A5065026100- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Thyroid Cancer Diagnosis and Treatment
- Osteoarthritis Treatment and Mechanisms
- Virus-based gene therapy research
- Immune cells in cancer
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Silk-based biomaterials and applications
- Epigenetics and DNA Methylation
- Gut microbiota and health
- Cancer, Lipids, and Metabolism
- CAR-T cell therapy research
- Face and Expression Recognition
- Thyroid and Parathyroid Surgery
- Tendon Structure and Treatment
- Sarcoma Diagnosis and Treatment
- Circular RNAs in diseases
- Knee injuries and reconstruction techniques
- interferon and immune responses
- Cancer-related Molecular Pathways
- Lung Cancer Treatments and Mutations
- Advanced Clustering Algorithms Research
- Phytochemical and Pharmacological Studies
Yuhuangding Hospital
2016-2025
Qingdao University
2016-2025
Shandong Normal University
2023-2025
Second Affiliated Hospital of Dalian Medical University
2025
Xian Yang Central Hospital
2025
Air Force Medical University
2016-2024
Xijing Hospital
2016-2024
Linyi University
2024
Children's Hospital of Fudan University
2022-2024
Southern Medical University
2015-2023
Abstract Ferroptosis, a nonapoptotic form of programmed cell death characterized by significant iron-dependent peroxidation phospholipids, is regulated cellular metabolism, redox homeostasis, and various cancer-related signaling pathways. Recently, considerable progress has been made in demonstrating the critical role lipid metabolism regulating ferroptosis, indicating potential combinational strategies for treating cancer future. In this study, we explored effects compounds ferroptosis...
To investigate the role of methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) in clinical prognosis and cell biology renal carcinoma (RCC).A total 137 RCC tissues were evaluated by immunohistochemistry. The relationship between MTHFD2 overexpression parameters vimentin expression was assessed. Kaplan-Meier curves log-rank test applied for survival analysis according to tissues. mRNA protein examined quantitative reverse transcription PCR western blotting, respectively. determine further...
Abstract Differentiation therapy using small molecules is a promising strategy for improving the prognosis of glioblastoma (GBM). Histone acetylation plays an important role in cell fate determination. Nevertheless, whether histone specific sites determines GBM cells remains to be explored. Through screening from 349 molecule-library, we identified that deacetylase inhibitor (HDACi) MS-275 synergized with 8-CPT-cAMP was able transdifferentiate U87MG into neuron-like cells, which were...
Introduction Recent research indicated a strong link between the gut microbiota and osteoarthritis. However, complex interplay microbiota, serum metabolites, progression of osteoarthritis in affected individuals remains largely unexplored. This study aimed to investigate characteristics metabolites patients with Methods Participants either healthy knees or were enrolled categorized into control (HC) (OA) groups. Fecal blood samples collected for 16S rRNA gene sequencing, metabolomic analysis...
Multi-view graph clustering (MVGC) utilizes affinity graphs to efficiently obtain information between views. Although various excellent MVGC methods have been proposed, they still many limitations. To surmount these limitations, this work develops a novel tensor-based unified and discrete multi-view projection (TUDMPC) approach. Specifically, TUDMPC uses the L2,1-norm for feature selection reduce effects of redundancy noise. Meanwhile, differences among similar are minimized through tensor...
Mesenchymal stem cells (MSCs) and fibroblasts are two major seed for ligament tissue engineering. To understand the effects of mechanical stimulation on these to develop effective approaches cell therapy, it is necessary investigate biological various loading conditions cells. In this study, MSCs were tested compared under a novel Uniflex/Bioflex culture system that might mimic strain in tissue. The uniaxially or radially stretched with different strains (5%, 10%, 15%) at 0.1, 0.5, 1.0 Hz....
Thyroid cancer is now the most common endocrine malignancy and effect of miR-429 in development thyroid still need to be further investigated. The expression level was quantified by qPCR both clinical samples cultured cell lines. MTT, flow cytometry, migration analyses Matrigel invasion assays were conducted test proliferation, apoptosis, MiR-429 transfection Luciferase activity assay western blot detect direct on Zinc finger E-box-binding homeobox 1 (ZEB1) expression. In this study, it...
Abstract Reversing the highly immunosuppressive tumor microenvironment (TME) is essential to achieve long-term efficacy with cancer immunotherapy. Despite impressive clinical response checkpoint blockade in multiple types of cancer, only a minority patients benefit from this approach. Here, we report that oncolytic virus M1 induces immunogenic cell death and subsequently restores ability dendritic cells prime antitumor T cells. Intravenous injection disrupts immune tolerance privileged TME,...
Abstract Over the last decade, oncolytic virus (OV) therapy has shown its promising potential in tumor treatment. The fact that not every patient can benefit from it highlights importance for defining biomarkers help predict patients’ responses. As particular self-amplifying biotherapeutics, anti-tumor effects of OVs are highly dependent on host factors viral infection and replication. By using weighted gene co-expression network analysis (WGCNA), we found matrix remodeling associated 8...
Our previous study demonstrated that 45S ribosomal DNA (45S rDNA) clusters were chromosome fragile sites expressed spontaneously in Lolium. In this study, phenotypes of rDNA observed under aphidicolin (APH) incubation several plant species. Further actinomycin D (ActD) treatment showed transcriptional stress might interfere with chromatin packaging, resulting expression. These data identified as replication-dependent well transcription-dependent plants. the presence ActD, a dramatic switch...
Abstract Objectives Hypermethylation‐induced epigenetic silencing of tumour suppressor genes ( TSG s) are frequent events during carcinogenesis. Micro RNA ‐142 (miR‐142) is found to be dysregulated in cancer patients participate into growth, metastasis and angiogenesis. However, the suppressive role miR‐142 status methylation not fully understood hepatocellular carcinoma HCC ). Methods Hepatocellular tissues corresponding non‐neoplastic were collected. The expression function TGF ‐β two cell...
This study aimed to elucidate the underlying mechanisms of ameloblastoma (AM) through integrated bioinformatics analysis.We downloaded two microarrays AMs from GEO database and identified differentially expressed genes (DEGs) by analysis. The enrichment analysis DEGs was conducted characterize GO KEGG pathways. Protein-protein interaction (PPI) network hub were screened via STRING Cytoscape. CIBERSORT algorithm utilized analyze immune infiltration in AMs. We also verified diagnostic...
// Xincheng Liu 1, 2 , Huohui Ou 1 Leyang Xiang Xianghong Li Yu Huang 3 Dinghua Yang Department of Hepatobiliary Surgery, Nanfang Hospital Affiliated to Southern Medical University, Guangzhou, China The Second Shantou University College, Shantou, Laboratory Medicine, Correspondence to: Yang, email: dhyangyd@yahoo.com Huang, hy5810@yahoo.com Keywords: HCC, UHRF1, prognosis, proliferation, invasion Abbreviations: ubiquitin-like with plant homeodomain and ring finger domains, 1; hepatocellular...