A5060031431- Bone Metabolism and Diseases
- Foot and Ankle Surgery
- Bone health and osteoporosis research
- Tendon Structure and Treatment
- Bone health and treatments
- Osteoarthritis Treatment and Mechanisms
- Cytokine Signaling Pathways and Interactions
- Rheumatoid Arthritis Research and Therapies
- Bone and Joint Diseases
- Lower Extremity Biomechanics and Pathologies
- Musculoskeletal synovial abnormalities and treatments
- Knee injuries and reconstruction techniques
- Streptococcal Infections and Treatments
- Periodontal Regeneration and Treatments
- Infectious Diseases and Tuberculosis
- Orthopaedic implants and arthroplasty
- NF-κB Signaling Pathways
- Toxin Mechanisms and Immunotoxins
- Mesenchymal stem cell research
- Autoimmune and Inflammatory Disorders Research
- Colorectal Cancer Treatments and Studies
- Orthopedic Infections and Treatments
- Dupuytren's Contracture and Treatments
- Alkaline Phosphatase Research Studies
- TGF-β signaling in diseases
Osaka Rosai Hospital
2024-2025
Osaka University
2020-2023
Japan Community Healthcare Organization
2018-2019
Osaka Hospital
2018-2019
Distal tibial oblique osteotomy (DTOO) has traditionally been contraindicated in patients with rheumatoid arthritis (RA). However, advances RA treatment, an increasing number of present resembling osteoarthritis (OA), suggesting DTOO as a potential option. This study aimed to compare mid-term clinical and radiographic outcomes between the OA RA. included 8 ankles 7 (Stage IIIa-IIIb, Takakura-Tanaka classification) 5 (equivalent Stage IIIa). Clinical (JSSF ankle/hindfoot scale, SAFE-Q),...
Estrogen deficiency following menopause increases receptor activator of nuclear factor-kappa B ligand (RANKL) expression in osteoblasts, thereby promoting osteoclast differentiation, and enhances T cell-derived tumor necrosis factor-alpha (TNFα) production, which induces sclerostin osteocytes, inhibiting bone formation. This study aimed to develop a novel uncoupling therapeutic agent for osteoporosis. We developed microglial healing peptide 1 with N-terminal acetylation C-terminal amidation...
Objectives: To evaluate the effectiveness of add-on iguratimod (IGU) in patients with rheumatoid arthritis (RA) who showed an inadequate response to tocilizumab (TCZ), especially were intolerant effective dose methotrexate (MTX). Methods: Thirty-one RA (22 women, age 62.4 years, disease duration 13.8 prior TCZ 35.7 months, 25 intravenous [8 mg/kg/4 weeks] and 6 subcutaneous [162 mg/2 treatments, concomitant MTX 8.5 mg/week [35.5%], prednisolone (PSL) 4.3 mg/day [25.8%]) (disease activity...
Synovial mesenchymal stem cell (SMSC) is the promising source of cartilage regeneration but has several issues to overcome such as limited proliferation and heterogeneity ability. Previous reports demonstrated that basic fibroblast growth factor (bFGF) can promote differentiation potential MSCs in vitro, although no show its beneficial effect vivo. The purpose this study investigate promoting bFGF on using human SMSC SMSCs were cultured with or without a medium, 2 × 105 cells aggregated form...
ABSTRACT This report describes the arthroscopic treatment of septic arthritis ankle joint in two patients with inflammatory diseases, including rheumatoid and nail psoriasis. We treated both joints antibiotic administration urgent synovectomy irrigation, although procedure was performed several days (4 6 days) after time at which infection would have occurred. Fortunately, no recurrence has been seen for >18 20 months, respectively, surgery, without administration. Although accounts a...
NF-κB is a transcription factor that activated with aging. It plays key role in the development of osteoporosis by promoting osteoclast differentiation and inhibiting osteoblast differentiation. In this study, we developed small anti-NF-κB peptide called 6A-8R from nuclear acidic protein (also known as macromolecular translocation inhibitor II, Zn2+-binding protein, or parathymosin) inhibits transcriptional activity without altering its binding to DNA. Intraperitoneal injection attenuated...
Biomechanical stimulation is reportedly pivotal in meniscal regeneration, although its effect on mesenchymal stem cell (MSC) differentiation remains elusive. In this study, we investigated how cyclic compressive loading (CCL) could impact MSCs using three-dimensional cultures atelocollagen-based substitute (ACMS).
Case: Three cases of inflammatory joint diseases (systemic lupus erythematosus and ongoing juvenile idiopathic arthritis) with painful flexible progressive collapsing foot deformity (PCFD) underwent flatfoot surgery. All maintained sufficient radiological correction achieved good clinical condition at final follow-up. Conclusion: Although the prospect for recurrence is not clear, even in diseases, flat surgery such as flexor digitorum longs transfer, spring ligament reconstruction, lateral...
Objectives: To clarify the effect of combining medial capsule interposition with modified scarf osteotomy for hallux valgus.Methods: A multicenter, retrospective study included 64 cases [59 osteoarthritis patients (excluding rheumatoid arthritis); age 68.8 years, range 40-93 years] which were performed from 2013 to 2017 and followed 26.6 (range, 13-50) months. Patients treated by either (1) without (33 cases) or (2) combined (31 at each senior surgeon's discretion. The Japanese Society...
ABSTRACT This study evaluated a reverse V-shaped osteotomy for ankylosing rocker-bottom foot deformity in patients with rheumatoid arthritis. Three feet were presented this study: deformities painful and/or infectious bony prominence towards the bottom of foot, treated mid-hindfoot. In all three cases, significant correction was achieved restoration medial longitudinal arch, and improvement clinical scores confirmed. Reverse has potential to be useful definitive procedure
Abstract Of the three ankles after total ankle arthroplasty (TAA) with medial malleolar osteotomy for severe varus deformity (talar tilt >10°), two failed in migration of tibial component. In these cases, was performed alignment 5°and 2°, and medially shifted placement component, while one showed no migratoin prostheses 5 years, even nonunion. this case, a valgus 4°. Internal fixation should be done cases. Medially component avoided. Fortunately, failure did not occur case distal...