A5074351431- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Pain Management
- Microbial Community Ecology and Physiology
- Anesthesia and Sedative Agents
- Neuroinflammation and Neurodegeneration Mechanisms
- Medical Malpractice and Liability Issues
- Surgical Simulation and Training
- Healthcare cost, quality, practices
- Frailty in Older Adults
- Medical Imaging and Analysis
- Click Chemistry and Applications
- Neurological Disease Mechanisms and Treatments
- Simulation-Based Education in Healthcare
- Healthcare Quality and Management
- Soil and Water Nutrient Dynamics
- Intraoperative Neuromonitoring and Anesthetic Effects
- Pain Management and Treatment
- Acupuncture Treatment Research Studies
- Advanced Technologies in Various Fields
- Moyamoya disease diagnosis and treatment
- Patient Safety and Medication Errors
- Hemodynamic Monitoring and Therapy
- Anatomy and Medical Technology
Ningbo No. 2 Hospital
2019-2024
Zhengzhou University
2023
University of Chinese Academy of Sciences
2018-2022
Wenzhou Medical University
2015
First Affiliated Hospital of Wenzhou Medical University
2015
Several studies have demonstrated that neuroinflammation is the key to perioperative neurocognitive disorders (PND); however, specific mechanism postsurgery and anesthesia has not yet been fully clarified. The present study aimed at exploring effects of P2X4/NLRP3 signaling pathway in cognitive impairment after surgery. 12-14-month-old male C57BL/6 mice undergoing open tibial fracture surgery by sevoflurane were administered P2X4R inhibitor 5-BDBD or saline was intraperitoneally for 3...
Objective . Our present study tested whether flurbiprofen axetil could reduce perioperative sufentanil consumption and provide postoperative analgesia with decrease in emergency agitation systemic proinflammatory cytokines release. Methods Ninety patients undergoing tangential excision surgery were randomly assigned to three groups: (1) preoperative dose of 100 mg a 2 μ g/kg 10 mL placebo by patient‐controlled (PCA) pump, (2) PCA (3) pump. Results Preoperative administration decreased...
Patients undergoing major surgeries may experience certain cognitive decline, which is known as postoperative delirium (POD) or dysfunction (POCD). We employed integrated behavioral Z-scoring introduced by Guilloux et al. (2011) to investigate the effects of fracture fixation under anesthesia on hippocampus-dependent memory in mice.ICR mice (12-14 months) underwent stabilized tibial operation sevoflurane anesthesia. They were subjected a battery successive tests following surgery, including...
Postoperative cognitive dysfunction (POCD) is a common complication after surgery, especially in aged patients. Neuroinflammation has been closely associated with the development of POCD. While contribution pneumoperitoneum to systemic inflammation well documented, effect pneumoperitoneal pressure on neuroinflammation and postoperative function remains unclear. In this study, we showed that high-pressure promoted microglial activation hippocampus aggravated impairment mice. These results...
Objective We determined whether regional haemodynamics and perfusion index (PI) could be reliable indicators of a successful sciatic nerve block (SNB). Design Prospective observational trial. Setting A tertiary teaching hospital in China from April 2020 to August 2020. Participants assessed 79 patients for eligibility participate this study. Nine were excluded not meeting our inclusion criteria, three due missing measurements at all time points. Interventions The underwent SNB. Pulsed-wave...
Objective: To investigate the effect of sleep fragmentation on perioperative neurocognitive disorders (PND) and central neuroinflammation by simulating patterns postoperative patients with in aged mice. Methods: Thirty-two elderly ICR mice were randomly divided into four groups (n=8): normal group (C), surgery (S), fragmented (F), surgery+fragmented (D). Fragmented was conducted after internal fixation tibia fractures, cognitive function evaluated novel object recognition (NOR) fear...
In an era where patient-centred care is paramount, effectively managing and analyzing hospital complaints crucial for improving service quality patient satisfaction. This study examines to enhance management practices by differentiating between surgery-related non-surgery-related grievances. By identifying patterns in complaint types outcomes, we aim inform targeted improvement strategies that address specific concerns boost operational efficiency.
Developing proficiency in ultrasound-guided nerve block (UGNB) demands an intricate understanding of cross-sectional anatomy as well spatial reasoning, which is a big challenge for beginners. The aim this pilot study was to evaluate the feasibility virtual reality (VR)-facilitated education first performance interscalene brachial plexus blockade among novice anesthesiologists. We carried out testing hypothesis using prospective, single blind, randomized controlled trial. Twenty-one...
Objective: To investigate the applicability of modified memory sub-test syndrom kurz test (SKT-M) in middle-aged and elderly Chinese. Methods: Between March 1, 2017, October 31, at HwaMei Hospital, 132 patients receiving elective great saphenous vein high ligation stripping operation 96 their accompanying dependents, 55-75 years old, were randomly divided into SKT-M group (n=121) auditory verbal learning -huashan version (AVLT-H) (n=107) using random numeral method. The two groups underwent...
Objective To compare the effects of spinal anesthesia and general on early postoperative cognitive function in elderly patients undergoing hip replacement. Methods One hundred four both sexes, aged ≥ 60 yr, with body mass index 18.5-24.0 kg/m2, American Society Anesthesiologists physical status Ⅰ or Ⅱ, scheduled for elective unilateral replacement, were randomized into 2 groups (n = 52 each) using a random number table method: group (group G) S). Total intravenous was adopted to...
Objective To investigate the effects of stellate ganglion block(SGB)on attention and executive function in middle-aged elderly patients after surgery. Methods Middle-aged aged 55-75 years who underwent hip replacement surgery under lumbar anesthesia were randomized into a control group an SGB group.Patients received ultrasound-guided block 30 min before surgery, given no additional treatment surgery.All tested with modified version Trail Making Test-Part A(TMT-A)and Symbol Digit...