A5043406641- Genetic Associations and Epidemiology
- Monoclonal and Polyclonal Antibodies Research
- Galectins and Cancer Biology
- Glycosylation and Glycoproteins Research
- Cancer Research and Treatments
- Advanced Proteomics Techniques and Applications
- Bioinformatics and Genomic Networks
- Immunotherapy and Immune Responses
- Machine Learning in Bioinformatics
- Allergic Rhinitis and Sensitization
- Cancer-related molecular mechanisms research
- CAR-T cell therapy research
- Veterinary medicine and infectious diseases
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Artificial Intelligence in Healthcare
- Cancer Cells and Metastasis
- Helicobacter pylori-related gastroenterology studies
- Immune Cell Function and Interaction
- Caveolin-1 and cellular processes
- Healthcare Systems and Public Health
- Williams Syndrome Research
- Asthma and respiratory diseases
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Mass Spectrometry Techniques and Applications
Nagoya University
2005-2008
Chiba University
2001
An anti–glypican 3/CD3 bispecific T cell–redirecting antibody (ERY974) is a promising therapeutic agent for solid tumors.
The cancer stem cell (CSC) concept has been proposed as an attractive theory to explain development, and CSCs themselves have considered targets for the development of diagnostics therapeutics. However, many unanswered questions concerning existence slow cycling/quiescent, drug-resistant remain. Here we report establishment colon CSC lines, interconversion between a proliferating state, reconstitution tumor hierarchy from CSCs. Stable lines having properties were established human after...
Abstract Here, we report for the first time a comparative phosphoproteomic analysis of distinct tumor cell lines in presence or absence microtubule‐interfering agent nocodazole. In total, 1525 phosphorylation sites assigned to 726 phosphoproteins were identified using LC‐MS‐based technology following phosphopeptide enrichment. Analysis amino acid composition surrounding vivo revealed that they could be classified into two motif groups: pSer‐Pro and pSer‐Asp/Glu. Phosphoproteomic change...
Recent studies have suggested that not only genetic factors such as single nucleotides polymorphisms (SNPs) but also environmental smoking, alcohol consumption, and intake of salty food affect the development heterogeneous diseases. Revealing may contribute to Helicobacter pylori infection a consequence specific will help in developing personalized medicine. Eighty-four H. infection-positive 84 infection-negative subjects were analyzed using data for 37 different with machine learning...
Abstract Background: ERY974 is a humanized IgG4 bispecific T cell-redirecting antibody (TRAB) currently in Phase 1 clinical trial (NCT02748837). consists of common light chain and two different heavy chains that respectively recognize glypican-3 (GPC3) CD3. The Fc portion modified to lose FcγR binding prevent GPC3-independent Fc-mediated effector function. However, activity FcRn, an important factor the PK profile IgG, maintained. simultaneously binds GPC3 on cancer cell surface CD3 surface,...
Abstract To deliver investigational drugs to appropriate patients from the early clinical development stage, it would be ideal identify biomarker candidates at preclinical stage. investigate prediction biomarkers in models, a large cell panel consisting of over 500 lines various tumor types was molecularly profiled. find their gene expression profiles, copy number variations, single nucleotide variations and fusions, we conducted comprehensive analysis with GeneChip, CGH array, exon...