A5100325195- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
- Immune Cell Function and Interaction
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Natural product bioactivities and synthesis
- Peptidase Inhibition and Analysis
- Bladder and Urothelial Cancer Treatments
- Cancer-related Molecular Pathways
- Cancer-related gene regulation
- Renal and related cancers
- Phytochemical Studies and Bioactivities
- High Altitude and Hypoxia
- Kruppel-like factors research
- Viral-associated cancers and disorders
- Renal cell carcinoma treatment
- Computational Physics and Python Applications
- Lung Cancer Diagnosis and Treatment
- Heme Oxygenase-1 and Carbon Monoxide
- Protein Degradation and Inhibitors
- Ginseng Biological Effects and Applications
- Cancer Cells and Metastasis
- Machine Learning and Data Classification
- DNA Repair Mechanisms
Lanzhou University
2023-2025
Lanzhou University Second Hospital
2023-2025
Gansu Provincial Center for Disease Control and Prevention
2025
Nanjing Drum Tower Hospital
2024
Zhejiang University of Technology
2024
Chengdu University of Traditional Chinese Medicine
2022-2024
Fujian Normal University
2024
First Affiliated Hospital of GuangXi Medical University
2023-2024
Guangxi Medical University
2023-2024
China Pharmaceutical University
2023
Rationale: Circular RNAs (circRNAs) are a new form of noncoding that play crucial roles in various pathological processes. However, the expression profile and function circRNAs hepatic fibrosis (HF) remain largely unknown. In this study, we show novel circFBXW4 mediates HF via targeting miR-18b-3p/FBXW7 axis. Methods: We investigated circRNAs, microRNAs mRNAs stellate cells (HSCs) from progression regression mice by circRNAs-seq microarray analysis. found significantly dysregulated HF....
Abstract Ubiquitination is an important post-translational modification, which controls protein turnover by labeling malfunctional and redundant proteins for proteasomal degradation, also serves intriguing non-proteolytic regulatory functions. E3 ubiquitin ligases, whose substrate specificity determines the recognition of target ubiquitination, play crucial roles in ubiquitin–proteasome system. UbiNet 2.0 updated version database UbiNet. It contains 3332 experimentally verified E3–substrate...
One major characteristic of tumor cells is the aberrant activation epigenetic regulatory elements, which remodel transcriptome and ultimately promote cancer progression drug resistance. However, oncogenic functions mechanisms ovarian (OC) remain elusive. Here, super-enhancer (SE) elements that are aberrantly activated in OC identified it found SEs drive relative specific expression transcription factor KLF5 patients poly(ADP-ribose) polymerase inhibitor (PARPi)-resistant patients. associated...
Abstract Pancreatic adenocarcinoma (PAAD) is the most malignant cancer with a high mortality rate. Despite association of ribosomal protein L10 (RPL10) PAAD and previous reports on RPL26 ufmylation, relationship between RPL10 ufmylation development remains unexplored. Here, we report dissection ufmylating process potential roles in development. The was confirmed both pancreatic patient tissues cell lines, specific modification sites were identified verified. Phenotypically, significantly...
Abstract Background Bladder cancer (BLCA) represents one of the most prevalent urological malignancies worldwide. Bridging integrator 1 (BIN1), a well-characterized tumor suppressor that interacts with and inhibits oncogenic Myc transcription factors, has demonstrated crucial roles in various types. However, its specific functions underlying molecular mechanisms BLCA development progression remain poorly understood. This study aims to elucidate role BIN1 regulating cell proliferation,...
Abstract Background Lung cancer is the leading cause of cancer-related mortality. The alteration DNA methylation plays a major role in development lung cancer. Methylation biomarkers become possible method for diagnosis. Results We identified eleven cancer-specific markers ( CDO1, GSHR, HOXA11, HOXB4-1, HOXB4-2, HOXB4-3, HOXB4-4, LHX9, MIR196A1 , PTGER4-1, and PTGER4-2 ), which could differentiate benign malignant pulmonary nodules. levels these are significantly higher tissues. In...
Unraveling the specific organs and tissues involved in saponin synthesis, as well light regulatory mechanisms, is crucial for improving quality of artificially cultivated medicinal materials Paris plants. VII (PS VII), a high-value active ingredient, found almost all plant species. In this study, we focused on polyphylla var. yunnanensis (Franch.) Hand. - Mzt. (PPY) that PS synthesis predominantly occurs leaves increased by high intensity. This intriguing discovery has unveiled potential...
Background aimsRecently, immune escape has been considered as a factor leading to relapse of acute myeloid leukemia (AML). In our previous study, heme oxygenase 1 (HO-1) proved play an essential role in the proliferation and drug resistance AML cells. addition, recent studies by group have shown that HO-1 is involved AML. Nevertheless, specific mechanism which mediates remains unclear.MethodsIn this we found patients with overexpression had high rate recurrence. vitro, attenuated toxicity...
Background Diffuse large B-cell lymphoma (DLBCL) represents the most prevalent form of aggressive non-Hodgkin lymphoma. Despite receiving standard treatment, a subset patients undergoes refractory or recurrent cases, wherein involvement cancer stem cells (CSCs) could be significant. Methods We comprehensively characterized B cell subpopulations using single-cell RNA sequencing data from three DLBCL samples and one normal lymph tissue. The CopyKat R package was employed to assess malignancy...
This paper presents a novel and efficient method for certifying primary organs involved in secondary metabolite synthesis. As the most important Parispolyphylla var. yunnanensis (Franch.) Hand. -Mzt. (PPY), Paris saponin (PS) has variety of pharmacological activities PPY is increasing demand. study established leaf, rhizome, stem-vascular-bundle 13C6-Glucose feeding non-feeding four treatments to precisely certify saponins VII (PS VII) By combining liquid chromatography-mass spectrometry...
Circular RNAs (circRNAs) are a new type of endogenous non-coding RNA formed by covalent closed loop. CircRNAs characterized specificity, universality, conservation, and stability. They abundant in eukaryotic cells have biological regulatory roles at various transcriptional post-transcriptional levels. The upregulation circPRKCI has been observed variety tumors is directly related to the clinicopathological characteristics prognosis. More importantly, can participate tumorigenesis,...