A5034662506- Anesthesia and Pain Management
- Nausea and vomiting management
- Rheumatoid Arthritis Research and Therapies
- Anesthesia and Sedative Agents
- Bone and Joint Diseases
- Spine and Intervertebral Disc Pathology
- Bone health and osteoporosis research
- Cardiac Ischemia and Reperfusion
- Bone Metabolism and Diseases
- Dental Anxiety and Anesthesia Techniques
- Foot and Ankle Surgery
- Systemic Lupus Erythematosus Research
- Pain Management and Opioid Use
- Liver Disease Diagnosis and Treatment
- Orthopaedic implants and arthroplasty
- Shoulder Injury and Treatment
- Protease and Inhibitor Mechanisms
- Pain Mechanisms and Treatments
- Apelin-related biomedical research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Pediatric Pain Management Techniques
- Chronic Lymphocytic Leukemia Research
- Anesthesia and Neurotoxicity Research
- Smart Grid Security and Resilience
- Traditional Chinese Medicine Analysis
Wenzhou Medical University
2013-2024
First Affiliated Hospital of Wenzhou Medical University
2013-2024
Electric Power Research Institute
2024
Capital Medical University
2023
Soochow University
2021
First Affiliated Hospital of Soochow University
2021
Osaka University
2000-2014
Yukioka Hospital
2014
Osaka University Hospital
2014
University of Haifa
2013
While lipid emulsion may reverse the systemic toxicity of bupivacaine, pharmacokinetics and tissue distribution bupivacaine after infusion are not clear. In this study, we assessed influence administration on bupivacaine.Rats in group were administered IV at rate 2 mg·kg(-1)·min(-1) for 4 minutes, then treated with an 30% 3 mL·kg(-1)·min(-1) 5 minutes; saline was substituted control (n = 6 pharmacokinetics). We randomly assigned 100 rats into 50 distribution). The model treatment same as...
<h3>Background and Objectives</h3> The analgesic effect duration of a transversus abdominis plane (TAP) block remain controversial. Transversus blocks are effective for somatic/incisional pain but do not provide analgesia visceral from intra-abdominal procedures. purpose this study was to assess the area extent cutaneous sensory blockade regression dermatomal anesthesia after bilateral oblique subcostal TAP block. <h3>Methods</h3> This observational, prospective clinical consisted 12 healthy...
We previously described abnormalities in the bone marrow of patients with rheumatoid arthritis (RA), but were able to shed little light on pathogenic roles inflammatory cytokines and proteinases joint destruction subchondral region RA. This is first report describe co-localization this area.Decalcified paraffin-embedded sections from 10 RA five osteoarthritis (OA) examined for immunolocalization cathepsins B, K L localization messenger RNAs interleukin 1beta (IL-1beta), tumour necrosis...
The concentration-response and time-response relationships of lipid emulsions used to reverse bupivacaine-induced asystole are poorly defined.Concentration response across a range concentrations (0-16%) were observed using isolated rat heart Langendorff preparation. Cardiac function parameters recorded during infusion. Concentrations bupivacaine in myocardial tissue measured by liquid chromatography tandem mass spectrometry at the end experiment.Although all lipid-treated hearts recovered...
Objectives: The retention of the anti-rheumatic agent tocilizumab (TCZ) has not been well documented in patients with rheumatoid arthritis (RA). We conducted an observational study to compare TCZ and anti-tumour necrosis factor (TNF) drugs treatment RA.Method: reviewed continuation rates causes discontinuation biological agents (biologics) by assessing medical records RA who were administered biologics at our institute from September 1999 April 2012, using Osaka University Biologics for...
To study the respective peripheral and systemic mechanisms of action dexmedetomidine, as adjuvant to regional anesthesia, we compared dexmedetomidine added ropivacaine for mid-forearm nerve blocks, either systemic-only a control with no dexmedetomidine.Sixty patients undergoing hand surgery were randomly divided into three groups (n = 20 per group). Each group underwent triple-nerve (median, radial ulnar) blocks 0.75% ropivacaine. In DexP group, 60 µg anesthetic mixture, while in DexIV they...
Objective . Our present study tested whether flurbiprofen axetil could reduce perioperative sufentanil consumption and provide postoperative analgesia with decrease in emergency agitation systemic proinflammatory cytokines release. Methods Ninety patients undergoing tangential excision surgery were randomly assigned to three groups: (1) preoperative dose of 100 mg a 2 μ g/kg 10 mL placebo by patient‐controlled (PCA) pump, (2) PCA (3) pump. Results Preoperative administration decreased...
Purpose: Serratus anterior plane (SAP) block is effective for analgesia after breast surgery. Whether a higher local anesthetic concentration prolongs sensory duration and improves postoperative remains unclear. The aim of this study was to compare the analgesic effects SAP with different concentrations ropivacaine. Patients Methods: Sixty patients scheduled surgery were enrolled in randomized double-blind trial. induced 20 mL 0.375%, 0.5%, or 0.75% ropivacaine Group R0.375, R0.5, R0.75,...
Objective The transmuscular quadratus lumborum (TQL) block and the oblique subcostal transversus abdominis plane (OSTAP) both contribute to multimodal analgesia after laparoscopic surgery. objective of this study was compare analgesic effects TQL versus OSTAP hysterectomy. Design Prospective single-centre randomised single-blind trial. Setting University-affiliated hospital. Participants Patients aged between 18 65 years scheduled for Interventions were into two groups (1:1 ratio) received...
BACKGROUND: Cardiotoxicity can be induced by the commonly used amide local anesthetic, bupivacaine. Bupivacaine inhibit protein kinase B (AKT) phosphorylation and activated adenosine monophosphate–activated alpha (AMPKα). It decouple mitochondrial oxidative enhance reactive oxygen species (ROS) production. Apelin enhances phosphatidylinositol 3-kinase (PI3K)/AKT AMPK/acetyl-CoA carboxylase (ACC) pathways, promotes complete fatty acid oxidation in heart, reduces release of ROS. In this study,...
Lipid infusions have been proposed to treat local anesthetic-induced cardiac toxicity. This study compared the effects of long-chain triglyceride (LCT) emulsions with those long- and medium-chain (LCT/MCT) on pharmacokinetics bupivacaine in a rat model.After administration intravenous infusion at 2 mg·kg·min for 5 minutes Sprague-Dawley (SD) rats, either Intralipid 20%, an LCT emulsion (LCT group, n = 6), or Lipovenoes LCT/MCT (LCT/MCT was infused 2mg·kg·min minutes. The concentrations total...
A larger volume of local anesthetic provides a wider range blocked sensory but carries greater risk. The purpose this trial was to compare the effect different volumes ropivacaine injected deep serratus anterior plane in patients undergoing breast surgery.In randomized double-blind trial, 60 surgery were randomly allocated R10, R20 and R30 groups (n=20), received block with 10, 20 30 mL 0.5% respectively. minutes after block, cutaneous tested by cold stimulus craniocaudal direction along...
This study aimed to investigate the analgesic effect of an ultrasound-guided anterior quadratus lumborum block (QLB) at L2 level on postoperative pain after laparoscopic gynaecological surgery.Prospective single-centre randomised double-blind trial.University-affiliated hospital.Sixty patients aged between 18 and 65 years scheduled for surgery.Before surgery, bilateral QLB was performed with 20 mL 0.375% ropivacaine injected each side in group, whereas equal amount saline administered...
It is currently unknown whether bupivacaine-induced asystole better resuscitated with lipid emulsion (LE) administered peripherally or centrally, and different LE regimens demonstrated similar effects. In this study, we compared the effects of various administration in a rat model asystole.Forty-five adult male Sprague-Dawley rats were subjected to randomly divided into 3 groups: (1) 20% was continuously via internal jugular vein (CV-infusion group); (2) tail (PV-infusion (3) as boluses...
Abstract In this controlled, randomized, double‐blind study, we compared the pharmacodynamics and pharmacokinetics of ropivacaine staged injection lidocaine in a combined lumbar plexus–sciatic nerve block. The experiment was performed two parts: study (Group r, n = 20; Group lr, 20) R, 10; LR, 10). sciatic blockade using either (1) 10 mL 2% then 0.75% lr LR) or (2) normal saline (N.S.) r R). Two kinds solutions were ‘staged’ injection. sensory onset time recovery assessed study. Arterial...
Cell communication and signal transduction rely heavily on the charge cell surface. The surface is negatively charged, with glycoproteins membrane providing a large percentage of charge. Sialic acid found outermost side glycan chains contributes to glycoprotein's negative highly expressed in tumor cells plays an important role metastasis immune escape by interacting extracellular ligands. However, specific effect changes still poorly understood. In this study, we used 9-azido sialic...
Continuous femoral nerve block (cFNB) is effective for analgesia after total knee arthroplasty (TKA). However, it not clear which low-dose regimen of ropivacaine infusion cFNB provides adequate and enables rapid recovery. The aim this study was to compare the effects different regimens on rehabilitation patients TKA.Sixty scheduled TKA were enrolled in trial. After surgery, 0.1%, 0.15%, 0.2% groups received 10 mL 6.7 5 per hour, respectively (n=20), at dose mg/h 48 h. primary endpoint time...