A5087119700- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Knee injuries and reconstruction techniques
- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Orthopedic Infections and Treatments
- Psoriasis: Treatment and Pathogenesis
- Bone and Joint Diseases
- Shoulder Injury and Treatment
- Autoimmune and Inflammatory Disorders Research
- Osteoarthritis Treatment and Mechanisms
- Lower Extremity Biomechanics and Pathologies
- Bone Metabolism and Diseases
- NF-κB Signaling Pathways
- Monoclonal and Polyclonal Antibodies Research
- Foot and Ankle Surgery
- Bone health and treatments
- Musculoskeletal synovial abnormalities and treatments
- Orthopedic Surgery and Rehabilitation
- Cytokine Signaling Pathways and Interactions
- Systemic Lupus Erythematosus Research
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- T-cell and B-cell Immunology
- Diabetic Foot Ulcer Assessment and Management
Osaka University
2016-2025
Morinomiya University of Medical Sciences
2022-2025
University of Tsukuba
2024
University of Tsukuba Hospital
2024
The University of Tokyo
2023-2024
Saitama Institute of Technology
2023-2024
Osaka University of Health and Sport Sciences
2024
Saitama Medical University
2024
Osaka University Hospital
2007-2023
Social Insurance Saitama Chuo Hospital
2023
Abstract Calcium hydroxyapatite ceramics (CHA) are nontoxic materials, provoke little reaction from tissues, and by virtue of these properties represent a good starting point for creating bone substitutes. Although several porous CHAs have been used clinically, there few reports that CHA is fully replaced newly formed bone, which may be due to its structure the limited connectivity between pores. We recently developed interconnected (IP‐CHA) adopting “foam‐gel” technique. Structural analysis...
Axial spondyloarthritis (axSpA) is a complex disease with diverse manifestations, for which new treatment options are warranted. BE MOBILE 1 (non-radiographic (nr)-axSpA) and 2 (radiographic axSpA (r-axSpA)) double-blind, phase 3 trials designed to evaluate efficacy safety of bimekizumab, novel dual interleukin (IL)-17A IL-17F inhibitor, across the spectrum.In parallel 52-week trials, patients active were randomised 1:1 (nr-axSpA) or 2:1 (r-axSpA) bimekizumab 160 mg every 4 weeks:placebo....
Abstract A unique feature in inflammatory tissue of rheumatoid arthritis (RA) is the formation ectopic lymphoid aggregates with germinal center (GC)-like structures that can be considered to contribute pathogenesis RA, because local production autoantibody, factor, thought a causative factor damage. However, factors governing GC RA are presently unknown. To begin address this, expression B cell attracting chemokine (BCA-1) (CXCL13), potent chemoattractant cells, was examined synovium...
Recent clinical studies suggest that several antihypertensive drugs, especially angiotensin-converting enzyme inhibitors, reduced bone fractures. To clarify the relationship between hypertension and osteoporosis, we focused on role of angiotensin II (Ang II) metabolism. In marrow-derived mononuclear cells, Ang (1x10(-6) M) significantly increased tartrate-resistant acid phosphatase (TRAP) -positive multinuclear osteoclasts. Of importance, induced expression receptor activator NF-kappaB...
Objective In both rheumatoid arthritis and collagen-induced (CIA), the nuclear factor κB (NF-κB) transcription plays a pivotal role in coordinated transactivation of many cytokines related to pathogenesis. This study investigated whether synthetic double-stranded DNA that show high affinity for NF-κB could be introduced vivo as “decoy” cis elements bind block activation such proinflammatory cytokine genes interleukin-1 (IL-1) tumor necrosis α (TNFα), thus suppress severity joint destruction....
Two-dimensional (2-D)/three-dimensional (3-D) registration techniques using single-plane fluoroscopy are highly important for analyzing 3-D kinematics in applications such as total knee arthroplasty (TKA) implants. The accuracy of fluoroscopy-based the determination translation perpendicular to image plane (depth position), however, is relatively poor because a change depth position causes only small changes 2-D silhouette. Accuracies achieved conventional 2-D/3-D insufficient clinical...
A spherical aberration-corrected electron microscope has been developed recently, which is equipped with a 300-kV cold field emission gun and an objective lens of small chromatic aberration coefficient. dumbbell image 47 pm spacing, corresponding to pair atomic columns germanium aligned along the [114] direction, resolved in high-angle annular dark (HAADF) scanning transmission microscopy (STEM) 0.4-eV energy spread beam. The observed was compared simulated obtained by dynamical calculation.
Myelography was performed in 535 patients at the Memorial Sloan-Kettering Hospital from January 1979 to December 1979. In 110 cases a complete block demonstrated and of these, 78 had epidural metastases. A uniform treatment applied using radiation therapy high dose steroid. The neurologic outcome for each patient evaluated, correlating pre-treatment status, pathologic type, nature (level, structural versus tumoral), result repeat fluoromyelography. Only 2 improved, but 11 became completely...
Methotrexate (MTX), the anchor drug in current treatment strategy for rheumatoid arthritis (RA), was first approved of RA Japan 1999 at recommended dose 6-8 mg/week; it as first-line with maximum 16 mg/week February 2011. However, more than half Japanese patients are unable to tolerate a MTX. Moreover, some serious adverse events during MTX, such pneumocystis pneumonia (PCP) and lymphoproliferative disorders (LPD) have been observed much frequently other countries. Therefore, this article,...
Objectives To investigate the efficacy and safety of ixekizumab for up to 52 weeks in two phase 3 studies patients with active radiographic axial spondyloarthritis (r-axSpA) who were biological disease-modifying antirheumatic drug (bDMARD)-naive (COAST-V) or tumour necrosis factor inhibitor (TNFi)-experienced (COAST-W). Methods Adults r-axSpA randomised 1:1:1:1 (n=341) 80 mg every 2 (IXE Q2W) 4 Q4W), placebo (PBO) 40 adalimumab Q2W (ADA) COAST-V 1:1:1 (n=316) IXE Q2W, Q4W PBO COAST-W. At...
Objectives Bimekizumab (BKZ), a monoclonal IgG1 antibody that selectively inhibits interleukin (IL)-17F in addition to IL-17A, has demonstrated superior efficacy versus placebo patients with non-radiographic (nr-) and radiographic (r-) axial spondyloarthritis (axSpA) at Week 16. Here, the objective is report safety of BKZ 52. Methods BE MOBILE 1 (nr-axSpA; NCT03928704 ) 2 (r-axSpA; NCT03928743 comprised 16-week, double-blind, placebo-controlled period, then 36-week maintenance period. From...
Semaphorin 4D (Sema4D)/CD100 has pleiotropic roles in immune activation, angiogenesis, bone metabolism, and neural development. We undertook this study to investigate the role of Sema4D rheumatoid arthritis (RA).Soluble (sSema4D) levels serum synovial fluid were analyzed by enzyme-linked immunosorbent assay. Cell surface expression transcripts peripheral blood cells from RA patients, immunohistochemical staining was performed synovium. Generation sSema4D evaluated an ADAMTS-4-treated...
Osteoarthritis (OA) is one of the most common joint diseases in elderly people, however, underlying mechanism OA pathogenesis not completely clear. Periostin, extracellular protein, has been shown by cDNA array analysis to be highly expressed OA, but its function fully understood. The purpose this study was examine expression and periostin human OA.Human cartilage synovia samples were used for function. obtained from knees patients undergoing total knee arthroplasty as femoral bone head with...
We previously described abnormalities in the bone marrow of patients with rheumatoid arthritis (RA), but were able to shed little light on pathogenic roles inflammatory cytokines and proteinases joint destruction subchondral region RA. This is first report describe co-localization this area.Decalcified paraffin-embedded sections from 10 RA five osteoarthritis (OA) examined for immunolocalization cathepsins B, K L localization messenger RNAs interleukin 1beta (IL-1beta), tumour necrosis...
In Asia and the Middle-East, people often flex their knees deeply in order to perform activities of daily living. The purpose this study was investigate 3D kinematics normal during high-flexion activities. Our hypothesis that femorotibial rotation, varus-valgus angle, translations, kinematic pathway activities, varied according activity.We investigated vivo eight four male volunteers (mean age 41.8 years; 37 53) using 2D registration technique, modelled with a computer aided design program....
Abstract Objectives Bimekizumab, a monoclonal IgG1 antibody that selectively inhibits interleukin (IL)‑17F in addition to IL-17A, previously demonstrated efficacy and was well tolerated 1 year patients with non-radiographic (nr-) radiographic (r-) axial spondyloarthritis (axSpA). Here, we report bimekizumab safety 2 years. Methods Patients completing week 52 the phase 3 studies BE MOBILE (nr-axSpA; NCT03928704) (r‑axSpA; NCT03928743) were eligible for an ongoing open‑label extension (OLE;...
The effect of axial rotation between the femoral neck and ankle joint (total [TR]) on normal knees is unknown. Therefore, this study aimed to investigate TR knee kinematics. Volunteers were divided into groups large (L), intermediate (I), small (S), using hierarchical cluster analysis based in standing position. was measured three-dimensional (3D) bone models generated from CT. A two-dimensional 3-dimensional registration technique used assess spatial position femur tibia orientation during...