorders and treatments
- Synthesis and Catalytic Reactions
- Mast cells and histamine
- Inflammatory mediators and NSAID effects
- Neuropeptides and Animal Physiology
- Cell Adhesion Molecules Research
- Chronic Myeloid Leukemia Treatments
- Advanced Chemical Sensor Technologies
- Intracranial Aneurysms: Treatment and Complications
- Immunodeficiency and Autoimmune Disorders
- Global Maritime and Colonial Histories
- Pharmaceutical studies and practices
Queen Mary Hospital
2019-2025
University of Hong Kong
2019-2025
University of Hong Kong - Shenzhen Hospital
2025
Chinese University of Hong Kong
2022-2023
Pamela Youde Nethersole Eastern Hospital
2019
University of Calgary
1997
A two-step paradigm for leukocyte recruitment has been established in a number of tissues including the mesentery, skin, and muscle, necessitates an initial rolling step via selectins before firm adhesion integrins. In view many inflammatory diseases that involve liver, we investigated importance hepatic microvasculature compared responses to commonly used mesentery or cremaster microvasculature. We visualized liver using intravital microscopy determined within majority leukocytes adhere...
The impact of recurrent angioedema can be severely debilitating and remains difficult to quantify. Several standardized patient-reported outcome measures (PROMs), including the Angioedema Activity Score (AAS), Quality Life (AE-QoL) questionnaire, Control Test (AECT), have been developed translated into different languages. However, these PROMs yet validated in Chinese individuals, their correlations population remain unknown.
This study demonstrates that patient advocacy groups significantly enhance medication availability and improve diagnosis of hereditary angioedema (HAE), particularly in emerging economies within the Asia–Pacific region. supports integrating group involvement into management guidelines, emphasising their role improving access to diagnostics treatment for HAE. Hereditary (HAE) is a rare genetic disorder, where early detection can outcomes reduce mortality [1]. Although (APAC) represents half...
Hereditary angioedema (HAE) is a rare genetic disorder characterised by recurrent episodes of swelling [1]. In recent years, the humanistic burden HAE, including impaired health-related quality life (HRQoL), work productivity loss and mental health issues, has been increasingly recognised [2, 3]. At societal level, absenteeism impairments also indirectly contribute to disease burden. Yet, causal relationships between these psychological social outcomes are not well-understood in HAE. Thus,...
Urticaria (defined as the presence of hives, angioedema, or both) can be caused by a variety etiologies ranging from more common conditions such chronic spontaneous urticaria (CSU) to rarer hereditary angioedema (HAE). Specialist referral may necessary in cases severe HAE, but access specialist services remains limited certain regions, Greater Bay Area (GBA) China. To address this, Hong Kong-Macau Severe Hives and Angioedema Referral Pathway (SHARP) was initiated Kong Institute Allergy Macau...
Background: Drug allergies (DA) are immunologically mediated adverse drug reactions and their manifestations depend on a variety of drug- patient-specific factors. The dysregulated immune system underpinning rheumatological diseases may also lead to an increase in hypersensitivity reactions, including DA. higher prevalence reported DA, especially anti-microbials, restricts the medication repertoire for these already immunocompromised patients. However, few studies have examined impact DA...
Penicillin allergy testing has been traditionally performed by allergists, but there remains a huge deficit of specialists. A multidisciplinary effort with nonallergists would be invaluable to overcome the magnitude penicillin labels via Hong Kong Drug Allergy Delabelling Initiative (HK-DADI). These consensus statements (CSs) offer recommendations and guidance enable screen for low-risk (LR) patients perform testing.CSs were formulated HK-DADI Group using Delphi method. An agreement was...
Omega-5-gliadin (O5G) allergy, also known as wheat-dependent exercise-induced anaphylaxis, is commonly reported in the Western, but not Asian, populations. Although significant differences O5G allergy presentation across different populations are likely there have been no previous reports on this important topic.To report prevalence and characteristics of Hong Kong (HK) compared with United Kingdom (UK).O5G patients attending Queen Mary Hospital (HK cohort), Guy's St Thomas' Hospital, London...
Purpose The majority of penicillin allergy labels are false, and skin tests (ST) have high negative predictive value (NPV) up to 90%. Piperacillin-tazobactam (PT) has been suspected be an exception this, but existing literature is scarce. We investigate the epidemiology, clinical characteristics, testing outcomes ST in patients referred for PT allergies. Methods records all prescription rates Hong Kong public hospitals (2015-2019) were analyzed. Results There was increase both prescriptions...
Hereditary angioedema (HAE) is a rare condition with presents episodic attacks of angioedema, which often misdiagnosed as allergy, and associated significant morbidity mortality. Misdiagnosed drug allergy (DA) labels are also multitude adverse clinical outcomes. However, the prevalence impact incorrect DA on HAE remains unknown.Data from records all patients in Hong Kong were collected analysed. All their medical recruited to proceed testing, including confirmatory provocation tests...
With no approved long-term prophylaxis (LTP) for the prevention of hereditary angioedema (HAE) attacks in Hong Kong, patients rely on compassionate use programs and drug trials. Moreover, studies regarding efficacy LTP Asia are lacking.Our aim was to assess 2 medications HAE Kong: lanadelumab garadacimab.A prospective study performed. Adult with a diagnosis type I or II 1 more expert-confirmed per month were consecutively recruited. The had been receiving treatment at least 6 months....
Introduction Olfactory dysfunction (OD) is common among patients with chronic rhinosinusitis (CRS). Validated and culturally specific tests, such as the “Sniffin’ Sticks” test (SST) TIB Smell Identification Test (TIBSIT), are crucial for diagnosis monitoring of OD. However, they have not been utilised in Hong Kong Chinese their correlations unknown. Methods Twelve CRS twenty healthy volunteers were prospectively recruited from a joint allergy-otorhinolaryngology clinic performed both SST...
A 37-year-old man presented with a large-bowel obstruction. He reported having had unexplained episodes of abdominal pain and swelling in his hands, feet, scrotum, without hives or itching, since 18 years age.