A5085337453- Systemic Lupus Erythematosus Research
- Systemic Sclerosis and Related Diseases
- Vasculitis and related conditions
- Inflammatory Myopathies and Dermatomyositis
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- Urticaria and Related Conditions
- Rheumatoid Arthritis Research and Therapies
- Lymphoma Diagnosis and Treatment
- Microbial Metabolic Engineering and Bioproduction
- T-cell and B-cell Immunology
- Wastewater Treatment and Nitrogen Removal
- Autoimmune and Inflammatory Disorders Research
- Biofuel production and bioconversion
- Otitis Media and Relapsing Polychondritis
- Immunodeficiency and Autoimmune Disorders
- Advanced oxidation water treatment
- Eosinophilic Disorders and Syndromes
- Viral Infections and Immunology Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Metabolomics and Mass Spectrometry Studies
- Viral-associated cancers and disorders
- Chemical Synthesis and Analysis
- Atherosclerosis and Cardiovascular Diseases
Wakayama Medical University
2016-2025
Kyoto University
2012-2023
Kyoto University of Advanced Science
2018
Kyushu University
2017
Keio University
1992-2016
Ibero American University
2016
Sojo University
2000-2016
Ministry of Health Labour and Welfare
2015
The University of Tokyo
1997-2015
University hospital Medical Information Network
2015
Objectives. Various autoantibodies are detected in the sera of PM/DM patients. Some them specific to patients and closely associated with clinical manifestations diseases. Recently, anti-CADM-140 antibody was reported be found specifically clinically amyopathic DM (C-ADM) acute interstitial lung disease (ILD). We assessed significance then investigated autoantigen recognized by antibody. Methods. Autoantibodies were screened 192 various CTDs 21 healthy controls using immunoprecipitation...
Abstract Introduction We investigated the clinical and serological features of patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in Japan using data from a nationwide, prospective, inception cohort study. Methods In total, 156 Japanese newly diagnosed AAV were classified according to European Medicines Agency (EMEA) algorithm exploratory surrogate markers for AAV-related non-granulomatous pulmonary lesions, predefined as alveolar haemorrhage interstitial...
In the treatment of polymyositis and dermatomyositis (PM/DM), complication interstitial lung disease (ILD) is an important prognostic factor. It has been reported that autoantibodies against aminoacyl-tRNA synthetases (ARS) are strongly associated with ILD. The aim this study to examine correlation between anti-ARS clinical course We investigated 41 cases PM/DM response ILD corticosteroids (CS) was determined according change in respiratory symptoms, image findings, pulmonary function...
Anaerobic ammonium oxidation (anammox) and denitrification are two distinct microbial reactions relevant to the global nitrogen cycle. The proposed initial step of anammox reactions, reduction nitrite nitric oxide, has been postulated be identical that in catalyzed by dissimilatory reductase cytochrome cd 1 ‐type. Here, we characterized copper‐containing homolog encoded nirK detected genome an bacterium strain KSU‐1. We hypothesize this NirK‐type reductase, rather than a ‐type (NirS), is...
Methotrexate (MTX), the anchor drug in current treatment strategy for rheumatoid arthritis (RA), was first approved of RA Japan 1999 at recommended dose 6-8 mg/week; it as first-line with maximum 16 mg/week February 2011. However, more than half Japanese patients are unable to tolerate a MTX. Moreover, some serious adverse events during MTX, such pneumocystis pneumonia (PCP) and lymphoproliferative disorders (LPD) have been observed much frequently other countries. Therefore, this article,...
Objective. Methotrexate-associated lymphoproliferative disorders (MTX-LPD) often regress spontaneously during MTX withdrawal, but the prognostic factors remain unclear. The aim of our study was to clarify clinical, histological, and genetic that predict outcomes in patients with MTX-LPD. Methods. Patients MTX-LPD diagnosed between 2000 2012 were analyzed retrospectively regarding their clinical course, site biopsy, histological typing, Epstein-Barr virus (EBV) situ hybridization...
To update and revise the diagnostic criteria for mixed connective tissue disease (MCTD) issued by Japan Research Committee of Ministry Health, Labor, Welfare (MHLW), a round table discussion experts from rheumatology, dermatology, pediatric medicine was conducted in multiple occasions.The definition MCTD, items included were generated consensus method evaluation using clinical data typical borderline cases applying to MCTD proposed 1996 2004 MHLW.To end, all committee members reached...
To determine cytokines and MHC class II alleles in Japanese patients with adult Still's disease (ASD) clarify the association between those profiles chronic articular disease.Of 35 ASD (13 men, 22 women, mean age at onset 34.0 yr), 17 (49%) had arthritis (>6 months, ASD) 18 (51%) lacked (systemic ASD). Cytokines cytokine receptors sera were measured by ELISA. Correlations of each activity or C-reactive protein (CRP) determined. examined polymerase chain reaction methods.In ASD, female gender...
Rheumatoid arthritis (RA) is a typical complex trait and the major cause of chronic inflammation worldwide. Although multiple genetic loci have been shown for their association with onset RA, they cover only part its components are largely ethnicity-specific. To identify novel factors related to predisposition prognosis RA in Japanese, we conducted large-scale genome-wide (GWA) study. We performed GWA analysis by scanning genome 1247 cases 1486 controls 277 420 single nucleotide...
Follistatin-related protein (FRP)/follistatin-like 1 (FSTL1) is a member of the follistatin family, all which share characteristic structure unit found in follistatin, called FS domain. Developmental studies have suggested that FRP regulates organ tissue formation embryos. Immunological showed modifies joint inflammation arthritic disease, and modulates allograft tolerance. However, principle physiological function currently unknown. To address this issue, we cloned four FRP-associated...
FRP physically interacts with CD14 by fluorescence‐activated cell sorting (View interaction)
ABSTRACT Filgotinib (FLG) is a Janus kinase 1 inhibitor and metabolized to an active metabolite, GS‐829845. There no report on the method for simultaneous quantification of FLG GS‐829845 in clinical samples. We developed liquid chromatography–tandem mass spectrometry determination patient plasma. were extracted from aliquot 50 μL human plasma by simple deproteinization using methanol. Chromatographic separation was performed Shim‐pack Scepter C18‐120 column with combined mobile phase water...
Evaluate tofacitinib real-world safety/effectiveness in patients with rheumatoid arthritis Japan a 3-year all-case post-marketing surveillance study. All who initiated (07/30/2013-12/03/2017) were registered Japan. Serious infections/malignancy/mortality incidence compared active after >8 mg methotrexate/week for ≥3 months received or other drugs (control: methotrexate/other disease-modifying antirheumatic drugs/immunosuppressants). Disease activity was assessed over 3 years. The adherent...
Abstract Objective To clarify the in vivo function of follistatin‐related protein (FRP)/TSC‐36/FSTL1 rheumatoid arthritis (RA), we investigated roles FRP a mouse model arthritis. Methods Arthritis was induced BALB/c mice by injecting anti–type II collagen monoclonal antibody and lipopolysaccharide. Mice were treated with daily intraperitoneal injections 20 μg recombinant FRP. Development assessed clinical score footpad swelling. Histologic examination affected paws performed on day 21 after...
Journal Article Therapeutic response of patients with adult Still’s disease to biologic agents: multicenter results in Japan Get access Rie Suematsu, Suematsu Division Rheumatology, Department Internal Medicine, Saga University School 5-1-1 Nabeshima, 849-8501, Correspondence to: e-mail: suematsu@cc.saga-u.ac.jp Search for other works by this author on: Oxford Academic Google Scholar Akihide Ohta, Ohta Adult and Gerontological Nursing, Saga, Emi Matsuura, Matsuura Faculty Kwassui Women’s...
Objective The efficacy of biologics in treating adult Still's disease (ASD) is suggested, but the information still lacking and validation insufficient. To determine several biologic agents refractory ASD Japan, a multicenter survey was performed. Method Clinical data on 16 patients who had been treated with at least 1 biological (total 24 occasions) were collected retrospectively. Results Infliximab used 9 cases, etanercept 4, tocilizumab 11. Half that initially infliximab or changed to...
Leptin is secreted by adipocytes, the placenta, and stomach. It not only controls appetite through leptin receptors in hypothalamus, it also regulates immunity. In current study, we produced leptin-deficient MRL/Mp-Fas(lpr) mice to investigate potential role of autoimmunity. C57BL/6J-ob/ob were backcrossed with mice, which develop human systemic lupus erythematosus (SLE)-like lesions. The effects deficiency on various SLE-like manifestations investigated mice. regulatory T cell population...
We evaluated the long-term (52 weeks) safety and effectiveness of iguratimod (IGU) in patients with rheumatoid arthritis (RA).This multicenter, prospective, observational study included all evaluable RA who received IGU since its market launch 2012. adverse events (AEs); drug reactions (ADRs); ADRs special interest, including liver renal dysfunctions, interstitial lung disease, gastrointestinal blood disorders, infection; change Disease Activity Score 28-C-reactive protein (DAS28-CRP) at...