A5102887807- Reproductive Biology and Fertility
- Ovarian function and disorders
- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Assisted Reproductive Technology and Twin Pregnancy
- Prenatal Screening and Diagnostics
- Pregnancy and preeclampsia studies
- Reproductive Health and Contraception
- Pluripotent Stem Cells Research
- Ovarian cancer diagnosis and treatment
- Growth Hormone and Insulin-like Growth Factors
- Ectopic Pregnancy Diagnosis and Management
- Gynecological conditions and treatments
- Renal and related cancers
- Birth, Development, and Health
- CRISPR and Genetic Engineering
- Poxvirus research and outbreaks
- Uterine Myomas and Treatments
- Genital Health and Disease
- Macrophage Migration Inhibitory Factor
- Demographic Trends and Gender Preferences
- Estrogen and related hormone effects
- Nuclear Receptors and Signaling
- Fetal and Pediatric Neurological Disorders
- Reproductive Health and Technologies
First People's Hospital of Yunnan Province
2012-2025
Kunming University of Science and Technology
2016-2024
First Affiliated Hospital of Zhengzhou University
2020-2023
National Health and Family Planning Commission
2023
Beijing Proteome Research Center
2021
Peking University
2012
Peking University Third Hospital
2012
Studies of cultured embryos have provided insights into human peri-implantation development. However, detailed knowledge lineage development as well underlying mechanisms remains obscure. Using 3D-cultured embryos, herein we report a complete cell atlas the early post-implantation lineages and decipher cellular composition gene signatures epiblast hypoblast derivatives. In addition, develop an embryo-like assembloid (E-assembloid) by assembling naive hESCs extraembryonic cells....
Polycystic ovary syndrome (PCOS) has become a major international public health concern. However, because of controversy about the diagnostic criteria and patient selection, estimates its absolute prevalence change with time vary greatly.We conducted two consecutive nationwide epidemiological surveys PCOS in representative samples reproductive-aged women China 2010 2020. Face-to-face interviews were performed by trained interviewers each survey. All participants completed questionnaire...
This study reveals the association between gene copy number variants (CNVs) and integrin expression in endometrial tissue, especially focusing on patients with repeated implantation failure unexplained infertility. The CNV expression, αVβ3 (by real-time quantitative polymerase chain reaction protein immunoblotting), related clinical indicators were investigated by analyzing samples from 48 failures 10 infertility no history of issues. results revealed presence CNVs approximately 31.04%...
In recent years, the incidence of female infertility has risen sharply, which is affected by many factors. It was recognized that reproductive tract microbes play a role in process conception. If could solve certain proportion infertility, it would certainly reduce pain and economic burden patients. The objective this study to investigate microbial community composition follicular fluid infertile patients its potential impact on infertility.Follicular from 49 primary 52 secondary collected...
Abstract Objective The objective ofthis study was to assess the association between thyroid hormone (TH) levels in follicular fluid (FF) and serum determine whether THs impact assisted reproductive technology (ART) outcomes. Methods This enrolled 299 women undergoing ART. Blood samples were drawn on day of human chorionic gonadotrophin (HCG) administrationand analysed for thyroid-stimulating (TSH), thyroxine(T4), triiodothyronine(T3),free T4 (fT4),free T3(fT3), peroxidase antibody (TPOAb)...
Abstract Progesterone elevation (PE) on the day of hCG trigger is associated with decreased pregnancy outcome in fresh cycles. Evidence for this comes from overall patient estimates that mostly ignore different ovarian responses. To compare impacts PE live birth rates (LBs) low, intermediate and high responders to explore cut-off value populations according response, we retrospectively analyzed a total 2,351 patients receiving assisted reproduction technology (ART) transfer cycles GnRH...
Abstract Ovarian hyperstimulation syndrome (OHSS) is one of the most life-threatening and potentially fatal complications associated with controlled ovarian (COH) during in vitro fertilization (IVF) treatment. Although pathogenesis OHSS remains unclear, elevated serum estradiol (E2) levels before human chorionic gonadotropin (hCG) administration are risk OHSS. The pineal hormone melatonin its receptors expressed granulosa cells have been shown to stimulate E2 production. However, effect on...
Polycystic ovary syndrome (PCOS) resulting from abnormal glucose metabolism is a relatively common and complex endocrine disorder among women in their reproductive years, However, the pathogenesis of PCOS still unclear. The purpose this study to investigate macrophage migration inhibitory factor (MIF) involvement nuclear (NF)-κB rats with PCOS. Results indicated that testosterone promoted increase levels MIF luteinizing hormone (LH) but inhibited level follicular stimulating (FSH). antibody...
Objective To assess the impact of serum luteinizing hormone (LH) levels on day initiation controlled ovarian stimulation (COS) after pituitary suppression early pregnancy loss and assisted reproductive technology (ART) outcomes. Design Retrospective cohort study. Setting University-affiliated hospital. Patients A total 9540 normogonadotrophic patients were treated with a GnRH agonist for in vitro fertilization (IVF). Based concentration LH COS day, divided into low (<1 mIU/mL,...
Abstract Background To assess the impact of luteinizing hormone level on ovulation trigger day (LHOTD) in vitro fertilization (IVF) outcomes gonadotropin-releasing (GnRH) agonist and antagonist regimens during fresh embryo transfer cycles. Methods A stepwise, progressive multivariate regression model was introduced to effect LHOTD clinical pregnancy live birth rates. Mantel‒Haenszel stratification analysis used examine association between with regimen. Results The had different distributions...
Abstract Studies of cultured embryos have provided insights into human peri-implantation development. However, detailed knowledge lineage developments as well underlying mechanisms remain obscure. Using 3D-cultured embryos, herein we report a complete cell atlas the early post-implantation lineages and decipher cellular composition gene signatures epiblast hypoblast derivatives. In addition, develop an embryo-like assembloid (E-assembloid) by assembling naive hESCs extraembryonic cells....
The trophoblast lineage differentiation represents a rate-limiting step in successful embryo implantation. Adhesion, invasion and migration processes within the are governed by several transcription factors. Among them, CDX2 is critical regulator shaping destiny of trophoblast. While its altered expression linchpin initiating implantation mice, precise influence on functionality early human remains unclear. In this study, we employed well-established stem cell (hTSC) lines with...
Abstract This study primarily aimed to investigate the prevalence of human papillomavirus (HPV) and other common pathogens sexually transmitted infections (STIs) in spermatozoa infertile men their effects on semen parameters. These included Ureaplasma urealyticum, parvum, Chlamydia trachomatis, Mycoplasma genitalium , herpes simplex virus 2, Neisseria gonorrhoeae, Enterococcus faecalis, Streptococcus agalactiae, Pseudomonas aeruginosa Staphylococcus aureus . A total 1951 couples were...
Abstract Aim To study the association in resistance to uterine artery blood flow and recurrent pregnancy loss (RPL) find its potential influencing factors. Methods A retrospective was conducted 870 RPL 237 non‐RPL patients visiting Clinic from January 2014 February 2018. All participants underwent comprehensive examinations were scanned by transvaginal Doppler ultrasonography during midluteal phase measure pulsatility index (PI), (RI) systolic/diastolic ratio (S/D) values of left right main...
Background: To explore whether endometrial receptivity is determined by osteopontin (OPN) and integrin αvβ3 expression in women with elevated serum progesterone (P) and/or oestradiol (E2) who are undergoing vitro fertilisation (IVF). Methods: According to hormone levels on the day of HCG administration, 33 infertile were divided into 3 groups: high E2, P, E2 P groups. The control group included 11 fertile, healthy women. Endometrial biopsy was performed ovulation + 7 8 for all study...
Patients with elevated circulating progesterone concentrations on the day of human chorionic gonadotropin (hCG) trigger had relatively low implantation rates during assisted reproductive treatments. In this study, we assess hypothesis that different regulate expression homeobox protein A10 (HOXA10) and its downstream genes through miRNA-135a.MicroRNA-135a (miR-135a), HOXA10, beta3-integrin (ITGβ3), empty spiracles homeobox-2 (EMX2) levels in endometrial tissues from patients were measured....