A5102938236- Amyotrophic Lateral Sclerosis Research
- Monoclonal and Polyclonal Antibodies Research
- Neurogenetic and Muscular Disorders Research
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Glycosylation and Glycoproteins Research
- Cerebrovascular and Carotid Artery Diseases
- Erythrocyte Function and Pathophysiology
- Hereditary Neurological Disorders
- Intracranial Aneurysms: Treatment and Complications
- Acute Ischemic Stroke Management
- Glycogen Storage Diseases and Myoclonus
- Genetics, Aging, and Longevity in Model Organisms
- Parkinson's Disease Mechanisms and Treatments
- RNA Interference and Gene Delivery
- RNA Research and Splicing
- Phagocytosis and Immune Regulation
- Cellular transport and secretion
- Hippo pathway signaling and YAP/TAZ
- Histone Deacetylase Inhibitors Research
- Neurological diseases and metabolism
- Lysosomal Storage Disorders Research
- Cerebrovascular and genetic disorders
- Cancer-related gene regulation
Kyoto Prefectural University of Medicine
2009-2019
Chugai Pharma (United States)
2008-2018
Neurology, Inc
2014
Saint John's Health Center
2008
Kyoto first Red Cross hospital
2007
An anti–glypican 3/CD3 bispecific T cell–redirecting antibody (ERY974) is a promising therapeutic agent for solid tumors.
Mutations in the fused sarcoma/translated liposarcoma gene (FUS/TLS, FUS) have been identified sporadic and familial forms of amyotrophic lateral sclerosis (ALS). FUS is an RNA-binding protein that normally localized nucleus, but mislocalized to cytoplasm ALS, comprises cytoplasmic inclusions ALS-affected areas. However, it still unknown whether neurodegeneration occurs ALS caused by loss nuclear function, or gain toxic function due aggregation. Cabeza (Caz) a Drosophila orthologue human...
The extracellular adenosine triphosphate (ATP) concentration is highly elevated in the tumor microenvironment (TME) and remains tightly regulated normal tissues. Using phage display technology, we establish a method to identify an antibody that can bind antigen only presence of ATP. Crystallography analysis reveals ATP bound between antibody-antigen interface serves as switch for binding. In transgenic mouse model overexpressing systemically, binds tumors with minimal binding tissues plasma...
In humans, mutations in the fused sarcoma (FUS) gene have been identified sporadic and familial forms of amyotrophic lateral sclerosis (ALS).Cabeza (Caz) is Drosophila ortholog human FUS.Previously, we established models ALS harboring Caz-knockdown.These flies develop locomotive deficits anatomical defects motoneurons (MNs) at neuromuscular junctions; these phenotypes indicate that loss physiological FUS functions nucleus can cause MN degeneration similar to seen FUS-related ALS.Here, aimed...
Phosphoglycerate kinase 1 (PGK-1) is a glycolytic enzyme encoded by PGK-1, which maps to the X chromosome. PGK-1 deficiency causes X-linked recessive hereditary chronic hemolytic anemia, myopathy, and neurological disorders due insufficient ATP regeneration. Early-onset parkinsonism has occasionally been reported as complication of this condition. However, heterozygous carriers were thought be neurologically asymptomatic. Here, we report boy with his mother, carrier mutation in both whom...
A murine (mAHM) and a humanized (AHM) monoclonal antibody against CD317 (also called tetherin, BST2, or HM1.24 antigen), expressed preferentially in neoplastic B cells such as multiple myeloma, exhibited antitumor effects result of antibody-dependent cellular cytotoxicity (ADCC). The putative interferon (IFN) response elements IRF-1/2 ISGF3 are present the promoter gene, IFN has been used for treatment not only myeloproliferative diseases but also solid tumors renal cell carcinoma (RCC)...
Abstract Purpose: L612, a human IgM monoclonal antibody produced by an EBV-transformed B-cell line, binds to ganglioside GM3 and kills GM3-positive melanoma cells in the presence of complement. It has been shown be effective some patients with late-stage melanoma. L612 consists hexameric (about 20%), pentameric 74%), other minor molecules. Because activates complement more effectively than IgM, we developed evaluated hexamer-dominant recombinant for clinical applications. Experimental...
Abstract Identifying a strategy with strong efficacy against non-inflamed tumours is vital in cancer immune therapy. ERY974 humanized IgG4 bispecific T cell-redirecting antibody that recognizes glypican-3 and CD3. Here we examine the combination effect of chemotherapy (paclitaxel, cisplatin, capecitabine) treatment xenograft model. monotherapy shows minor antitumour on NCI-H446 xenografted tumours, as infiltration ERY974-redirected cells limited to tumour-stromal boundary. However, therapy...
Purpose: To report a technique for emergency CAS of stenotic internal carotid artery (ICA) lesion with an intraluminal thrombus, which predisposes to distal thromboembolism and could aggravate pre-existing neurological symptoms. Case Report: A 77-year-old man fluctuating stroke underwent successful ICA stenosis thrombus using tandem balloon protection featuring proximal blockade PercuSurge GuardWire system protection. Conclusion: This experience suggests that is potential treatment in...
A 66-year-old man was admitted for progressive proximal weakness and myalgia in his shoulder girdles without skin lesions. muscle biopsy showed infiltration of inflammatory cells, degeneration fibers, perifascicular atrophy. Remarkably, MHC-I antigen expressed the membrane most cells were CD8-positive, suggesting that class-I antigen-dependent cytotoxic T-cells played a crucial role pathology, which supported diagnosis polymyositis rather than dermatomyositis. Magnetic resonance imaging...
We report a patient with adult-type Pompe disease treated enzyme replacement therapy (ERT) for 5.5 years. evaluated pulmonary function and muscle strength using 6-minute walk test, manual dynamometer-based measurement. The long-term ERT resulted in substantial improvement the possible stabilization followed by mild deterioration power measured dynamometer test. Our data may rationalize use of terms maintaining function.
Charcot–Marie–Tooth disease (CMT) is the most common hereditary neuropathy, and more than 80 CMT-causing genes have been identified to date. CMT4J caused by a loss-of-function mutation in Factor-Induced-Gene 4 (FIG4) gene, product of which plays important roles endosome–lysosome homeostasis. We hypothesized that Mammalian sterile 20-like kinase (MST) 1 2, tumor-suppressor genes, are candidate modifiers CMT4J. therefore examined interaction between dFIG4 Hippo (hpo), Drosophila counterparts...
Fused in sarcoma (FUS) was identified as a component of typical inclusions frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). In FTLD, both nuclear cytoplasmic with wild-type FUS exist, while mutant-form occur many ALS cases. These observations imply that plays role across these two diseases. this study, we examined the effect several proteins including molecular chaperons on aberrant eye morphology phenotype induced by overexpression human (hFUS) Drosophila...