A5100449141- Congenital heart defects research
- Autophagy in Disease and Therapy
- Sperm and Testicular Function
- Natural Compounds in Disease Treatment
- Chronic Kidney Disease and Diabetes
- Reproductive Biology and Fertility
- Metabolism and Genetic Disorders
- Acute Kidney Injury Research
- Cardiac Ischemia and Reperfusion
- Renal and related cancers
- Mitochondrial Function and Pathology
- Advanced Glycation End Products research
- Metabolism, Diabetes, and Cancer
- Immunotherapy and Immune Responses
- Biomedical Research and Pathophysiology
- Neuroscience and Neuropharmacology Research
- Mesenchymal stem cell research
- CRISPR and Genetic Engineering
- Fungal Biology and Applications
- Epigenetics and DNA Methylation
- Circadian rhythm and melatonin
- Lymphoma Diagnosis and Treatment
- Pancreatic function and diabetes
- Tryptophan and brain disorders
- Autoimmune and Inflammatory Disorders Research
Zhejiang Chinese Medical University
2020-2025
Tongji University
2025
Sichuan University
2015-2024
Guangdong Medical College
2019-2024
Tsinghua University
2022-2024
Capital Medical University
2024
Tianjin Medical University
2017-2024
Henan University of Technology
2024
Zhengzhou University
2024
Shuguang Hospital
2024
Hyperglycaemia associated with myocardial oxidative stress and fibrosis is the main cause of diabetic cardiomyopathy. Empagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor has recently been reported to improve glycaemic control in patients type diabetes an insulin-independent manner. The aim this study was investigate effect empagliflozin on myocardium injury potential mechanism KK-Ay mice. Thirty mice were administered (10 mg/kg/day) by oral gavage daily for 8 weeks. After...
Ischemia-reperfusion injury (IRI) is a common cause of acute kidney (AKI). The susceptible to IRI under several clinical conditions, including hypotension, sepsis, and surgical procedures, such as partial nephrectomy transplantation. Extensive research has been conducted on the mechanism intervention strategies renal in past decades; however, complex pathophysiology IRI-induced AKI (IRI-AKI) not fully understood, there remains lack effective treatments for AKI. Renal involves processes,...
As one of the key initiators base excision repair process, uracil-DNA glycosylase (UDG) plays an important role in maintaining genomic integrity. It has been found that aberrant expression UDG is associated with a variety diseases. Thus, accurate and sensitive detection activity critical significance for biomedical research early clinical diagnosis. Here, we developed novel fluorescent sensing platform based on terminal deoxynucleotidyl transferase (TdT) T7 exonuclease (T7 Exo)-aided...
Glyphosate (GLY) induces developmental toxicity in fish, but research on the mechanism is limited. In this study, zebrafish embryos were exposed for 120 hpf to 0.7, 7, and 35 mg L-1 GLY. The results show that GLY treatment induced including premature hatching, reduced heartbeats, pericardial yolk sac oedema, swim bladder deficiency, shortened body length, which was possibly due a significantly decreased triiodothyronine (T3)/thyroxine (T4) ratio abnormal expression patterns of...
Abstract Ferroptosis, a nonapoptotic form of programmed cell death characterized by significant iron-dependent peroxidation phospholipids, is regulated cellular metabolism, redox homeostasis, and various cancer-related signaling pathways. Recently, considerable progress has been made in demonstrating the critical role lipid metabolism regulating ferroptosis, indicating potential combinational strategies for treating cancer future. In this study, we explored effects compounds ferroptosis...
Abstract Transcription factor EB (TFEB), known as a major transcriptional regulator of the autophagy-lysosomal pathway, regulates target gene expression by binding to coordinated lysosomal and regulation (CLEAR) elements. TFEB are regulated multiple links, such regulation, post-transcriptional translational-level post-translational modification (PTM), nuclear competitive regulation. Targeted has been victoriously used treatment strategy in several disease models ischemic injury, storage...
// Su-Ren Chen 1 , Ji-Xin Tang 1,2 Jin-Mei Cheng Jian Li Jin Xiao-Yu Shou-Long Deng Yan Zhang Xiu-Xia Wang and Yi-Xun Liu State key Laboratory of Stem Cell Reproductive Biology, Institute Zoology, Chinese Academy Sciences, Beijing, RP China 2 University the Correspondence to: Liu, email: Keywords : Gata4, spermatogonial stem cell, Sertoli cells, niche, chemokines, Pathology Section Received July 30, 2015 Accepted September 28, Published October 14, Abstract primary somatic cell in...
Mammalian oocytes are arrested at the prophase of first meiotic division for months and even years, depending on species. Meiotic resumption fully grown requires activation M-phase–promoting factor (MPF), which is composed Cyclin B1 cyclin-dependent kinase 1 (CDK1). It has long been believed that synthesis/accumulation its interaction with CDK1 a prerequisite MPF in oocytes. In this study, we revealed oocyte occurred absence B1. Ccnb1-null resumed meiosis extruded polar body. Without B1,...
To investigate the prevalence and associated factors of lower urinary tract symptoms suggestive benign prostatic hyperplasia (LUTS/BPH) in Chinese aging males.Data downloaded from China Health Retirement Longitudinal Study (CHARLS) was subjected to descriptive statistics followed by univariate logistic regression multivariate regression.A total 8563 participants with an overall LUTS/BPH 11.97% were enrolled. With aging, increased (p < 0.001). Men aged over 70 years suffered highest 22.70%....
Abstract Background Trigeminal neuralgia (TN) is difficult to treat due its severe pain intensity and recurring episodes, which significantly impact quality of life. Objectives We aimed assess the effectiveness electroacupuncture (EA) in alleviating TN, determine whether EA combined with low-dosage carbamazepine (CBZ) has a synergistic effect. Methods A multi-centre, randomized, 2 × factorial trial was conducted. Participants who met inclusion criteria received active or sham for 60 min,...
Mesangial cell proliferation has been identified as a mainly contributing factor to glomerulosclerosis, which is typical of diabetic nephropathy. However, the specific mechanisms and therapies remain unclear. PDK1 critical regulator proliferation, but role in nephropathy not fully illuminated. In current study, we demonstrated that triptolide (TP) ameliorated albuminuria high fat diet/STZ-induced rats. TP also suppressed increased proliferating markers Ki-67 PCNA kidney tissues. Our results...
Promotion of spermatogonial stem cell (SSC) differentiation into functional sperms under in vitro conditions is a great challenge for reproductive physiologists. In this study, we observed that melatonin (10(-7) M) supplementation significantly enhanced the cultured SSCs haploid germ cells. This was confirmed by expression sperm special protein, acrosin. The rate with 11.85 ± 0.93% which twofold higher than control. level testosterone, transcriptions luteinizing hormone receptor (LHR), and...
To investigate whether there is mitochondrial transfer in dental mesenchymal stem cells (MSCs) and its significance for the odontogenic differentiation.
Recently, Visual Autoregressive ($\mathsf{VAR}$) Models introduced a groundbreaking advancement in the field of image generation, offering scalable approach through coarse-to-fine "next-scale prediction" paradigm. However, state-of-the-art algorithm $\mathsf{VAR}$ models [Tian, Jiang, Yuan, Peng and Wang, NeurIPS 2024] takes $O(n^4)$ time, which is computationally inefficient. In this work, we analyze computational limits efficiency criteria fine-grained complexity lens. Our key contribution...