A5080190386- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Systemic Sclerosis and Related Diseases
- Chronic Lymphocytic Leukemia Research
- Vasculitis and related conditions
- Immunodeficiency and Autoimmune Disorders
- Inflammatory Myopathies and Dermatomyositis
- Lymphoma Diagnosis and Treatment
- Atherosclerosis and Cardiovascular Diseases
- Autoimmune and Inflammatory Disorders Research
- Eosinophilic Disorders and Syndromes
- Cytokine Signaling Pathways and Interactions
- Otitis Media and Relapsing Polychondritis
- Cell Adhesion Molecules Research
- Genetic Associations and Epidemiology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Celiac Disease Research and Management
- Immunotherapy and Immune Responses
- Viral Infections and Immunology Research
- IgG4-Related and Inflammatory Diseases
- Inflammasome and immune disorders
- interferon and immune responses
Kyoto University
2016-2025
Kobe City Medical Center General Hospital
2020-2025
Kyoto University of Education
2021
Kyoto University Hospital
2010-2020
Hokkaido University
2016-2017
Wakayama Medical University
2017
Kumamoto University
2017
Center for Rheumatology
2013-2016
Daiichi Sankyo (United States)
2016
Tokyo Medical University
2016
Objectives. Various autoantibodies are detected in the sera of PM/DM patients. Some them specific to patients and closely associated with clinical manifestations diseases. Recently, anti-CADM-140 antibody was reported be found specifically clinically amyopathic DM (C-ADM) acute interstitial lung disease (ILD). We assessed significance then investigated autoantigen recognized by antibody. Methods. Autoantibodies were screened 192 various CTDs 21 healthy controls using immunoprecipitation...
Nakajo-Nishimura syndrome (NNS) is a disorder that segregates in an autosomal recessive fashion. Symptoms include periodic fever, skin rash, partial lipomuscular atrophy, and joint contracture. Here, we report mutation the human proteasome subunit beta type 8 gene (PSMB8) encodes immunoproteasome β5i patients with NNS. This G201V disrupts β-sheet structure, protrudes from loop interfaces β4 subunit, close proximity to catalytic threonine residue. The mutant not efficiently incorporated...
Objective Interstitial lung disease ( ILD ) accompanied by anti–melanoma differentiation–associated gene 5 (anti– MDA ‐5)–positive dermatomyositis DM is often rapidly progressive and associated with poor prognosis. Because there no established treatment, we undertook this study to prospectively evaluate the efficacy safety of a combined immunosuppressive regimen for anti– ‐5–positive patients . Methods Adult Japanese new‐onset (n = 29) were enrolled at multiple centers from 2014 2017. They...
In spontaneous inflammatory arthritis of K/BxN T cell receptor transgenic mice, the effector phase disease is provoked by binding immunoglobulins (Igs) to joint surfaces. Inflammatory cytokines are known be involved in human arthritis, particular rheumatoid although, overall, pathogenetic mechanisms affliction remain unclear. To explore analogy between model and patients, we assessed role relative importance inflammation transferring arthritogenic serum into a panel genetically deficient...
Abstract Objective Although interleukin‐17 (IL‐17)–producing γ/δ T cells were reported to play pathogenic roles in collagen‐induced arthritis (CIA), their characteristics remain unknown. The aim of this study was clarify whether or CD4+ are the predominant IL‐17–producing cells, and determine what stimulates secret IL‐17 mice with CIA. involvement SKG autoimmune patients rheumatoid (RA) also investigated. Methods affected joints CIA counted by intracellular cytokine staining during 6...
Objective Takayasu arteritis (TAK) is a systemic vasculitis affecting large arteries and branches of the aorta. Ulcerative colitis (UC) prevalent autoimmune colitis. Since TAK UC share HLA–B*52:01 IL12B as genetic determinants, since there are case reports co‐occurrence these diseases, we hypothesized that common complication TAK. We undertook this study to perform large‐scale analysis TAK, both evaluate prevalence concurrent cases identify estimate susceptibility genes shared between 2...
Systemic lupus erythematosus (SLE) is an autoimmune disease that causes multiple organ damage. Although recent genome-wide association studies (GWAS) have contributed to discovery of SLE susceptibility genes, few has been performed in Asian populations. Here, we report a GWAS for examining 891 cases and 3,384 controls multi-stage replication 1,387 28,564 Japanese subjects. Considering expression quantitative trait loci (eQTLs) implicated genetic risks diseases, integrated eQTL study into the...
Rapidly progressive interstitial lung disease (RP-ILD) with poor prognosis often accompanies anti-melanoma differentiation-associated gene 5 (MDA5)-positive DM. Combined immunosuppressive therapy, including glucocorticoids, calcineurin inhibitors and intravenous cyclophosphamide (IVCY) is reportedly effective in DM RP-ILD, but some patients remain resistant to therapy. We examined the utility of plasma exchange (PE) such intractable cases investigated prognostic factors disease.Thirty-eight...
Objective. Methotrexate-associated lymphoproliferative disorders (MTX-LPD) often regress spontaneously during MTX withdrawal, but the prognostic factors remain unclear. The aim of our study was to clarify clinical, histological, and genetic that predict outcomes in patients with MTX-LPD. Methods. Patients MTX-LPD diagnosed between 2000 2012 were analyzed retrospectively regarding their clinical course, site biopsy, histological typing, Epstein-Barr virus (EBV) situ hybridization...
To update and revise the diagnostic criteria for mixed connective tissue disease (MCTD) issued by Japan Research Committee of Ministry Health, Labor, Welfare (MHLW), a round table discussion experts from rheumatology, dermatology, pediatric medicine was conducted in multiple occasions.The definition MCTD, items included were generated consensus method evaluation using clinical data typical borderline cases applying to MCTD proposed 1996 2004 MHLW.To end, all committee members reached...
K/B×N T cell receptor transgenic mice are a model of inflammatory arthritis, most similar to rheumatoid that is critically dependent on both and B lymphocytes. Transfer serum, or just immunoglobulins, from arthritic animals into healthy recipients provokes arthritis efficiently, rapidly, with high penetrance. We have explored the genetic heterogeneity in response serum transfer, thereby focussing end-stage effector phase leap-frogging initiating events. Inbred mouse strains showed clear...
We established an experimental system in vitro to examine the developmental capacity of individual hematopoietic progenitors generate T, B and myeloid (M) cells. By using this we analyzed process lineage commitment murine fetal liver (FL). It is known that small numbers M cells, addition T are generated a co-culture deoxyguanosine-treated thymus (FT) lobe. tried enhance growth cells by IL-7, IL-3 stem cell factor into co-culture. This cytokine-supplemented FT organ culture was used FL....
Rheumatoid arthritis (RA) is a typical complex trait and the major cause of chronic inflammation worldwide. Although multiple genetic loci have been shown for their association with onset RA, they cover only part its components are largely ethnicity-specific. To identify novel factors related to predisposition prognosis RA in Japanese, we conducted large-scale genome-wide (GWA) study. We performed GWA analysis by scanning genome 1247 cases 1486 controls 277 420 single nucleotide...