A5090916588- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Rheumatoid Arthritis Research and Therapies
- Liver Disease and Transplantation
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Heavy Metal Exposure and Toxicity
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Systemic Lupus Erythematosus Research
- Ultrasound and Hyperthermia Applications
- Liver physiology and pathology
- MRI in cancer diagnosis
- Multiple and Secondary Primary Cancers
- Blood Pressure and Hypertension Studies
- Gout, Hyperuricemia, Uric Acid
- Autoimmune and Inflammatory Disorders Research
- Diet and metabolism studies
- Drug Transport and Resistance Mechanisms
- Atrial Fibrillation Management and Outcomes
- Cancer Genomics and Diagnostics
- Trace Elements in Health
- Colorectal Cancer Treatments and Studies
- Antiplatelet Therapy and Cardiovascular Diseases
Hospital for Sick Children
2025
University of Hong Kong
2015-2024
Hong Kong Sanatorium and Hospital
2020-2024
Chinese University of Hong Kong
2012-2024
Queen Mary Hospital
2012-2023
Albert Einstein College of Medicine
2023
Cheung Kong Graduate School of Business
2020
Hong Kong College of Technology
2017
MedCom
2017
Cedars-Sinai Medical Center
2012
BackgroundLead is toxic and affects neurodevelopment in children even at low levels. There has been a long-term effort the United States to reduce exposure lead environment. We studied latest US population blood levels analyzed its trend.MethodBlood 63,890 participants of National Health Nutrition Examination Survey 1999-2014 were using SPSS Complex Samples v22.0 (IBM Corp, Armonk, NY).ResultsMean 95% confidence intervals (CIs) 1.65 μg/dL (1.62-1.68), 1.44 (1.42-1.47), 1.43 (1.40-1.45), 1.29...
Obesity is a major health problem worldwide. Although diet and physical activity are crucial in the management of obesity, long-term success rate low. Therefore antiobesity drugs great interest, especially when lifestyle modification has failed. As obesity not an immediate life-threatening disease, these required to be safe. Antiobesity that have been developed so far limited efficacies considerable adverse effects affecting tolerability safety. Therefore, most withdrawn. Fenfluramine...
Obesity is a public health crisis in the USA. This study aimed to estimate prevalence of obesity and severe US children adolescents identify novel targetable risk factors associated with childhood obesity.
The risk of cardiovascular events (CVEs) with alendronate use in real-world hip fracture patients is unknown. This study aimed to investigate the CVE and without fracture. We conducted a retrospective cohort using population-wide database managed by Hong Kong Hospital Authority. Patients newly diagnosed from 2005 through 2013 were followed until November 6, 2016. Alendronate other antiosteoporosis medications during period examined. matched treated nontreated based on time-dependent...
Abstract Lead is a heavy metal without biological role. High level of lead exposure known to be associated with hypertension, but the risk at low levels uncertain. In this study, data from US NHANES 1999–2016 were analyzed. Adults blood and pressure measurements, or self-reported hypertension diagnosis, included. If not already diagnosed, was defined according AHA/ACC 2017 guideline. Results analyzed using R statistics version 3.5.1 sample weight adjustment. Logistic regression used study...
Abstract Objective To determine the incidence and prevalence of gout in general population utilisation urate-lowering therapy (ULT) among patients with Hong Kong. Methods A total 2,741,862 subjects who attended any outpatient clinics or accident emergency department (with without hospitalisation) 2005 did not die before 2006 were identified from Clinical Data Analysis Reporting System (CDARS) Hospital Authority All followed until end 2016 death. Demographics, diagnosis gout, serum urate...
Background: Drug allergies (DA) are immunologically mediated adverse drug reactions and their manifestations depend on a variety of drug- patient-specific factors. The dysregulated immune system underpinning rheumatological diseases may also lead to an increase in hypersensitivity reactions, including DA. higher prevalence reported DA, especially anti-microbials, restricts the medication repertoire for these already immunocompromised patients. However, few studies have examined impact DA...
Immunoglobulin G4-related disease remains an under-recognised and evolving disease. Local data are sparse previous publications have been limited to individual case reports or series only. We conducted this study review the clinical features, treatment practices, factors associated with multisystem involvement in Hong Kong. described features modalities of largest cohort immunoglobulin our locality thus far.We retrospectively evaluated all patients between January 2003 December 2015 Queen...
Venetoclax has been approved in the United States, Europe, Canada, and Australia for appropriate patients with difficult-to-treat chronic lymphocytic leukemia (CLL). The objective of this phase 1 study was to evaluate pharmacokinetics venetoclax Chinese subjects inform dose selection a 2 relapsed/refractory (R/R) CLL China. Twelve healthy first-generation Han received single 100-mg following low-fat breakfast. Pharmacokinetic parameters were estimated using noncompartmental methods. After...
Purpose: Biological therapies targeting eosinophils have been shown to be effective in treating patients with severe eosinophilic asthma. Benralizumab (Fasenra ® , AstraZeneca) is a humanized monoclonal antibody binding the alpha subunit of interleukin-5 receptor, which rapidly depletes via antibody-dependent cellular cytotoxicity. The aim this Phase 1 study was assess safety, tolerability, and pharmacokinetics benralizumab healthy Chinese individuals. Materials Methods: In randomized,...
Abstract Objectives This study explored whether the excess cardiovascular (CV) disease (CVD) risk in RA could be ameliorated by suppression of inflammation using a treat-to-target (T2T) approach. We compared CV event (CVE) incidence among ERA patients managed T2T strategy with factor-matched non-RA population and historical cohort (HRA). Methods was an observational city-wide hospital data registry. received management while HRA routine care. Each ERA/HRA patient matched to three controls...
Cystic artery pseudoaneurysm is a rare condition, which usually arises from the complication of gallstone disease. Patients may present with Quinke's triad (epigastric pain, obstructive jaundice, and gastrointestinal bleeding). The results can be fatal if ruptured pseudoaneurysm. We report patient who presented upper bleeding, later diagnosis was confirmed computer tomography scan abdomen three-vessel angiogram. Endovascular intervention attempted. Although it failed, eventually cured an...