A5102016425- Ovarian function and disorders
- Reproductive Biology and Fertility
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive Health and Technologies
- Sperm and Testicular Function
- Reproductive System and Pregnancy
- Ectopic Pregnancy Diagnosis and Management
- Prenatal Screening and Diagnostics
- Ovarian cancer diagnosis and treatment
- Pregnancy and preeclampsia studies
- Intraperitoneal and Appendiceal Malignancies
- Epigenetics and DNA Methylation
- Management of metastatic bone disease
- Reproductive Health and Contraception
- Endometriosis Research and Treatment
- Birth, Development, and Health
- Breastfeeding Practices and Influences
- Uterine Myomas and Treatments
- Gynecological conditions and treatments
- Infant Nutrition and Health
- Head and Neck Surgical Oncology
- DNA Repair Mechanisms
- Sepsis Diagnosis and Treatment
- Head and Neck Cancer Studies
- Sexual Differentiation and Disorders
Peking University Third Hospital
2016-2025
Peking University
2016-2025
Ministry of Education of the People's Republic of China
2018-2025
Weifang Medical University
2025
Aerospace Center Hospital
2025
National Clinical Research Center for Digestive Diseases
2019-2024
Capital Medical University
2022-2024
Beijing Obstetrics and Gynecology Hospital
2019-2024
Beijing Shijitan Hospital
2022-2024
Montefiore Medical Center
2017-2024
Polycystic ovary syndrome (PCOS) has become a major international public health concern. However, because of controversy about the diagnostic criteria and patient selection, estimates its absolute prevalence change with time vary greatly.We conducted two consecutive nationwide epidemiological surveys PCOS in representative samples reproductive-aged women China 2010 2020. Face-to-face interviews were performed by trained interviewers each survey. All participants completed questionnaire...
To explore whether intracytoplasmic sperm injection (ICSI) would increase the malformation risk in fetuses and live births compared with conventional vitro fertilization (IVF). Retrospective cohort study. Data were collected from couples who underwent IVF or ICSI January 2009 to December 2019 at Center for Reproductive Medicine of Peking University Third Hospital People's Republic China. A total 46,167 fresh transfer cycles 33,247 included. Intracytoplasmic IVF. The primary outcomes...
Abstract Background Ovarian ageing is one of the major issues that impacts female fertility. Mesenchymal stem cell (MSC)-based therapy has made impressive progress in recent years. However, efficacy and safety MSCs, as nonautologous components, remain to be further verified. Methods Two common sources umbilical cord-derived MSCs (UC-MSCs) adipose tissue-derived (AD-MSCs), were orthotopically transplanted into a mouse model ovarian evaluate their therapeutic effects. The treatment was...
Research questionDo endometrial preparation protocols affect pregnancy outcomes in overweight/obese women with a normal ovulatory cycle undergoing their first frozen-thawed embryo transfer (FET)?DesignThis retrospective cohort study analyzed 3713 who underwent FET between January 2018 and October 2023. Patients were divided into two groups based on the protocol: natural (NC) artificial (AC). Propensity score matching (PSM) was employed to match baseline characteristics at 1:1...
Patients with non-Hodgkin lymphoma (NHL) face heightened mortality and accelerated disease progression when persistently infected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This critical situation underscores the urgent need to identify risk factors establish early intervention strategies tailored this vulnerable population. The primary aim of study was investigate associated persistent SARS-CoV-2 infection in NHL patients during COVID-19 pandemic. A retrospective cohort...
Introduction Female obesity has been conclusively associated with compromised fertility, adverse pregnancy outcomes and higher risks of obstetric neonatal complications. However, it remains unclear whether the observed in IVF treatments among women are primarily due to itself or underlying pathologies such as PCOS. Studies investigating impact overweight/obesity compared normal weight PCOS have yielded inconsistent findings. Methods We retrospectively analyzed 4083 undergoing first IVF-ET...
Objective: To investigate the pregnancy outcomes after transvaginal or transabdominal fetal reduction for higher‐order multifetal pregnancies with four more fetuses. Methods: This retrospective study included 102 patients ovulation induction. The underwent in Reproductive Medical Center of Peking University Third Hospital from January 2000 to December 2020. Methods and reduction. Pregnancy different methods were assessed, including live birth rate, miscarriage preterm labor low birthweight...
Abstract Background To investigate the feasibility, and safety of 125 I seed permanent implantation for recurrent head neck carcinoma under CT-guidance. Results A retrospective study on 14 patients with cancers undergone different activities. The post-plan showed that actuarial D90 seeds ranged from 90 to 218 Gy (median, 157.5 Gy). follow-up was 3 60 months 13 months). median local control 18 (95% CI, 6.1-29.9 months), 1-, 2-, 3-, 5- year controls were 52%, 39%, respectively. survival rates...
This study analyzed the clinical outcomes of patients with elevated progesterone level on HCG day in IVF/ICSI cycles, different timing embryo transfer. A total 123 were involved this prospective randomized study. Group 1: blastocyst transfer group, 38 cases; 2: frozen–thawed group (first FET cycle), 42 3: fresh 43 cases. The basal FSH was comparable among three groups (6.7 ± 3 versus 7.0 2 6.9 2.4, p = 0.897). pregnancy rate highest 2, lowest 3, significantly difference (31.6% 38.1% 13.9%,...
Introduction Intracytoplasmic sperm injection (ICSI), originally introduced as add-on to in vitro fertilisation (IVF) for couples with severe male infertility, is current clinical practice also used mild or even unexplained infertility. However, ICSI has involved unresolved concerns regarding the selection and damage gametes health conditions of offspring, it labour intensive therefore more expensive than conventional IVF. High-quality well-powered randomised trials (RCTs) comparing IVF are...
Polycystic ovary syndrome (PCOS) women have high incidences of dyslipidemia, obesity, impaired glucose tolerance (IGT), diabetes, and insulin resistance (IR) are fragile to female infertility. Obesity dyslipidemia may be the intermediate biological mechanism for associations between metabolism dysfunction abnormal oogenesis embryogenesis. This retrospective cohort study was performed at a university-affiliated reproductive center. A total 917 PCOS aged 20 45 undergoing their first IVF/ICSI...
There is limited literature investigating the effects of body mass index (BMI) and androgen level on in vitro fertilization (IVF) outcomes with a gonadotropin-releasing hormone (GnRH)-antagonist protocol polycystic ovary syndrome (PCOS). Androgen-related variation effect IVF remains unknown.In this retrospective study, 583 infertile women PCOS who underwent using conventional GnRH-antagonist were included. Patients divided into four groups according to BMI level: overweight-...
Background A clinical diagnosis of polycystic ovary syndrome (PCOS) can be tedious with many different required tests and examinations. Furthermore, women PCOS have increased risks for several metabolic complications, which need long-term health management. Therefore, we attempted to establish an easily applicable model identify such at early stage. Objective To develop easy-to-use tool screening based on medical records from a large assisted reproductive technology (ART) center in China....
Seventeen patients with head and neck recurrent carcinoma underwent 125I seed implantation under CT or ultrasound guidance. The actuarial D90 of the seeds implanted was 90–160 Gy (median, 126 Gy). Median follow-up 10 months (range, 3–48 months). median local control time 16 months; 1- 2-year rates were 66.5% 49.9%, respectively. survival 51.3% 38.5%, respectively None experienced grade 4 toxicity. a feasible effective salvage treatment for cancers.
Abstract HFM1 (helicase for meiosis 1) is widely recognized as an ATP-dependent DNA helicase and expressed mainly in germ-line cells. a candidate gene of premature ovarian failure (POF), hence it also known POF9. However, the roles mammalian oocytes remain uncertain. To investigate functions HFM1, we established conditional knockout (cKO) mouse model. Specific Hfm1 from primordial follicle stage resulted depletion follicular reserve subfertility mice. In particular, abnormal spindle,...