A5100371937- Cancer-related molecular mechanisms research
- Multisensory perception and integration
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Phonetics and Phonology Research
- Plant and Fungal Species Descriptions
- Cancer, Lipids, and Metabolism
- Flowering Plant Growth and Cultivation
- Categorization, perception, and language
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Molecular Biology Techniques and Applications
- Cancer Genomics and Diagnostics
- Sleep and related disorders
- Lung Cancer Treatments and Mutations
- Plant Diversity and Evolution
- Plant Gene Expression Analysis
- Biocrusts and Microbial Ecology
- Tracheal and airway disorders
- Tumors and Oncological Cases
- Natural product bioactivities and synthesis
- Traditional Chinese Medicine Analysis
- Seed Germination and Physiology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Phytochemical compounds biological activities
China Pharmaceutical University
2022-2024
Xuzhou Medical College
2024
Peking University
2022-2024
Peking University Third Hospital
2024
First Hospital of Qinhuangdao
2024
Chengdu University of Traditional Chinese Medicine
2018-2023
Jilin Medical University
2023
Jilin University
2023
Goethe University Frankfurt
2023
European Medicines Agency
2023
Objective This study aims to establish the precise prevalence of sleep disorders among university students in Jiangsu Province. Utilizing a representative sample students, we measured their quality based on Pittsburgh Sleep Quality Index (PSQI). Our objective is quantitatively assess magnitude and identify key factors. By detailed analysis these relationships, our seeks provide actionable insights for development targeted interventions enhance within this population. Methods From October...
Background Metabolic reprogramming plays a significant role in the advancement of lung adenocarcinoma (LUAD), yet precise metabolic changes remain incompletely understood. This study aims to uncover indicators associated with progression LUAD. Methods A total 1083 subjects were recruited, including 670 LUAD, 135 benign nodules (BLN) and 278 healthy controls (HC). Gas chromatography-mass spectrometry (GC/MS) was used identify quantify plasma metabolites. Odds ratios (ORs) calculated determine...
This study examined the effects of linguistic experience on audio-visual (AV) perception non-native (L2) speech. Canadian English natives and Mandarin Chinese differing in degree exposure [long short length residence (LOR) Canada] were presented with fricatives three visually distinct places articulation: interdentals nonexistent labiodentals alveolars common both languages. Stimuli quiet a café-noise background four ways: audio only (A), visual (V), congruent AV (AVc), incongruent (AVi)....
Background: Colon adenocarcinoma (COAD) is the most common subtype of colon cancer, and cuproptosis a recently newly defined form cell death that plays an important role in development several malignant cancers. However, studies cuproptosis-related lncRNAs (CRLs) involved regulating are limited. The purpose this study to develop new prognostic CRLs signature explore its underlying biological mechanism. Methods: In study, we downloaded RNA-seq profiles, clinical data tumor mutational burden...
Cervical cancer is one of the most common malignant tumors among women in world. In clinical practice, Hedyotis diffusa has pharmacological effects treating cervical cancer, but its components are relatively complex, and mechanism still unclear. this work, potential active treatment were explored by means network pharmacology. By constructing ingredient-target network, enriching analyzing targets, we found key targets their effective (beta-Sitosterol Quercetin) that play a therapeutic role....
Background Bladder cancer is ranked the second most frequent tumor among urological malignancies. The research strived to establish a prognostic model based on endoplasmic reticulum stress (ERS)-related long non-coding RNA (lncRNA) in bladder cancer. Methods We extracted ERS-related genes from published and data Cancer Genome Atlas database. lncRNAs with significance were screened by univariate Cox regression, least absolute shrinkage selection operator regression analysis Kaplan-Meier...
By the systematical optimization on explants sterilizing, induction and multiplication of adventitious shoots, rooting seedling transplanting, high-efficient regeneration system domestication transplanting technology for red pitaya (Hylocereus polyrhizus) were established using dormant buds in spine base as primary materials.Results showed that optimal surface sterilization procedure (nodal segments with one base) was 0.2% mercuric chloride (HgCl 2 ) treatment 7 min.The appropriate medium...
Insomnia is a very common disease worldwide. It seriously affects the quality of human life and even endangers health. Traditional Chinese medicine (TCM) has unique advantages in intervention treatment insomnia. However, its underlying mechanism yet to be elucidated. This study was performed explore potential biomarkers mechanisms insomnia, TCM classical prescriptions. The gene microarray data insomnia downloaded preprocessed. Differentially expressed genes (DEGs) GO KEGG enrichment analyses...
Abstract Background Osteoarthritis is a chronic disease mainly involving the damage of articular cartilage and whole tissue, which main cause disability in elderly. To explore more effective treatment measures, this study analyzed regulatory role molecular mechanism lncRNA LINC00665 (LINC00665) chondrogenic differentiation bone marrow mesenchymal stem cells (BMSCs), providing valuable theoretical basis for pathogenesis patient osteoarthritis. Methods tissues healthy were obtained from 52...
Omphalia lapidescens Schroet. is a medicinal macrofungus in China that has shown good antitumor activity recent research. To explore the potential cytotoxic compounds from O. lapidescens, ethyl acetate soluble fraction of 95% ethanol extract with was phytochemically investigated. A new tetranorlanostane triterpenoid (1) and ergosteroid (4), together two known lanostanes (2 3) six Δ22-ergosteroids (5-10), were isolated. Notably, compound 1 possesses 24,25,26,27-tetranorlanostane carbon...
Ischemia–reperfusion injury has been proven to induce organ dysfunction and death, although the mechanism is not fully understood. Long non-coding RNAs (lncRNAs) have drawn wide attention with their important roles in gene expression of some biological processes diseases, including myocardial ischemia–reperfusion (I/R) injury. In this paper, a total 26 Sprague–Dawley (SD) rats were randomized into two groups: sham Hemorrhagic shock was induced by removing 45% estimated blood volume followed...
Background: Lung cancer has the highest mortality rate among cancers worldwide, and non-small cell lung (NSCLC) is major lethal factor. Saponins in Paris polyphylla smith exhibit antitumor activity against cancer, but their targets are not fully understood. Methods: In this study, we used differential gene analysis, lasso regression analysis support vector machine recursive feature elimination (SVM-RFE) to screen potential key genes for NSCLC by using relevant datasets from GEO database. The...
Unraveling the specific organs and tissues involved in saponin synthesis, as well light regulatory mechanisms, is crucial for improving quality of artificially cultivated medicinal materials Paris plants. VII (PS VII), a high-value active ingredient, found almost all plant species. In this study, we focused on polyphylla var. yunnanensis (Franch.) Hand. - Mzt. (PPY) that PS synthesis predominantly occurs leaves increased by high intensity. This intriguing discovery has unveiled potential...
BACKGROUND:The aim of this study was to explore a comprehensive analysis the competing endogenous (ceRNA) network lung adenocarcinoma and predict its regulatory mechanism prognosis correlation based on The Cancer Genome Atlas (TCGA) database. MATERIAL AND METHODS:The genes expression data from 535 cases 59 normal tissue were acquired downloaded TCGA database, differentially expressed messenger RNA (mRNA), long noncoding (lncRNA) microRNA (miRNA) selected primarily by "edgeR" package in R...