A5057839038- Antibiotic Resistance in Bacteria
- Pharmaceutical and Antibiotic Environmental Impacts
- Vibrio bacteria research studies
- Catalysis and Oxidation Reactions
- Catalytic Processes in Materials Science
- Asymmetric Synthesis and Catalysis
- Plant Genetic and Mutation Studies
- Drug Transport and Resistance Mechanisms
- Gut microbiota and health
- Corrosion Behavior and Inhibition
- Hydrogen embrittlement and corrosion behaviors in metals
- Soybean genetics and cultivation
- High-Temperature Coating Behaviors
- Bacteriophages and microbial interactions
- Nitrogen and Sulfur Effects on Brassica
- Advanced biosensing and bioanalysis techniques
- Medicinal Plant Pharmacodynamics Research
- Prion Diseases and Protein Misfolding
- Selenium in Biological Systems
- Medicinal Plant Extracts Effects
- Proteoglycans and glycosaminoglycans research
- Biochemical Acid Research Studies
- Natural product bioactivities and synthesis
- Viral gastroenteritis research and epidemiology
- Microbial Metabolic Engineering and Bioproduction
Hunan Agricultural University
2021-2024
Sinopec (China)
2021-2022
Northeast Petroleum University
2014
Affiliated Hospital of Youjiang Medical University for Nationalities
2012
Tohoku University
2008
Shanghai Normal University
2007
University of Pennsylvania
2007
Xi'an Jiaotong University
2006
Technical University of Denmark
2000-2004
Evidence of oxidative stress and the accumulation fibrillar amyloid beta proteins (Abeta) in senile plaques throughout cerebral cortex are consistent features pathology Alzheimer disease. To define a mechanistic link between these two processes, various aspects relationship lipid membrane damage amyloidogenesis were characterized by chemical physical techniques. Earlier studies this demonstrated that oxidatively damaged synthetic membranes promoted amyloidogenesis. The reported herein...
Tigecycline is a last-resort drug used to treat serious infections caused by multidrug-resistant bacteria. tet (X4) recently discovered plasmid-mediated tigecycline resistance gene that confers high-level and other tetracyclines. Since the first discovery of in 2019, it has spread rapidly worldwide, as consequence, become increasingly ineffective clinical treatment infections. In this study, we identified analyzed (X4)-positive Escherichia coli isolates from duck farms Hunan Province, China....
Allocryptopine (ALL) is an isoquinoline alkaloid extracted from Macleaya cordata(Willd). R. Br., which has been claimed to have anti-inflammatory and neuroprotection properties. However, the mechanism by ALL ameliorates inflammatory bowel disease (IBD) remains unclear. Here, we used network pharmacology quantitative proteomic approaches investigate effect of on IBD pathogenesis. Network predicted potential targets signaling pathways ALL's anti-IBD effects. As pharmacology, gene ontology (GO)...
Aeromonas hydrophila , a heterotrophic and Gram-negative bacterium, has attracted considerable attention owing to the increasing prevalence of reported infections. Colistin is last-resort antibiotic that can treat life-threatening infections caused by multidrug-resistant bacteria.
Background Gelsenicine, one of the most toxic alkaloids Gelsemium elegans Benth ( G. elegans), causes severe respiratory depression. However, its toxicity mechanisms are yet to be elucidated and no effective antidotes available. Objective This study aimed analyse characteristics gelsenicine. Methods Both acute sub-acute toxicities were evaluated. Gelsenicine distribution elimination in central nervous system (CNS) blood observed. Effective for gelsenicine poisoning screened. Results In...
The plasmid-mediated tigecycline resistance gene tet(X4) confers a high level of to tigecycline. experiment aims investigate the prevalence and characterization in Escherichia coli isolates from chicken pig farms Hunan province, China.A total six positive strains were identified 257 E. derived samples Xiangtan city (n = 2), Xiangxiang 1), Chenzhou Zhuzhou 1). presence was directly detected by PCR assay, then broth dilution method determined antimicrobial susceptibility profile...
ABSTRACT Cryptococcus neoformans is eradicated by macrophages via production of NO. Unmethylated CpG‐ODN protect mice from infection with this fungal pathogen inducing IFN‐γ. The present study was designed to elucidate the effect C. on synthesis NO alveolar macrophages. For purpose, MH‐S, an macrophage cell line, stimulated in presence A highly virulent strain thick capsule suppressed Capsular polysaccharides were not essential for suppression, because there no difference between acapsular...
We examined the effects of phosphorothioate-modified antisense oligodeoxyribonucleotides (PS-ODN) targeted to mRNA transcribed from gtfB, which encodes synthesis water-insoluble glucans in Streptococcus mutans. Treatment S. mutans with 10 muM PS-ODNs inhibited gtfB transcription, GtfB expression and glucan synthesis. The architecture biofilms formed by PS-ODNs-treated showed reduced biomass, more dispersed distribution enlarged interspaces fewer layers attached cells. PS-ODN treatment had no...
Aeromonas hydrophila is an important zoonotic pathogen responsible for septicemia, diarrhea and gastroenteritis, has attracted considerable attention. The EnvZ/OmpR two-component system (TCS) mediates environmental stress responses in gram-negative bacteria. We investigated the role of TCS A. by comparing characteristics parental (23-C-23), knockout (23-C-23:ΔEnvZ/OmpR), complemented strains (23-C-23:CΔEnvZ/OmpR). Under non-stress conditions, 23-C-23:ΔEnvZ/OmpR strain showed a significant...
Naja atra is a venomous snake species medically relevant in China. In the current study, we evaluated composition and toxicological profile of venom collected from farm-raised N. atra.Venom was third-generation captive bred on farm Hunan Province, The analyzed using sodium dodecyl sulfate polyacrylamide gel electrophoresis nano-liquid chromatography with electrospray ionization tandem mass spectrometry. addition, hemolytic activity, median lethal dose, serum biochemical histopathological...
Multi-drug resistance of bacteria producing extended-spectrum β-lactamase (ESBL) is a public health challenge. Thus, this study aimed to investigate the antimicrobial susceptibility ESBL-producing Escherichia coli (ESBL-EC) in Hunan Province, China. A total 1366 fecal samples were collected from pig, chicken, and cattle farms over six-year period, which assessed using strain isolation, 16S rRNA identification, polymerase chain reaction, drug sensitivity testing, whole-genome sequencing,...
2-Substituted 3-acetoxy-1-acetyl-1H-indoles were prepared by condensing 2-chlorobenzoic acids with amino under Ullmann conditions in good yields, and further cyclodecarboxylation using the Rössing method moderate to yields.
A novel cashew-based gemini surfactant was synthesized from cashew phenol, 1, 3-dibromopropane and chlorosulfonic acid through etherification, sulfonation neutralization. The critical micelle concentration (cmc) for 6.2×10 -2 mmol·L -1 , the surface tension (γ cmc ) 36.92 mN.m . Foam properties emulsification were investigated including affection of inorganic salts sodium hydroxide. oil / water interfacial can be decreased efficiently to 10 -3 mN m.
Abstract Docosahexaenoic acid (DHA) and selenium (Se) are nutrients that confer several health benefits to both humans animals. Widespread use of DHA in milk powder products requires large-scale mass production via Schizochytrium sp., while Se intended for human consumption is produced as organic yeast. However, producing these on an industrial scale constrained by various factors. We found supplementing sp. with Na 2 SeO 3 (0.5 mg/L) improves its biomass also provides Se. De novo assembled...