A5100324271- Genomics and Rare Diseases
- Genetics and Neurodevelopmental Disorders
- Alzheimer's disease research and treatments
- Metabolism and Genetic Disorders
- Cardiac Ischemia and Reperfusion
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Anesthesia and Neurotoxicity Research
- Fungal Biology and Applications
- Heme Oxygenase-1 and Carbon Monoxide
- Forensic and Genetic Research
- Neurobiology and Insect Physiology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neural Engineering
- Healthcare and Venom Research
- Adipokines, Inflammation, and Metabolic Diseases
- Neuroscience and Neuropharmacology Research
- Hemoglobin structure and function
- Mycobacterium research and diagnosis
- Advanced Memory and Neural Computing
- Plant Pathogens and Fungal Diseases
- Mitochondrial Function and Pathology
- Neuroscience of respiration and sleep
- Biochemical effects in animals
- RNA Interference and Gene Delivery
Chinese Academy of Medical Sciences & Peking Union Medical College
2008-2025
Southern Medical University
2022-2024
Wuhan University
2022-2024
Guangzhou Medical University
2014-2023
Second Affiliated Hospital of Guangzhou Medical University
2014-2023
Children's Hospital of Zhejiang University
2023
Institute of Pomology
2023
Chinese Academy of Agricultural Sciences
2023
Jinan University
2020-2023
The People's Hospital of Guangxi Zhuang Autonomous Region
2023
The success of prenatal carrier screening as a disease prevention strategy in the Ashkenazi Jewish (AJ) population has driven expansion panels disease-causing founder mutations have been identified. However, frequencies many these not reported large AJ cohorts. We determined over 100 for 16 recessive disorders New York metropolitan area population. Among 100% AJ-descended individuals, resulted ∼1 3.3 being one and 24 two diseases. ranged from 0.066 (1 15.2; Gaucher disease) to 0.006 168;...
Abstract Cancer-associated cachexia is a multi-organ weight loss syndrome, especially with wasting disorder of adipose tissue and skeletal muscle. Small extracellular vesicles (sEVs) serve as emerging messengers to connect primary tumour metabolic organs exert systemic regulation. However, whether how tumour-derived sEVs regulate white (WAT) browning fat poorly defined. Here, we report breast cancer cell-secreted exosomal miR-204-5p induces hypoxia-inducible factor 1A (HIF1A) in WAT by...
<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> This paper presents a CMOS imager chip that is aimed at subretinal implantation for partially restoring human vision. It has low supply voltage (<formula formulatype="inline"><tex Notation="TeX">$\pm$</tex></formula> 2 V) and all DC free terminals long life wired operation. Stimulation increased to approximately 4 <formula Notation="TeX">${\rm V}_{\rm pp}$</tex></formula> by drop design. 40 x...
Evidence of oxidative stress and the accumulation fibrillar amyloid beta proteins (Abeta) in senile plaques throughout cerebral cortex are consistent features pathology Alzheimer disease. To define a mechanistic link between these two processes, various aspects relationship lipid membrane damage amyloidogenesis were characterized by chemical physical techniques. Earlier studies this demonstrated that oxidatively damaged synthetic membranes promoted amyloidogenesis. The reported herein...
Hypoxia administered after transient global cerebral ischemia (tGCI) has been shown to induce neuroprotection in adult rats, but the underlying mechanisms for this protection are unclear. Here, we tested hypothesis that hypoxic postconditioning (HPC) induces through upregulation of hypoxia-inducible factor 1α (HIF-1α) and vascular endothelial growth (VEGF), involves phosphatidylinositol-3-kinase (PI3K), p38 mitogen–activated protein kinase (p38 MAPK), mitogen-activated kinase/extracellular...
Early brain injury (EBI) is considered a major contributor to the high morbidity and mortality associated with subarachnoid haemorrhage (SAH). Both of sterile inflammation apoptosis are important causes EBI. Recently, it was confirmed that thioredoxin-interacting protein (TXNIP) not only participates in inflammatory amplification but also stimulates signalling cascade pathway. However, whether effects TXNIP influence pathogenesis SAH remains unclear. Here, we hypothesize activity induced by...
Autophagy disruption leads to neuronal damage in hypoxic-ischemic brain injury. Rab7, a member of the Rab GTPase superfamily, has unique role regulation autophagy. Hypoxic preconditioning (HPC) provides neuroprotection against transient global cerebral ischemia (tGCI). However, underlying mechanisms remain poorly understood. Thus, current study explored potential molecular mechanism neuroprotective effect HPC by investigating how Rab7 mediates autophagosome (AP) maturation after tGCI adult...
Polyporus umbellatus is a medicinal fungus primarily used for diuresis, with its sclerotium serving as the component. The growth and development of sclerotia are reliant on symbiotic relationship Armillaria. However, impact different Armillaria species yield quality remains unclear. In this study, three strains, A35, A541, A19, were identified through TEF-1α sequence analysis phylogenetic classification. These strains classified into distinct species: A35 A. ostoyae, A541 gallica, while...
Abstract Myoclonus‐dystonia is a movement disorder associated with mutations in the ε‐sarcoglycan gene ( SGCE ) most families and DRD2 DYT1 genes two single families. In both of latter families, we also found mutation . The molecular mechanisms through which detected may contribute to myoclonus‐dystonia remain be determined.
In the course of our search for anti-dormant mycobacterial substances from marine organisms, we previously isolated three new aminolipopeptides, named trichoderins A, A1 and B, culture sponge-derived fungus Trichoderma sp. determined their chemical structures. To identify gene that could confer a resistance to trichoderin prepared transformants Mycobacterium (M.) smegmatis, which were transformed with genomic DNA library M. bovis BCG constructed in multi-copy shuttle cosmid pYUB145. Then,...
Abstract Transcription factor EB (TFEB) is a master regulator of autophagy and lysosomal biogenesis. Here, silver nanoparticles (Ag NPs)‐induced cytoprotective required TFEB shown. Ag NPs‐induced nucleus translocation through well‐established mechanism involving dephosphorylation at serine‐142 serine‐211 but independent both the mTORC1 ERK1/2 pathways. precedes induced by NPs leads to enhanced expression autophagy‐essential genes. Knocking down attenuates induction demonstrated, in meantime,...
Abstract Hypoxic postconditioning (HPC) is an innovative neuroprotective strategy with cytoprotective effects on the hippocampal neurons against transient global cerebral ischemia (tGCI) in adult rats. However, its molecular mechanisms have not yet been adequately elucidated. Neuroglobin (Ngb) endogenous neuroprotectant hypoxia-inducible property, and role experimental stroke has increasingly attractive. Hence, purpose of this study to explore involvement Ngb HPC-mediated neuroprotection...
Genome size is determined during evolution, but it can also be altered by genetic engineering in laboratories. The systematic characterization of reduced genomes provides valuable insights into the cellular properties that are quantitatively described global parameters related to dynamics growth and mutation. In present study, we analyzed a small collection W3110 Escherichia coli derivatives containing either wild-type genome or various lengths examine whether mutation rate, parameter...
Abstract Myoclonus‐dystonia (M‐D) is characterized by early‐onset myoclonus and dystonia, often due to mutations in the epsilon‐sarcoglycan gene (SCGE) at locus 7q21. The pathogenesis of M‐D poorly understood, a murine knockout model, dopaminergic hyperactivity has been postulated as mechanism. We present two unrelated individuals with SCGE deletions who displayed robust sustained response levodopa ( L ‐dopa) treatment. In contrast using dopamine blocking agents suggested hyperdopaminergic...
We previously reported that hypoxic postconditioning (HPC) ameliorated hippocampal neuronal death induced by transient global cerebral ischemia (tGCI) in adult rats. However, the mechanism of HPC-induced neuroprotection is still elusive. Notably, heat shock protein 27 (Hsp27) has recently emerged as a potent neuroprotectant ischemia. Although its robust protective effect on stroke been recognized, Hsp27-mediated largely unknown. Here, we investigated potential molecular which HPC modulates...
To explore the phenotype spectrum of DEPDC5 variants and possible mechanisms underlying phenotypical variation, we performed targeted next-generation sequencing in 305 patients with focal epilepsies 91 generalized epilepsies. Protein modeling was to predict effects missense mutations. All previously reported epilepsy-related were reviewed. The genotype-phenotype correlations molecular sub-regional implications analyzed. We identified a homozygous mutation (p.Pro1031His) case cortical...
Abstract Emerging evidence demonstrates the clinical utility of genomic applications in newborn intensive care unit (NICU) patients with strong indications Mendelian etiology. However, such applications' diagnostic yield and remain unclear for NICU cohorts minimal phenotype selection. In this study, focused medical exome sequencing was used as a first‐tier, singleton‐focused tool 2303 unrelated sick neonates. Integrated analysis single nucleotide variants (SNVs), small insertions deletions...
Metabolic syndrome (MetS) is an important risk factor for cerebral ischemic stroke, yet previous studies on the relationship between MetS or its components and acute infarction have been inconsistent. This study aims to evaluate effects of short-term prognosis patients with stroke. Subjects stroke <7-day duration (530 cases) were enrolled. was defined based modified criteria International Diabetes Federation American Heart Association/National Heart, Lung, Blood Institute. Demographic data,...
Sclerotia, the medicinal part of Polyporus umbellatus, play important roles in diuresis and renal protection, with steroids polysaccharides as main active ingredients. The sclerotia grow develop only after symbiosis Armillaria sp. In this study, a systematic metabolomics based on non-targeted UPLC-MS method was carried out between infected separated cavity wall (QR) uninfected (the control group, CK) to find identify differential metabolites. biosynthetic pathway characteristic P. umbellatus...