A5025132856- Cancer Treatment and Pharmacology
- Colorectal Cancer Treatments and Studies
- Neutropenia and Cancer Infections
- Pharmacy and Medical Practices
- Pain Mechanisms and Treatments
- Gastric Cancer Management and Outcomes
- Nausea and vomiting management
- Chemotherapy-induced organ toxicity mitigation
- Chemotherapy-related skin toxicity
- Fungal Infections and Studies
- Respiratory viral infections research
- Chronic Lymphocytic Leukemia Research
- Medication Adherence and Compliance
- Ion Channels and Receptors
- Cancer Diagnosis and Treatment
- Anesthesia and Pain Management
- Pneumocystis jirovecii pneumonia detection and treatment
- Pneumonia and Respiratory Infections
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Treatments and Mutations
- Pancreatic and Hepatic Oncology Research
- Parasitic Infections and Diagnostics
- Drug-Induced Adverse Reactions
- Pharmaceutical Practices and Patient Outcomes
- T-cell and B-cell Immunology
Japanese Foundation For Cancer Research
2016-2025
Osaka University
2010-2025
The Cancer Institute Hospital
2009-2023
Tohoku University
2008-2021
Showa Pharmaceutical University
2006-2012
Keio University
2011
Cancer Institute (WIA)
2010
Koto Hospital
2009
Tohoku University Hospital
2008
University of the Ryukyus
1994-2004
Peripheral neuropathy is a common adverse effect of paclitaxel treatment. To analyze the contribution transient receptor potential vanilloid 1 (TRPV1) in development paclitaxel-induced thermal hyperalgesia, TRPV1 expression rat dorsal root ganglion (DRG) was analyzed after Behavioral assessment using tail-flick test showed that intraperitoneal administration 2 and 4 mg/kg induced hyperalgesia days 7, 14, 21. Paclitaxel-induced day 14 significantly inhibited by TRP antagonist ruthenium red (3...
Summary Diabetes mellitus is an important predisposing factor for tuberculosis. The aim of this study was to investigate the mechanism underlying association using a murine model. Mice with streptozotocin-induced diabetes were prone Mycobacterium tuberculosis infection, as indicated by increased numbers live bacteria in lung, liver and spleen. In diabetic mice, levels IL-12 IFN-γ spleen lower than those control animals on day 14 postinfection, while opposite true IL-4 lung liver. expression...
Peripheral cold neuropathic pain is a serious side effect of oxaliplatin treatment. However, the mechanism oxaliplatin-induced hyperalgesia unknown. In present study, we investigated effects on transient receptor potential ankyrin 1 (TRPA1) in dorsal root ganglion (DRG) neurons rats.Behavioral assessment using acetone spray test showed that 3 and 6 mg/kg (i.p.) induced acute hypersensitivity after 1, 2, 4, 7 days. Real-time PCR (6 mg/kg) significantly increased TRPA1 mRNA expression DRGs at...
403 Background: The combination of docetaxel + S-1 (DS) therapy in postoperative adjuvant treatment for gastric cancer has proven to be effective and become a standard therapy. Clarification factors involved the timing non-adherence is important minimize non-adherence. Methods: Among 92 patients who started DS as chemotherapy between November 1, 2015 April 30, 2021 at Cancer Institute Hospital Japanese Foundation Research, 90 were eligible this study. adherence rate per cycle was defined...
Background: Many studies have identified risk factors for neutropenia associated with various chemotherapies, including gemcitabine plus nab-paclitaxel (GnP). However, few focused on the delayed recovery from neutropenia, which frequently leads to treatment discontinuation. We aimed examine whether affect following development. Material and Methods: Data were collected patients pancreatic cancer who received GnP therapy between December 2014 March 2019 at Cancer Institute Hospital of...
Introduction: Age has been reported as a risk factor for chemotherapy-induced nausea and vomiting. However, few reports have described factors vomiting with carboplatin (CBDCA). This study investigated whether the incidence of CBDCA-induced differs age, using 70 years cutoff. Methods: Patients who underwent CBDCA lung cancer at Cancer Institute Hospital Japanese Foundation Research between November 2020 October 2023 were included in this retrospective study. The age cut-off was set years,...
Although annexin A1 (ANXA1) is known to mediate inflammatory responses through N-formyl peptide receptor 2 (FPR2), the role of ANXA1-FPR2 signaling pathway in periodontal disease remains unclear. This study investigated contribution this pathophysiology disease. Using a ligature-induced mouse model, we performed histologic analyses examine ANXA1 and FPR2 expression. We observed upregulation within gingiva ligament. In vitro analysis human ligament cells revealed that interleukin 1β...
No established supportive therapy to prevent and treat chemotherapy-induced peripheral neuropathy (PN) is available. Minimizing the severity of PN therefore critical in clinical use. We aimed determine when how often occurs association with paclitaxel plus carboplatin (PC therapy), a regimen used non-small cell lung cancer, factors that exacerbate this condition. Patients who received PC for cancer at Japanese Foundation Cancer Research, Institute Hospital, between May 20, 2009, November 30,...
Painful peripheral neuropathy is a common adverse effect of paclitaxel (PTX) treatment. To analyze the contribution transient receptor potential vanilloid 1 (TRPV1) in development PTX-induced mechanical allodynia/hyperalgesia and thermal hyperalgesia, TRPV1 expression rat spinal cord was analyzed after intraperitoneal administration 2 4 mg/kg PTX. PTX treatment increased protein cord. Immunohistochemistry showed that (4 mg/kg) superficial layers dorsal horn 14 days Behavioral assessment...
Early detection and management of adverse drug reactions (ADRs) is crucial for improving patients’ quality life. Hand-foot syndrome (HFS) one the most problematic ADRs cancer patients. Recently, an increasing number patients post their daily experiences to internet community, example in blogs, where potential ADR signals not captured through routine clinic visits can be described. Therefore, this study aimed identify with ADRs, focusing on HFS, from blogs by using natural language processing...
SUMMARY Bleomycin (BLM), an antitumour drug, is known to cause interstitial pneumonia followed by pulmonary fibrosis, and has often been used produce animal model of fibrosis. In the present study, we examined effect a nonapeptide thymic hormone, facteur thymique serique (FTS), on murine lung fibrosis induced intratracheal instillation BLM. Treatment with FTS ameliorated BLM-induced fibrotic changes in dose-dependent manner, as indicated reduced accumulation hydroxyproline (HP). addition,...
Oxaliplatin is a chemotherapeutic agent that effective against various types of cancer including colorectal cancer. Acute cold hyperalgesia serious side effect oxaliplatin treatment. Although the therapeutic drug pregabalin beneficial for preventing peripheral neuropathic pain by targeting voltage-dependent calcium channel α2δ-1 (Cavα2δ-1) subunit, oxaliplatin-induced acute hypersensitivity uncertain. To analyze contribution Cavα2δ-1 subunit to development hypersensitivity, expression in rat...
Capecitabine plus oxaliplatin (XELOX) has been established as a first-line treatment for metastatic colorectal cancer. Adherence is particularly important with capecitabine to maintain appropriate curative effect. In this study, we monitored the adherence on XELOX and investigated which factors might decrease compliance.The study included 242 consecutive patients who received cancer between October 2009 March 2012. was checked by pharmacists patient-reported diary at pharmaceutical...
Hand-foot skin reaction (HFSR) can deteriorate quality of life in patients receiving regorafenib. Cutaneous toxicity is a main adverse effect multikinase inhibitors and has also been associated with clinical outcome. This study assessed the association between antitumor efficacy regorafenib HFSR metastatic colorectal cancer (mCRC).Patients who received at 160 mg/day during first 3 weeks each 4-week cycle were divided into subgroups based on whether they developed May 2013 October 2015....
Trastuzumab deruxtecan (T-DXd) has displayed demonstrable efficacy and manageable toxicity in previously treated patients with advanced gastric breast cancer, it been approved Japan. However, there is a lack of data on the optimal management clinical practice. Therefore, we assessed adverse event (AE) profiles T-DXd or cancer to provide guidance for appropriate management. This retrospective study was conducted at Cancer Institute Hospital Japanese Foundation Research. We reviewed medical...
Amphotericin B (AmB) is a classical antifungal drug and one of the most effective drugs for treatment systemic fungal infection. It also known to have various immunomodulating activities other than its direct effect. In present study, we demonstrated that AmB augmented gamma interferon (IFN-gamma)-induced killing potentials murine peritoneal macrophages against Cryptococcus neoformans in dose-dependent manner. This effect was strongly blocked by NG-monomethyl-L-arginine, competitive...
XELOX (capecitabine plus oxaliplatin) is a standard treatment for unresectable advanced colorectal cancer. Combining oral and intravenous administration, it convenient method of but full patient compliance regarding capecitabine necessary to obtain efficacy. To help ensure good this drug, we established pharmaceutical outpatient clinic at the Cancer Institute Hospital Japanese Foundation Research (JFCR) where pharmacists interview patients prior physicians' assessments. Medication adverse...
<b><i>Background:</i></b> A novel oral agent that consists of trifluridine and tipiracil hydrochloride (TFTD) has been established as salvage-line treatment for metastatic colorectal cancer (mCRC). Adherence to TFTD is crucial maintaining appropriate curative effects. This study sought clarify adherence identify candidate factors deteriorating at our institution. <b><i>Methods:</i></b> total 50 consecutive mCRC patients who received monotherapy...
Abstract Background Female sex and younger age are reported risk factors for chemotherapy‐induced nausea vomiting (CINV) in highly emetogenic chemotherapy, but the underlying mechanism has not been elucidated. The purpose of this study was to clarify impact menopause on CINV. Methods This retrospective observational analyzed data from consecutive patients who received their first cycle perioperative anthracycline‐based chemotherapy breast cancer between January 2018 June 2020. endpoints were...
ABSTRACT Cryptococcus neoformans is eradicated by macrophages via production of NO. Unmethylated CpG‐ODN protect mice from infection with this fungal pathogen inducing IFN‐γ. The present study was designed to elucidate the effect C. on synthesis NO alveolar macrophages. For purpose, MH‐S, an macrophage cell line, stimulated in presence A highly virulent strain thick capsule suppressed Capsular polysaccharides were not essential for suppression, because there no difference between acapsular...
Adherence has become an important issue in modern oncology treatment. Most studies have included heterogeneous target tumor types, regimens, and therapy settings. Our study focused on capecitabine during plus oxaliplatin (XELOX) treatment as adjuvant for colorectal cancer. The main aims of this were to evaluate real-life adherence investigate candidate factors that might decrease adherence. We studied 338 consecutive patients who received XELOX between December 1, 2011, April 30, 2015, at...
Abstract We investigated the susceptibility of three clinically isolated strains Cryptococcus neoformans with different virulences to reactive nitrogen and oxygen intermediates (RNI ROI, respectively), representing two important mediators macrophage microbicidal activity. All mice infected highly virulent strain C. , YC‐11, died within 3 6 weeks because rapid multiplication organism in lungs dissemination brain. In contrast, a weakly strain, YC‐13, was almost completely eradicated from did...