The effect of isomalto-oligosaccharides on human fecal flora was studied. Bifidobacteria and the Bacteroides fragilis group from intestine could utilize but Escherichia coli other bacteria not. After administration isomaltooligosaccharides (13.5 g daily for 2 weeks) to healthy adult men senile persons, numbers bifidobacteria in feces increased. consistency improved. These studies may support usefulness as components new foodstuffs improvement intestinal flora.

Abstract Background Coronavirus infections are spreading rapidly worldwide, and primary middle schools closed in many countries. After the state of emergency was lifted Japan, have reopened, teachers conducting face-to-face classes while maintaining safety precautions. This study aimed to assess factors contributing infection-related anxiety educational among during COVID-19 pandemic after reopened. Methods questionnaire-based cross-sectional conducted with 263 school Shinagawa area Tokyo...

Aquaporin-3 (AQP3) is a water channel that predominantly expressed in the colon, where it plays critical role regulation of fecal content. This study investigated AQP3 colon morphine-induced constipation. expression levels were analyzed after oral morphine administration to rats. The degree constipation was combined HgCl(2) (AQP3 inhibitor) or fluoxetine (5-HT reuptake transporter [SERT] and morphine. mechanism by which increased examined HT-29 cells. rat during combination improved...

The average age of patients with type 2 diabetes in Japan is over 70 years. Elderly tend to have poor medication compliance, therefore, it important understand their individual situations improve the treatment diabetes, and quality life (QOL). This study aimed identify factors associated compliance elderly diabetic patients. A cross-sectional based on questionnaires was conducted aged 65 years or older. participants were recruited from who visited three dispensing pharmacies Shinagawa area...

The bioadhesion property of tablets consisting chitosan (CS) and sodium hyaluronate (HA) was investigated using a lyophilized porcine dermis as model mucous membrane. Release phenomena brilliant blue FCF (BBL) from the CS-HA were also studied. BBL employed compound water-soluble drugs. Strong adhesion forces observed when prepared HA alone or physical mixture CS HA. obtained but it rather weak. No effect pH values in media on force these tablets. On other hand, release rate greatly affected...

The COVID-19 pandemic increased psychological stress and decreased sleep quality, especially among young people. Aromatherapy alleviates stress, bergamot essential oil helps improve depression. This study aimed to verify whether use due the improves quality morning wakefulness.A placebo-controlled, randomized, open-label, two-arm, two-period crossover trial.Each intervention period was 1 week, with a 1-week washout between two periods. Participants used or placebo spray before bedtime upon...

Irinotecan-containing nanoparticles (NP) were prepared by coprecipitation with addition of water to acetone solution poly(DL-lactic acid), poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) and irinotecan, subsequent evaporation organic solvent. NP purified gel filtration used for experiments after condensation evaporation. The obtained showed the drug content 4.5% (w/w) mean particle diameter 118 nm distribution between 80-210 nm. When antitumor effect was...

While irinotecan (CPT-11) has a potent anti-cancer effect, it also causes serious diarrhea as an adverse reaction. In this study, we analyzed the pathogenic mechanism of CPT-11-induced delayed by focusing on water channel aquaporin-3 (AQP3) in colon. When rats received CPT-11, expression level AQP3 was reduced during severe diarrhea. It found that levels inflammatory cytokines and loss crypt cells were increased colon when CPT-11 administered. celecoxib, anti-inflammatory drug, concomitantly...

Abstract Background The method of displaying nutrition information labels on the front food packaging (FOP: Front Pack) has been implemented worldwide to prevent lifestyle-related diseases. This study aimed investigate whether use UK’s Traffic Light Food (TLF) label, known as FOP influences dietary choices Japanese youth and promotes healthy choices. Methods Diet selection was performed for one week each during baseline intervention periods. During period, TLF were displayed meal images...

Capecitabine plus oxaliplatin (XELOX) has been established as a first-line treatment for metastatic colorectal cancer. Adherence is particularly important with capecitabine to maintain appropriate curative effect. In this study, we monitored the adherence on XELOX and investigated which factors might decrease compliance.The study included 242 consecutive patients who received cancer between October 2009 March 2012. was checked by pharmacists patient-reported diary at pharmaceutical...

<b><i>Background:</i></b> A novel oral agent that consists of trifluridine and tipiracil hydrochloride (TFTD) has been established as salvage-line treatment for metastatic colorectal cancer (mCRC). Adherence to TFTD is crucial maintaining appropriate curative effects. This study sought clarify adherence identify candidate factors deteriorating at our institution. <b><i>Methods:</i></b> total 50 consecutive mCRC patients who received monotherapy...

A cream that contains menthol and diphenhydramine is widely prepared in hospital pharmacies prescribed to patients for the treatment of pruritus associated with chronic kidney disease. However, there a serious concern regarding its physical stability; therefore, we investigated this issue using magnetic resonance imaging (MRI). For sample preparation, menthol-containing ethanol solution was mixed commercial cream. After storage 7 d at 40°C, substantial phase separation into two distinct...

Aquaporin-3 (AQP3) plays an important role in maintaining the normal water content of skin. Previously, we revealed that expression cutaneous AQP3 increased following oral administration Gypsum fibrosum (main component: CaSO₄) to mice. The purpose this study is elucidate mechanism by which increases a keratinocyte cell line. or CaSO₄ was added keratinocytes, and level AQP3, Ca concentration, activity protein kinase C (PKC), degrees phosphorylation both extracellular signal-regulated (ERK)...

The expression levels of cytochrome P450 (CYP) in the liver were analyzed over time dextran sulfate sodium (DSS)-induced ulcerative colitis mouse model, from initial active stage to remission stage, investigate relationship between changes pathological conditions and CYP levels.DSS solution was given mice for 10 days, after which water without DSS provided 40 days. Pathological examined time. mechanism variation also analyzed.The mRNA (CYP3A11, CYP1A2, CYP2C29, CYP2D9, CYP2E1) decreased as...

Adherence has become an important issue in modern oncology treatment. Most studies have included heterogeneous target tumor types, regimens, and therapy settings. Our study focused on capecitabine during plus oxaliplatin (XELOX) treatment as adjuvant for colorectal cancer. The main aims of this were to evaluate real-life adherence investigate candidate factors that might decrease adherence. We studied 338 consecutive patients who received XELOX between December 1, 2011, April 30, 2015, at...

Glucose-6-phosphate dehydrogenase was partially purified starting from the cell-free extract of Lactobacillus plantarum 11 and properties were investigated. The intracellular activity enzyme calculated. Using kinetic data concerning in presence various concentrations coenzyme, inorganic ions, this under conditions thought to be comparable with an intracytoplasmic environment calculated 0.04μ moles per mg dry weight cells hr. This value 1% lactic acid forming intact cells. A similar...

Mizushima, Shôji (University of Tokyo, Japan), Yoshiaki Machida, and Kakuo Kitahara . Quantitative studies on glycolytic enzymes in Lactobacillus plantarum I. Concentration inorganic ions coenzymes fermenting cells. J. Bacteriol. 86: 1295–1300. 1963.—An attempt was made to summarize the intracellular conditions which a lactic acid fermentation proceeded at steady state. The structure cell studied by fractionating constituents measuring volume each constituent inulin space method. pH value...