A5037376812- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Psoriasis: Treatment and Pathogenesis
- Bone and Joint Diseases
- Systemic Sclerosis and Related Diseases
- Alzheimer's disease research and treatments
- Autoimmune and Inflammatory Disorders Research
- COVID-19 Clinical Research Studies
- Radiomics and Machine Learning in Medical Imaging
- Orthopedic Infections and Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Musculoskeletal synovial abnormalities and treatments
- Biomarkers in Disease Mechanisms
- Child Nutrition and Feeding Issues
- Osteomyelitis and Bone Disorders Research
- Neuroscience and Neuropharmacology Research
- Biosimilars and Bioanalytical Methods
- Retinal and Optic Conditions
- Cardiovascular Health and Disease Prevention
- S100 Proteins and Annexins
- Spine and Intervertebral Disc Pathology
- Cholinesterase and Neurodegenerative Diseases
- Lymphoma Diagnosis and Treatment
- Osteoarthritis Treatment and Mechanisms
Chinese University of Hong Kong
2016-2025
Health First
2025
Prince of Wales Hospital
2016-2024
Antioch University Seattle
2024
Hong Kong University of Science and Technology
2021
University of Hong Kong
2021
Shenzhen Technology University
2021
University College London
2021
Therapeutics Clinical Research
2020
Novartis (Switzerland)
2003
Perturbed Ca<sup>2+</sup> homeostasis is a common molecular consequence of familial Alzheimer's disease-linked presenilin mutations. We report here the interaction large hydrophilic loop region 2 (PS2) with sorcin, penta-EF-hand Ca<sup>2+</sup>-binding protein that serves as modulator ryanodine receptor intracellular Ca<sup>2+</sup>channel. The association endogenous sorcin and PS2 was demonstrated in cultured cells human brain tissues. Membrane-associated subset functional complexes were...
To evaluate coronary atherosclerosis in patients with psoriatic arthritis (PsA) and control subjects using CT angiography (CCTA).Ninety consecutive PsA (male: 56(62.2%); 50.3±11.1 years) were recruited. 240 controls 137(57.1%); 49.6±10.7 without known cardiovascular (CV) diseases who underwent CCTA due to chest pain and/or multiple CV risk factors recruited for comparison.Patients matched age, gender traditional (all p>0.2). The prevalence of overall plaque (54(60%)/84(35%), p<0.001),...
Objectives This study aimed to ascertain the effect of secukinumab on erosion and enthesiophyte progression in psoriatic arthritis (PsA) by high‐resolution peripheral quantitative computed tomography (HR‐pQCT). Methods was a phase 4, double‐blind, randomized, placebo‐controlled trial. Patients with active PsA ≥ 1 metacarpophalangeal joints (MCPJ) 2‐4 were randomised 1:1 ratio subcutaneous or placebo. HR‐pQCT MCPJ performed at baseline, week 24 48 The primary outcome changes volume erosions...
This study aimed to evaluate the short-term patient satisfaction, compliance, disease control, and infection risk of telemedicine (TM) compared with standard in-person follow-up (FU) for patients lupus nephritis (LN) during COVID-19 pandemic.
Objective. To test the performances of established cardiovascular (CV) risk scores in discriminating subclinical atherosclerosis (SCA) patients with psoriatic arthritis. Methods. These were calculated: Framingham score (FRS), QRISK2, Systematic COronary Risk Evaluation (SCORE), 10-year atherosclerotic disease algorithm (ASCVD) from American College Cardiology and Heart Association, European League Against Rheumatism (EULAR)–recommended modified versions (by 1.5 multiplication factor, m-)....
Objective To examine whether Disease Activity in Psoriatic Arthritis (DAPSA) reflecting the inflammatory component of psoriatic arthritis (PsA) can predict cardiovascular (CV) events independent traditional CV risk factors and subclinical carotid atherosclerosis. Methods A cohort analysis was performed patients with PsA who had been followed since 2006. The outcome interest first event. Four different disease (CVD) scores DAPSA were computed at baseline. presence plaque (CP) intima-media...
To investigate the effects of achieving minimal disease activity (MDA) on progression subclinical atherosclerosis and arterial stiffness in patients with psoriatic arthritis (PsA).A total 101 consecutive PsA were recruited for this prospective cohort study. All received protocolized treatment targeting MDA a period 2 years. High-resolution carotid ultrasound markers assessed annually. The primary outcome measure was effect at 12 months (MDA group) over 24 months. Secondary objectives to...
Background : Alzheimer's disease (AD) places a significant burden on health care systems worldwide. As new treatments are developed, their cost-effectiveness is often assessed to help professionals make informed decisions. In addition the more common practice of assessing direct medical costs, indirect including time spent in caregiving, should be evaluated. Methods This study examined potential effects dual cholinesterase inhibitor rivastigmine (Exelon) caregivers patients with AD. Results...
Abstract Psoriatic arthritis (PsA) patients have increased risk of both atherosclerosis and osteoporosis. Previous studies revealed that IL-33/ST2 axis may be related to conditions; however, these associations were never evaluated in a single patients’ group. Here we explored the association among plasma levels IL-33 its decoy receptor soluble ST2 (sST2), carotid plaque determined by ultrasound volumetric bone mineral density (vBMD)/microstructure distal radius measured high-resolution...
Objective To evaluate the effects of denosumab on erosion healing at 2–4 metacarpophalangeal (MCP) head as determined by high-resolution peripheral quantitative CT (HR-pQCT) in patients with rheumatoid arthritis (RA) stable disease. Methods This was a randomised, placebo-controlled, double-blind study. Patients RA disease activity score 28 joints (DAS28) ≤5.1 were randomised (1:1) to subcutaneous 60 mg or placebo once every 6 months for 24 months. The primary outcome MCP HR-pQCT 12 and joint...
Objective. To determine the efficacy of 2 tight control treatment strategies aiming at Simplified Disease Activity Score (SDAI) remission (SDAI ≤ 3.3) compared to 28-joint count (DAS28) (DAS28 < 2.6) in prevention arterial stiffness patients with early rheumatoid arthritis (RA). Methods. This was an open-label study which 120 RA were randomized receive 1 year treatment. Group (n = 60) aimed achieve SDAI 3.3 and 60), DAS28 2.6. Pulse wave velocity (PWV) augmentation index (AIx) measured...
Psoriatic arthritis (PsA) is associated with accelerated atherosclerosis due to underlying inflammation. Whether inflammatory burden and drugs used suppress inflammation over time are cardiovascular (CV) events remained unclear. This study aims examine the time-varying effect of C-reactive protein (CRP) levels use drugs, including non-steroidal anti-inflammatory (NSAIDs) disease modifying anti-rheumatic on risk CV independent traditional factors in PsA patients.A retrospective cohort...
Abstract Objectives This study explored whether the excess cardiovascular (CV) disease (CVD) risk in RA could be ameliorated by suppression of inflammation using a treat-to-target (T2T) approach. We compared CV event (CVE) incidence among ERA patients managed T2T strategy with factor-matched non-RA population and historical cohort (HRA). Methods was an observational city-wide hospital data registry. received management while HRA routine care. Each ERA/HRA patient matched to three controls...
Patients with systemic lupus erythematous were vulnerable to severe coronavirus disease 2019 infection and the negative impact of disrupted healthcare delivery. Telemedicine has been a popular alternative standard in-person care during pandemic despite lack evidence.This was 1-year pragmatic randomized-controlled trial. followed at nephritis clinic randomized either telemedicine or follow-up in 1:1 ratio. group up via videoconferencing. Standard patients continued conventional outpatient...
Objectives To elucidate the association between different disease activity levels over time on long-term vascular outcomes in patients with early rheumatoid arthritis (ERA). Methods This was a 5-year prospective study. Patients consecutive ERA without overt cardiovascular (CVD) were recruited to receive 1 year of tight-control treatment followed by standard-of-care management. High-resolution carotid ultrasound assessed at baseline and 5. The primary outcome subclinical atherosclerosis...
Although the short-term effects of tumor necrosis factor alpha (TNF-α) and interleukin-17A (IL-17A) inhibition on structural changes in psoriatic arthritis (PsA) using high-resolution peripheral quantitative computed tomography (HR-pQCT) have been reported, no studies investigated long-term PsA patients receiving routine care. We reported longitudinal erosions enthesiophytes HR-pQCT their relationship with treatments over a 5-year period.HR-pQCT examination at second third metacarpal heads...
Objectives This study aimed to assess the performance of carotid ultrasound (US) parameters alone or in combination with Framingham Risk Score (FRS) discriminating patients psoriatic arthritis (PsA) and without coronary artery disease (CAD). Methods Ninety-one PsA (56 males; age: 50±11 years, duration: 9.4±9.2 years) overt cardiovascular (CV) diseases were recruited. Carotid intima-media thickness (cIMT), presence plaque total area (TPA) was determined by high-resolution US. CAD defined as...
Abstract Objective PsA patients who achieved sustained minimal disease activity (sMDA) had less subclinical atherosclerosis progression. The vascular effects of achieving other potential treatment targets, including the Disease Activity Score (PASDAS) and in (DAPSA) score, remained uncertain. This study aimed to compare different targets patients. Method is a post hoc analysis 2 year treat-to-target at MDA. A total 101 consecutive without overt cardiovascular were recruited. High-resolution...
Whether calprotectin could play a role in augmenting cardiovascular (CV) risk patients with psoriatic arthritis (PsA) remains uncertain. The aim of this study is to elucidate the association between serum level and subclinical atherosclerosis patient PsA.Seventy-eight PsA (age: 52 ± 10 years, 41 [52.6%] male) without CV disease were recruited into cross-sectional study. Carotid intima-media thickness (cIMT) presence plaque determined by high-resolution ultrasound. Calprotectin levels...
To investigate the relationship between disease-related parameters and joint space width (JSW) on high-resolution peripheral quantitative computed tomography (HR-pQCT) in psoriatic arthritis (PsA) patients.PsA patients who underwent HR-pQCT examination of second to fourth metacarpophalangeal (MCPJ 2-4) were recruited this cross-sectional study. The metrics included volume (JSV), mean, minimum, maximum JSW, JSW asymmetry, distribution. Correlation analysis multivariable linear regression...