A5002221547- Gastric Cancer Management and Outcomes
- Chemical Synthesis and Reactions
- Organic Chemistry Cycloaddition Reactions
- Colorectal Cancer Surgical Treatments
- Oxidative Organic Chemistry Reactions
- Insect-Plant Interactions and Control
- Colorectal Cancer Treatments and Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Insect behavior and control techniques
- Enhanced Recovery After Surgery
- Synthesis and Catalytic Reactions
- Genetic factors in colorectal cancer
- Esophageal Cancer Research and Treatment
- Cancer-related molecular mechanisms research
- Fibroblast Growth Factor Research
- Cancer Diagnosis and Treatment
- T-cell and B-cell Immunology
- Chemokine receptors and signaling
- Nutrition and Health in Aging
- Robotics and Automated Systems
- Microbial metabolism and enzyme function
- Immune Response and Inflammation
- Cardiac, Anesthesia and Surgical Outcomes
- Colorectal and Anal Carcinomas
- Pancreatic and Hepatic Oncology Research
Osaka Metropolitan University
2022-2025
Osaka University
2017-2025
Mitsui Memorial Hospital
2025
Center for Digestive and Liver Diseases
2025
Columbia University
2025
Chuo University
2022-2024
Mitsubishi Gas Chemical (Japan)
2020-2023
Tokyo Metropolitan University
2023
Osaka City University
2018-2022
Baba Memorial Hospital
2022
Abstract Hepatic stellate cells (HSCs) have a central pathogenetic role in the development of liver fibrosis. However, their fibrosis-independent and homeostatic functions remain poorly understood 1–5 . Here we demonstrate that genetic depletion HSCs changes WNT activity zonation hepatocytes, leading to marked alterations regeneration, cytochrome P450 metabolism injury. We identify R-spondin 3 (RSPO3), an HSC-enriched modulator signalling, as responsible for these hepatocyte-regulatory...
CDK8/19 inhibitors can convert naïve and memory/effector T cells into reg capable of treating immunological diseases.
Foxp3-expressing regulatory T cells (Tregs) can be generated in vitro by antigenic stimulation of conventional (Tconvs) the presence TGF-β and IL-2. However, unlike Foxp3 + naturally occurring Tregs, such induced Tregs (iTregs) are functionally unstable mainly because incomplete Treg-type epigenetic changes at Treg signature genes as . Here we show that deprivation CD28 costimulatory signal an early stage iTreg generation is able to establish Treg-specific DNA hypomethylation genes. It was...
We have previously reported that chemokine (C-X-C motif) receptor 2 (CXCR2) signaling was associated with the malignant progression of gastric cancer (GC). thus examined clinicopathological significance CXCR2 ligands, CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL7, and CXCL8, in GC.The expression ligands 590 GC cases investigated by immunohistochemistry.The as follows: 46.2% (257/557); 20.7% (122/590); 17.1% (101/589); CXCL5/CXCL6, 2.9% (17/589); 36.4% (215/590); CXCL8 1.7% (10/585) cases. High...
Systemic inflammation is recognized as a hallmark of cancer that contributes to tumor development and progression in various malignancies. The Naples prognostic score (NPS) was established indicator for colorectal (CRC). This study aims examine the predictive value NPS survival CRC patients undergoing curative resection by propensity matching (PSM) analysis.A total 533 were enrolled this study. Overall (OS) disease-free (DFS) compared between high-NPS low-NPS groups. A time-dependent...
To evaluate the impact of prior teriparatide (TPTD) treatment on effectiveness romosozumab (ROMO) in postmenopausal osteoporosis.
Reduction in skeletal muscle mass during chemotherapy is associated with poor outcomes. This study investigated the impact of changes psoas index (PMI) on prognosis patients unresectable colorectal liver metastases (CRLM) undergoing chemotherapy, including subgroup analyses based initial treatment response assessment.
Estrogen deficiency following menopause increases receptor activator of nuclear factor-kappa B ligand (RANKL) expression in osteoblasts, thereby promoting osteoclast differentiation, and enhances T cell-derived tumor necrosis factor-alpha (TNFα) production, which induces sclerostin osteocytes, inhibiting bone formation. This study aimed to develop a novel uncoupling therapeutic agent for osteoporosis. We developed microglial healing peptide 1 with N-terminal acetylation C-terminal amidation...
Although annexin A1 (ANXA1) is known to mediate inflammatory responses through N-formyl peptide receptor 2 (FPR2), the role of ANXA1-FPR2 signaling pathway in periodontal disease remains unclear. This study investigated contribution this pathophysiology disease. Using a ligature-induced mouse model, we performed histologic analyses examine ANXA1 and FPR2 expression. We observed upregulation within gingiva ligament. In vitro analysis human ligament cells revealed that interleukin 1β...
Antigen-specific oral tolerance is effective in preventing harmful immune responses antigen-non- sensitized animals but difficult to induce those already antigen-primed. Here, we show mice that feeding of antigen-containing diet generates mesenteric lymph nodes and intestinal lamina propria peripherally derived regulatory T (pTreg) cells exhibit a terminally differentiated effector phenotype as seen with tissue-resident thymus-derived Treg (tTreg) cells. Antigen also enables the generated...
The widely used sodium channel blocker tetrodotoxin (TTX) is a compound that has six hydroxyl residues at the C-4, C-6, C-8, C-9, C-10, and C-11 positions in addition to guanidinium group, which positively charged biological pH range. Thirteen analogs of this toxin with structural modifications involving one or more these hydroxyls were examined on their affinity rat brain membrane preparation, known contain channels abundantly. equilibrium dissociation constants associated binding TTX its...
Abstract Apples are well known to have various benefits for the human body. Procyanidins a class of polyphenols found in apples that demonstrated effects on circulatory system and skeletal organs. Osteoarthritis (OA) is locomotive syndrome histologically characterized by cartilage degeneration associated with impairment proteoglycan homeostasis chondrocytes. However, no useful therapy has been developed date. In present study, we detected beneficial apple or their procyanidins homeostasis....
Pyrroloquinoline quinone (PQQ) is contained in fruits and vegetables human breast milk. It has been reported that PQQ high reactivity changes to an imidazole structure (imidazole pyrroloquinoline) by a reaction with amino acid at ratio nature. A comparative study was conducted clarify physiological effects including neuroprotective effects, growth-promoting effect, antioxidative stimulatory effect on mitochondriogensis of pyrroloquinoline (IPQ) using neuroblastoma cell line hepatocellular...
Introduction Thrombospondin-4 [1] is an extracellular glycoprotein involved in wound healing and tissue remodeling. Although THBS4 reportedly frequently expressed solid tumors, there are few reports of the clinicopathological features carcinomas with expression. We evaluated clinicopathologic significance expression gastric carcinoma (GC). Materials methods retrospectively analyzed cases 584 GC patients. The each tumor was by immunohistochemistry. then divided patients into THBS4-high (n =...
Abstract Background Postoperative anastomotic leakage (AL) is associated with not only prolonged hospital stay and increased medical costs, but also poor prognosis in esophageal cancer. Several studies have addressed the utility of various inflammation-based and/or nutritional markers as predictors for postoperative complications. However, none been documented specific AL We aimed to identify after esophagectomy thoracic cancer, focusing on preoperative markers. Methods retrospectively...
Because of the scanty pipeline antibiotics newly obtained from nature, chemical modification established drugs is one major streams current antibacterial research. Intuitive and easy-to-use assays are critical for identifying drug candidates with novel modes action. In this study, we demonstrated that metabolic fluorescent staining growing cell walls a powerful tool mode-of-action analyses using Streptococcus pyogenes. A set cell-wall-inhibiting (bacitracin, D-cycloserine, flavomycin,...
Cancer stem cells (CSCs) play an important role in the progression of carcinoma and have a high potential for survival stress environments. However, mechanisms CSCs been unclear. The aim this study was to clarify significance autophagy systems under Four gastric cancer cell line were used. Side population (SP) sorted from parent cells, as CSC rich cells. expression markers examined by RT-PCR. viability starvation hypoxia evaluated. level molecule LC3B-II western blot. numbers autophagosomes...
The purpose of this study was to investigate whether a three-direction accelerometer is useful for measuring daily physical activity. Physical activity, being an important part human behavior, may be related various aspects health and disease. In study, the relationship between intensity each action (Actigraph) output compared in 10 healthy subjects under free-living conditions. Subjects wore Actigraph on their non-dominant wrist filled out activity check list (self-report) throughout...
Abstract Fibroblast growth factor receptor 2 (FGFR2) has two isoforms: IIIb type and IIIc type. Clinicopathologic significance of these FGFR2 subtypes in gastric cancer remains to be known. This study aimed clarify the clinicopathologic difference FGFR2IIIb and/or FGFR2IIIc overexpression. A total 562 patients who underwent gastrectomy was enrolled. The expressions were retrospectively examined by immunohistochemistry or fluorescence situ hybridization (FISH) using tumors. We evaluated...