A5101547393- Schizophrenia research and treatment
- Diet and metabolism studies
- Alzheimer's disease research and treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Dementia and Cognitive Impairment Research
- Genetic Associations and Epidemiology
- Traumatic Brain Injury Research
- Bipolar Disorder and Treatment
- Respiratory Support and Mechanisms
- Neurological disorders and treatments
- Kawasaki Disease and Coronary Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Primary Care and Health Outcomes
- Mitochondrial Function and Pathology
- Gastroesophageal reflux and treatments
- Coronary Interventions and Diagnostics
- Chronic Disease Management Strategies
- Celiac Disease Research and Management
- Psychosomatic Disorders and Their Treatments
- HIV/AIDS Research and Interventions
- Genetics and Neurodevelopmental Disorders
- Sports Performance and Training
- Sarcoma Diagnosis and Treatment
- Obsessive-Compulsive Spectrum Disorders
- Meta-analysis and systematic reviews
Roche (Canada)
2024
Queen Mary University of London
2023
Royal North Shore Hospital
2005-2022
The University of Texas Health Science Center at San Antonio
2019
The University of Texas Health Science Center at Houston
2018
Florida College
2017
University of Florida
2017
Malcom Randall VA Medical Center
2017
Cambridge University Hospitals NHS Foundation Trust
2015
Royal Alexandra Hospital
2014
Comorbidities associated with systemic inflammation including cardiovascular disease (CVD), stroke and diabetes mellitus (DM) are common among individuals chronic obstructive pulmonary (COPD). A study was undertaken to quantify the burden of comorbidity determine risk first acute arteriovascular events COPD.The computerised primary care records 1,204,100 members general population aged ≥ 35 years on 25 February 2005 were searched for recordings each disease. Data analysed using multivariate...
We have undertaken a large case–control study using the UK General Practice Research Database to quantify relative contributions of common risk factors for carpal tunnel syndrome (CTS) in community. Cases were patients with diagnosis CTS and, each, four controls individually matched by age, sex and general practice. Our dataset included 3,391 cases, which 2,444 (72%) women, mean age at 46 (range 16–96) years. Multivariate analysis showed that associated previous wrist fracture (OR = 2.29),...
It has been suggested that vascular disease mortality may be reduced in coeliac because of lower levels blood pressure, cholesterol and body mass.To examine whether people with are at risk various diseases.We identified 3,790 adults diagnosed 17,925 age- sex-matched controls the General Practice Research Database. We estimated odds ratios for hypertension, hypercholesterolaemia atrial fibrillation hazard myocardial infarction stroke.Adults disease, compared controls, were less likely to have...
Abstract Purpose Previous studies have shown that treatment with gastric acid suppressants may be associated an increased risk of pneumonia whilst the use statins and ACE inhibitors (ACEI) decrease acquiring pneumonia. The evidence is conflicting however. Our aim was to investigate effect these drugs on using population‐based data from UK. Methods We conducted a general case–control study health improvement network (THIN), comprehensive UK practice database. Conditional multiple logistic...
<b><i>Background: </i></b> Myoclonus-dystonia (M-D) is a movement disorder with involuntary jerks and dystonic contractions. Autosomal dominant alcohol-responsive M-D associated mutations in the ε-sarcoglycan gene (<i>SGCE</i>) (six families) missense change D2 dopamine receptor (<i>DRD2)</i>gene (one family). <b><i>Objective: To investigate clinical phenotype including motor symptoms, psychiatric disorders, neuropsychological deficits. <b><i>Methods: Fifty individuals three families were...
Abstract Myoclonus‐dystonia is a movement disorder associated with mutations in the ε‐sarcoglycan gene ( SGCE ) most families and DRD2 DYT1 genes two single families. In both of latter families, we also found mutation . The molecular mechanisms through which detected may contribute to myoclonus‐dystonia remain be determined.
<h3>Context</h3> The role of genetic factors in Alzheimer disease (AD) varies across the late life span, complicating efforts to quantify risk AD for relatives probands with AD. <h3>Objectives</h3> To visualize changing levels familial according proband onset age and at-risk relative determine familiality at <h3>Design</h3> A retrospective, informant-based family study. <h3>Setting, Patients, Other Participants</h3> Siblings parents (relatives = 4687; 904), ascertained geriatric clinic...
Abstract Background Pneumonia is a common diagnosis in general practice the United Kingdom. Previous studies suggest that commonly prescribed drugs may influence pneumonia mortality. Aim We investigated whether statins, angiotensin converting enzyme inhibitors (ACEIs), proton pump (PPIs) and Histamine‐2‐receptor antagonists (H 2 RAs) have an impact on short‐term long‐term mortality cases. Design of Study Population‐based cohort study Settting Kingdom Methods Data 3681 cases above age 40...
Background: Despite the role of primary care in falls pathway, there are almost no data on extent seen general practices.
There remains a proportion of patients with unfavorable outcomes after aneurysmal subarachnoid hemorrhage, particular relevance in those who present good clinical grade. A forewarning at risk provides an opportunity towards more intensive monitoring, investigation, and prophylactic treatment prior to the manifestation advancing cerebral injury.To assess whether biochemical markers sampled first days initial hemorrhage can predict poor outcome.All recruited multicenter Simvastatin Aneurysmal...
ABSTRACT Background The April 2004 contract for UK general practitioners (GPs) is an ambitious attempt to produce substantial changes in clinical practice. We investigated the impact of this on delivery primary care smoking cessation interventions. Methods analysed data from patients' medical records that were held within a large database called Health Improvement Network (THIN). calculated each year between 1990 and 2005 quarter‐year 2003 incidence recording status and, smokers, receipt...
Myoclonus-dystonia has recently been associated with mutations in the epsilon-sarcoglycan gene (SCGE) on 7q21. Previously, authors reported a patient myoclonus-dystonia and an 18-bp deletion DYT1 9q34. The have now re-evaluated harboring this for SGCE identified missense change. In current study, describe clinical details of family carrying two different dystonia genes. Further analysis these separately together cell culture animal models should clarify their functional consequences.
We attempted to identify a locus for schizophrenia and related disorders in 24 nuclear families of schizophrenic probands using predefined classification system affected cases that included those most clearly identified as sharing genetic relationship with schizophrenia—schizoaffective disorder schizotypal personality disorder. Initially, we evaluated 8 markers on chromosome 5 the first 12 available genotyping diagnostic assessments and, assuming autosomal dominant transmission, found lod...
The introduction of the NICE guideline on COPD and inclusion in new Quality Outcomes Framework (QOF) were designed to improve care people with primary UK.We have investigated whether these initiatives had an impact prevalence COPD, recording spirometry data use combined inhaled corticosteroid/long-acting beta-agonist inhalers.We analysed from Health Improvement Network for year before after guideline.Data using logistic regression.The 2003 was 1.27%, this increased by 14-1.45% 2005. risk...
Background:The incidence of Alzheimer disease (AD) peaks after 85 years age.Although genetic factors are implicated in AD with substantially earlier onset, the familial characteristics high-incidence very late-onset (VLOAD, defined here as onset age Ն85 years) remain unknown.Methods: We collected information pertaining to cognitive status and demographics 809 parents siblings 144 VLOAD probands, 4235 793 earlier-onset 7646 1493 nondemented elderly probands.Cumulative risks 5-year...