OBJECTIVE: This report provides a description of the prevalence and clinical features major depressive syndrome Alzheimer’s disease using data derived from structured diagnostic assessments 243 patients with probable 151 nondemented elderly comparison subjects. METHOD: Subjects were characterized by consortium four research centers Geriatric Psychiatry Branch National Institute Mental Health. All sites administered Clinical Assessment Depression in Dementia, structured, anchored interview...

Identification of the neuropathological lesions that are most closely associated with earliest symptoms Alzheimer disease (AD) is crucial to understanding process and development treatment strategies affect its progress. Do classical AD precede, follow, or occur in synchrony signs cognitive deterioration?We examined extent neuritic plaque (NP) formation 5 neocortical regions hippocampus, entorhinal cortex, amygdala 66 elderly subjects no dementia, questionable mild dementia as assessed using...

Background. We examined the prevalence of comorbid medical illnesses in Alzheimer's disease (AD) patients at different severity levels. also effect cumulative comorbidity on cognition and function.

The DSM-IV mood disorders field trial, a multisite collaborative study, was designed to explore the reliability of course-based diagnostic classification system for major depression, evaluate symptom criteria dysthymia, and need additional categories milder forms disorder (e.g., minor recurrent brief depression). Five hundred twenty-four depressed subjects were recruited from inpatient, outpatient, community settings at five sites evaluated with structured interviews according DSM-III...

The relationship between neuropathological lesions and mild, "preclinical," cognitive impairments of Alzheimer disease is poorly understood. Identification the that are most closely associated with earliest symptoms crucial to understanding process development treatment strategies affect its progression.We examined extent neurofibrillary tangles (NFTs) in 4 neocortical regions, hippocampus, entorhinal cortex, amygdala 65 elderly subjects no dementia, questionable mild or moderate dementia as...

Background. In cross-sectional and longitudinal studies, type 2 diabetes has been positively associated with the risk of Alzheimer's disease (AD). The present descriptive study compared diabetic nondiabetic subjects on severity neuritic plaques neurofibrillary tangles (NFTs) in cerebral cortex hippocampus.

This prospective study investigated the relationship between chaplain visits and patient satisfaction, as measured by Hospital Consumer Assessment of Healthcare Providers Systems (HCAHPS) Press Ganey surveys from 8,978 patients who had been discharged a tertiary care hospital. Controlling for patients' age, gender, race, ethnicity, language, education, faith, general health status, medical conditions, increased willingness to recommend hospital, both HCAHPS survey (regression coefficient =...

Most instruments that measure the impairments associated with Alzheimer's disease assess symptom severity. Little attention has been paid to illness's impact on time formal and informal caregivers spend caring for individuals. A tool measures spent caregiving would help determine economic of illness. The Caregiver Activity Survey (CAS) was developed aiding patients their day-to-day activities.The test-retest reliability CAS assessed during a 3-week study 42 caregivers. validated Disease...

Eleven percent (N = 25) of 232 dementia patients seen in an active geropsychiatry service also met criteria for major depression. Ten with dementia/depression were prospectively compared 10 non-depressed demented and 33 nondemented depressed on pretreatment posttreatment ratings depression cognition/memory. Seventy 7) the group 73% 24) depression-only responded to antidepressant therapy. Signs symptoms complicating similar depressive phenomena group. Depression appeared lower performance...

OBJECTIVE : To investigate the frequency and longitudinal course of symptoms depression, agitation, psychosis in a longitudinally studied sample patients with Alzheimer's disease (AD). DESIGN Longitudinal study AD follow‐up assessments at 6‐month intervals for an average more than 3 years. SETTING Disease Research Center Mount Sinai Medical Bronx VA Center, New York. PARTICIPANTS A total 153 patients. MEASUREMENTS Blessed Test Information, Memory Concentration (BIMC) Assessment Scale...

Background The COVID-19 pandemic has resulted in increased strain on health care systems and negative psychological effects workers (HCWs). This is anticipated to result long-term mental the population, with HCWs representing a particularly vulnerable group. scope of necessitates development scalable platform provide services large numbers at-risk or affected individuals. Mount Sinai Health System New York City was at epicenter United States. Objective Center for Stress, Resilience, Personal...

OBJECTIVES: The goals of this study were to establish the frequency palliative and aggressive treatment measures among patients with without dementia during last six months life, identify relationships between severity care, determine whether patterns have changed over time. METHODS: Antemortem data for 279 24 control who brought autopsy in chronic care facilities 1985 2000 reviewed. was defined by scores on Clinical Dementia Rating scale. Data use systemic antibiotics (designated as an...

<h3>Context</h3> The role of genetic factors in Alzheimer disease (AD) varies across the late life span, complicating efforts to quantify risk AD for relatives probands with AD. <h3>Objectives</h3> To visualize changing levels familial according proband onset age and at-risk relative determine familiality at <h3>Design</h3> A retrospective, informant-based family study. <h3>Setting, Patients, Other Participants</h3> Siblings parents (relatives = 4687; 904), ascertained geriatric clinic...

The relationships of serum lipids with Alzheimer's disease (AD) and other dementias in very old patients are not clear. All residents an academic nursing home were studied clinically for dementia lipids. those autopsied over a 7.7-year period had apolipoprotein E (apoE) genotyping detailed neuropathological examination. Those pathologically defined criteria AD (n = 84) compared to all others who also clinical but did show changes 22). In contrast most reports AD, total cholesterol (TC) low...

Deficits in somatostatin-like immunoreactivity (SLI) and corticotropin-releasing factor (CRF-IR) are well recognized as prominent neurochemical deficits Alzheimer disease (AD). The question of whether these profound neuropeptidergic found patients with end-stage extend into those much earlier is relatively unanswered. To determine the relation between level SLI CRF-IR different cerebrocortical regions to earliest signs cognitive deterioration AD.We examined levels 9 neocortical brain 66...

<h3>Context</h3> Lewy bodies (LBs) are intraneuronal inclusions in the brain that have been increasingly recognized as neuropathological lesions with relevance not only to Parkinson disease but also Alzheimer disease. However, degree which density of LBs contributes severity dementia has clear. <h3>Objective</h3> To determine LB "burden" dementia. <h3>Design</h3> Brain specimens were examined from 273 consecutive autopsies elderly subjects residing a nursing home. The numbers and densities...

There is an acute need to define the specific skills that make chaplains integral healthcare team. This prospective study attempts identify those may be chaplains, for whom no other member of health care team has similar training, and examine if these have a differential effect on patient satisfaction. A total 59 interventions were identified grouped into 10 categories by focus groups comprised chaplains. Subsequently, Principal Component Analysis yielded two independent variables; 1...

We examined the relationship between CSF amyloid beta peptide (A beta) concentration and AD severity in 31 probable patients explored whether APOE genotype modifies this relationship.A deposition brains has been correlated with disease APOE-epsilon4 allele frequency. Few studies have effects of on A an antemortem sample.Patients carried clinical diagnosis did not serious medical illness, current or past mood disorder, schizophrenia alcoholism, psychotic features. The Mini-Mental State...

Abstract Objective To assess the prevalence, diagnosis and treatment of depression among dementia patients normal controls in chronic care facilities last six months life. Method We reviewed perimortal data concerning severity, depressive symptoms diagnoses, medication use for 279 24 brought to autopsy through an Alzheimer's Disease Resource Center. Results Major was highly prevalent both This under‐diagnosed by physicians. Documentation medical support staff has improved over time. However,...