A5100697543- Natural product bioactivities and synthesis
- Gut microbiota and health
- Probiotics and Fermented Foods
- Phytochemistry and Biological Activities
- Genomics and Phylogenetic Studies
- Reproductive tract infections research
- Pharmacological Effects and Assays
- Microbial Community Ecology and Physiology
- Phytochemical Studies and Bioactivities
- Plant-Microbe Interactions and Immunity
- Research in Cotton Cultivation
- Tea Polyphenols and Effects
- ECG Monitoring and Analysis
- Receptor Mechanisms and Signaling
- Pharmacological Effects of Natural Compounds
- Epigenetics and DNA Methylation
- Angiogenesis and VEGF in Cancer
- Urinary Tract Infections Management
- Sesquiterpenes and Asteraceae Studies
- Phytoestrogen effects and research
- Traditional Chinese Medicine Analysis
- Protein Hydrolysis and Bioactive Peptides
- Ginseng Biological Effects and Applications
- Pelvic floor disorders treatments
- Wastewater Treatment and Nitrogen Removal
Capital Medical University
2020-2025
Lanzhou University Second Hospital
2014-2025
Lanzhou University
2014-2025
Capital Institute of Pediatrics
2022-2025
Gansu Provincial Center for Disease Control and Prevention
2025
Kunming University of Science and Technology
2015-2024
Beijing Friendship Hospital
2020-2024
Zhejiang University
2022-2024
Jiangsu University
2024
Affiliated Hospital of Jiangsu University
2024
We have demonstrated a simple and versatile method for generating continuously graded, bonelike calcium phosphate coating on nonwoven mat of electrospun nanofibers. A linear gradient in content could be achieved across the surface nanofiber mat. The had functional consequences with regard to stiffness biological activity. Specifically, mineral resulted scaffold further influenced activity mouse preosteoblast MC3T3 cells. This new class nanofiber-based scaffolds can potentially employed...
Despite the progress that has been made in diverse DNA-based nanodevices to situ monitor activity of DNA repair enzymes living cells, significance improving both sensitivity and specificity remained largely neglected understudied. Herein, we propose a regulatable nanodevice specifically for early evaluation cancer mediated by genomic instability. Concretely, an AND logic gate-regulated DNAzyme nanoflower was rationally designed self-assembly duplex modified with apurinic/apyrimidinic (AP)...
Biological treatment of saline wastewater is considered unfavorable due to salinity inhibition on microbial activity. In this study, intertidal wetland sediment (IWS) collected from a high environment was investigated as novel inoculation source for anaerobic pharmaceutical wastewater. Two parallel lab-scale sequencing batch reactors (AnSBR) were set up compare the organic removal potential IWS with conventional digested sludge (ADS). Under steady-state condition, reactor (R(i)) showed...
Rhizobacteria and endophytic bacteria play important roles in protecting host plants from infection by phytopathogens, which cause soil‐borne diseases severely impair plant health. Panax notoginseng is negatively affected continuous cropping becomes vulnerable to attack microbial pathogens. In the present study, culture‐independent Illumina MiSeq was used investigate root‐endophytic rhizospheric response of P. . Numbers decreased with cropping, while effects on were not statistically...
BackgroundMothers are the primary source of bacteria for newborns, but it is unclear whether mother-to-newborn transmission occurs prior to, during or after birth. Similarly, effect delivery mode on neonatal microorganisms has been focus controversy.MethodsHealthy maternal and pairs that underwent vaginal birth caesarean section were enrolled in this study. Meconium, placenta, membrane amniotic fluid samples newborns vaginal, rectal oral mothers collected. All amplified sequenced by a 16S...
Commensal gut microbiota protects the immune defense of extra-intestinal organs. Gut depletion by antibiotics can impair host antiviral responses and alter hepatitis B virus (HBV) infection outcomes. However, how modulates response in liver remains unclear. Here, mice were treated with broad-spectrum to deplete microbiota. integrity was evaluated, translocation live commensal bacteria their components into investigated. An HBV model established evaluate impairment after depletion. We found...
Leaf shape is considered to be one of the most significant agronomic traits in crop breeding. However, molecular basis underlying leaf morphogenesis cotton still largely unknown. In this study, through genetic mapping and investigation using a natural mutant cu with leaves curling upward, causal gene GHCU successfully identified as key regulator flattening. Knockout or its homolog tobacco CRISPR results abnormal shape. It further discovered that facilitates transport HD protein KNOTTED1-like...
Bamboo is an ideal material as it green, fast-growing, and easy to process. However, the low dimensional stability may limit application of bamboo due its richness in hydrophilic groups. Thus, effective environment-friendly modification needed solve aforementioned problems. This study employed high-temperature hydrothermal treatment for offer technical support further promote materials. was heated at various temperatures (120–160 °C) diverse durations (60–120 min), chemical composition,...
We have previously reported that high-alcohol-producing Klebsiella pneumoniae (HiAlc Kpn) in the gut can cause endo-alcoholic fatty liver disease. Here, we discover 91.2% of Kpn isolates from pulmonary disease samples also produce excess ethanol, which may be associated with respiratory severity. To further explore potential mechanism, a murine model is established high-dose bacteria. stimulates granular neutrophils (G0), subsequently transforming them into phagocytic (G1). HiAlc causes...
Abstract Background Bladder cancer (BLCA) represents one of the most prevalent urological malignancies worldwide. Bridging integrator 1 (BIN1), a well-characterized tumor suppressor that interacts with and inhibits oncogenic Myc transcription factors, has demonstrated crucial roles in various types. However, its specific functions underlying molecular mechanisms BLCA development progression remain poorly understood. This study aims to elucidate role BIN1 regulating cell proliferation,...
Objectives: The objective of this study is to explore the potential variations in metabolic activity across gliomas originating from distinct cortical regions, as assessed by O-(2-18F-fluoroethyl)-L-tyrosine positron emission tomography (18F-FET PET). Also, seeks elucidate whether these disparities correlate with molecular characteristics and clinical prognoses tumors. Specifically, research aims determine 18F-FET PET uptake are indicative underlying genetic or biochemical differences that...
BACKGROUND: The gut microbiota plays an important role in human health. It is essential to understand how the composition of neonates established. OBJECTIVES: To investigate nature microbial community first feces newborn infants compared with mothers’ placentae and vaginas. METHODS: One infant who was delivered via Cesarean section vaginally. Bar‐coded pyro‐sequencing 16S ribosomal RNA genes used bacterial structure each site. RESULTS: Neonatal both had similar communities, they were...
Gut microbiota composition is known to be associated with the progression of hepatitis B virus (HBV)-related liver cirrhosis in humans, outcome HBV infection mice, and seroconversion e-antigen nucleot(s)ide analog-treated patients. The dynamic alteration gut following still unknown. In this study, a hydrodynamic injection mouse model mimicking acute or chronic humans comparable virological immunological features was used. control mice analyzed at different time points using Illumina MiSeq...
Abstract High temperature (HT) is one of the most important environmental stress factors and seriously threatens plant growth, development, production. VQ motif-containing proteins are transcriptional regulators that have been reported to regulate growth developmental processes, including responses biotic abiotic stresses. However, relationships between HT not studied in depth plants. In this study, transgenic apple ( Malus domestica ) plants overexpressing protein-coding gene MdVQ37 were...