A5037892265- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Zebrafish Biomedical Research Applications
- Memory and Neural Mechanisms
- Cellular transport and secretion
- Immune Response and Inflammation
- Neurobiology and Insect Physiology Research
- Neurotransmitter Receptor Influence on Behavior
- Neurogenesis and neuroplasticity mechanisms
- Neurological disorders and treatments
- Adenosine and Purinergic Signaling
- Receptor Mechanisms and Signaling
- Venomous Animal Envenomation and Studies
- Photoreceptor and optogenetics research
- Sleep and Wakefulness Research
- Tryptophan and brain disorders
- Olfactory and Sensory Function Studies
- Sirtuins and Resveratrol in Medicine
- Adipose Tissue and Metabolism
- Apelin-related biomedical research
- Advanced Drug Delivery Systems
- Complement system in diseases
- Supramolecular Self-Assembly in Materials
- Sarcoidosis and Beryllium Toxicity Research
Bar-Ilan University
2015-2024
Alzheimer's Association of Israel
2019
Tel Aviv University
2017
Brain (Germany)
2017
Goodman (Japan)
2016
Toll-like receptors (TLRs) play essential roles in innate immunity and increasing evidence indicates that these are expressed neurons, astrocytes microglia the brain where they mediate responses to infection, stress injury. Very little is known about of TLRs cognition. To test hypothesis TLR4 has a role hippocampus-dependent spatial learning memory, we used mice deficient for receiving chronic antagonist infusion lateral ventricles brain. We found developmental deficiency enhances reference...
Neurogenesis, the formation of new neurons in adult brain, is important for memory and extinction. One most studied external interventions that affect rate neurogenesis physical exercise. Physical exercise promotes via several factors including brain-derived neurotrophic factor (BDNF) vascular endothelial growth (VEGF). Here, we identified L-lactate, a exercise-induced metabolite, as hippocampal neurogenesis. While prolonged exposure to L-lactate promoted neurogenesis, no beneficial effect...
Abstract Motivation: Spatial learning is one of the most widely studied cognitive domains in neuroscience. The Morris water maze and Barnes are commonly used techniques to assess spatial memory rodents. Despite fact that these tasks well-validated paradigms for testing abilities, manual categorization performance into behavioral strategies subject individual interpretation, thus bias. We have previously described an unbiased machine-learning algorithm classify maze. Results: Here, we offer a...
The assessment of spatial cognitive learning in rodents is a central approach neuroscience, as it enables one to assess and quantify the effects treatments genetic manipulations from broad perspective. Although Morris water maze (MWM) well-validated paradigm for testing abilities, manual categorization performance MWM into behavioral strategies subject individual interpretation, thus biases. Here we offer support vector machine (SVM) - based, automated, unbiased strategy classification...
Summary Objective Epilepsy affects 60 million people worldwide. Despite the development of antiepileptic drugs, up to 35% patients are drug refractory with uncontrollable seizures. Toll‐like receptors ( TLR s) central components nonspecific innate inflammatory response. Because 3 was recently implicated in neuronal plasticity, we hypothesized that it may contribute epilepsy after status epilepticus SE ). Methods To test involvement epileptogenesis, used pilocarpine model for 3‐deficient mice...
Down Syndrome (DS), the most common cause of genetic intellectual disability, is characterized by over-expression APP and DYRK1A genes, located on triplicated chromosome 21. This chromosomal abnormality leads to a cognitive decline mediated Amyloid-β (Aβ) overproduction tau hyper-phosphorylation as early age 40. In this study, we used Ts65Dn mouse model DS evaluate beneficial effect DNA vaccination against Aβ1-11 fragment, in ameliorating Aβ-related neuropathology rescue behavioral...
Sirtuins are pleiotropic NAD+ dependent histone deacetylases involved in metabolism, DNA damage repair, inflammation and stress resistance. SIRT6, a member of the sirtuin family, regulates process normal aging increases lifespan male mice over-expressing Sirt6 by 15%. Neurogenesis, formation new neurons within hippocampus adult mammals, involves several complex stages including stem cell proliferation, differentiation, migration network integration. During aging, number newly generated...
Dopamine is known to differentially modulate the impact of cortical input striatum between direct and indirect pathways basal ganglia (BG). However, role extrastriatal dopamine receptors (DRs) in BG information processing less clear. To investigate DRs, we studied their distribution function one output nuclei rodent, entopeduncular nucleus (EP). qRT-PCR indicated that all DR subtypes were expressed by EP neurons, suggesting both D1-like (D1LRs) D2-like (D2LRs) likely affect EP. Whole-cell...
Abstract Assessment of spatial learning abilities is central to behavioral neuroscience and a useful tool for animal model validation drug development. However, biases introduced by the apparatus, environment, or experimentalist represent critical challenge test validity. We have recently developed Modified Barnes Maze (MBM) task, paradigm that overcomes inherent animals in classical maze. The specific combination strategies employed mice often considered representative level cognitive...
Risperidone (RSP) is an atypical antipsychotic drug widely used to treat schizophrenia and bipolar disorder. Nanoparticles (NPs) are being developed as in vivo targeted delivery systems, which cross the blood-brain barrier improve pharmacokinetics effectiveness. Here, biodegradable proteinoids were synthesized by thermal step-growth polymerization from amino acids l-glutamic acid, l-phenylalanine l-histidine poly (l-lactic acid). Proteinoid NPs containing RSP then formed self-assembly,...
Training paradigms affecting Aplysia withdrawal reflexes cause changes in gene expression leading to long-term memory formation primary mechanoafferents that initiate withdrawal. Similar are also found the buccal ganglia control feeding behavior, raising possibility these a locus of after training paradigm feeding. Buccal mechanoafferent neurons expressed increases mRNA for transcription factor Ap C/EBP, and growth sensorin-A, within first 2 h with an inedible food. No were detected rest...
Maternal antibodies (MAbs) protect against infections in immunologically-immature neonates. Maternally transferred immunity may also be harnessed to target diseases associated with endogenous protein misfolding and aggregation, such as Alzheimer's disease (AD) AD-pathology Down syndrome (DS). While familial early-onset AD (fEOAD) is autosomal dominant mutations the APP, PSEN1,2 genes, promoting cerebral Amyloid-β (Aβ) deposition, DS features a life-long overexpression of APP DYRK1A leading...
<title>Abstract</title> Assessment of spatial learning abilities is central to behavioral neuroscience and a pillar animal model validation drug development. However, biases introduced by the apparatus, environment, or experimentalist represent critical challenge test validity. We have recently developed Modified Barnes Maze (MBM) task, paradigm that overcomes inherent animals in classical maze. The specific combination strategies employed mice often considered representative level cognitive...
Abstract Down Syndrome (DS) features a life-long overexpression of the APP and DYRK1A genes, leading to cognitive decline mediated by Amyloid-β (Aβ) overproduction tau hyper-phosphorylation. As DS can be diagnosed in utero, maternally transferred anti-Aβ antibodies might promote removal early accumulation Aβ from CNS. A DNA-vaccine expressing 1-11 was delivered wild-type female mice, followed mating with 5xFAD males, which exhibit plaque formation, similar individuals DS. Maternal...