A5048092197- Pain Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Neuroinflammation and Neurodegeneration Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Tryptophan and brain disorders
- Adipose Tissue and Metabolism
- Neuropeptides and Animal Physiology
- Stress Responses and Cortisol
- CAR-T cell therapy research
- Neurological disorders and treatments
- Immune Response and Inflammation
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Spinal Cord Injury Research
- Biochemical effects in animals
- Sleep and Wakefulness Research
- Anesthesia and Pain Management
- Pain Management and Placebo Effect
- Peripheral Neuropathies and Disorders
- Cervical and Thoracic Myelopathy
- Nuclear Receptors and Signaling
- Anesthesia and Sedative Agents
- Marine Ecology and Invasive Species
Century Therapeutics (United States)
2023-2024
Tel Aviv University
2017-2024
Assaf Harofeh Medical Center
1996-2022
Merck & Co., Inc., Rahway, NJ, USA (United States)
2018
Ben-Gurion University of the Negev
2016
National Institutes of Health
2011-2013
Institute on Aging
2009-2012
National Institute on Aging
2011-2012
University of Pennsylvania
2004-2011
Duke University Hospital
1981
Toll-like receptors (TLRs) play essential roles in innate immunity and increasing evidence indicates that these are expressed neurons, astrocytes microglia the brain where they mediate responses to infection, stress injury. Very little is known about of TLRs cognition. To test hypothesis TLR4 has a role hippocampus-dependent spatial learning memory, we used mice deficient for receiving chronic antagonist infusion lateral ventricles brain. We found developmental deficiency enhances reference...
Ceruloplasmin (Cp) is a ferroxidase involved in iron metabolism by converting Fe(2+) to Fe(3+), and regulating cellular efflux. In the ceruloplasmin knockout (CpKO) mouse, deregulation of results moderate liver spleen hemosiderosis, but impact Cp deficiency on brain neurochemistry behavior this animal model unknown. We found that contrast peripheral tissues, levels hippocampus are significantly reduced CpKO mice. Although it does not cause any discernable deficits motor function or learning...
Background: Mutations in the human α-synuclein gene lead to early-onset Parkinson's disease (PD); however, phenotypes of mutant mice vary depending upon promoter driving transgene expression. Objective: The goal this study was c
Alzheimer's disease (AD) is a chronic neurodegenerative with pathological hallmarks including the formation of extracellular aggregates amyloid-beta (Aβ) known as plaques and intracellular tau tangles. Coincident Aβ recruitment activation glial cells to plaque forming niche. In addition histological data showing niche, AD genetic studies have added growing appreciation how dysfunctional glia pathways drive neuropathology, emphasis on microglia pathways. Genomic approaches enable comparisons...
Nerve root compression induces persistent behavioral hypersensitivity and spinal glial reactivity. Viscoelastic properties of neural tissues suggest that physiologic outcomes may depend on the duration an applied nerve compression. This study evaluated time-dependent under in context pain-related outcomes. The decrease load measured by relaxation was quantified for rat cervical (C6-C8) roots situ durations 30 sec, 3 min, or 15 min (n = 6). Immediately following compression, change width...
In Brief Study Design. Behavioral and immunohistochemical analysis in rat models of persistent transient allodynia. Objectives. To examine separate cervical nerve root injuries (compression, transection) for producing behavioral hypersensitivity investigate spinal neuropeptides to understand relationships pain symptoms. Summary Background Data. Mechanical injury can be a source neck pain. Painful lumbar radiculopathy show that different ligation intensities produce differential allodynia...
7023 Background: CNTY-101 is an allogeneic, iPSC-derived anti-CD19 Chimeric Antigen Receptor NK (CAR-iNK) cell product with Allo-Evasion edits to avoid host rejection. Potential benefits of include immediate availability for treatment, repeat dosing without the need lymphodepletion, and potential improved safety over T-cell based therapies. The first-in-human Phase 1 clinical trial CNTY-101, ELiPSE-1 (NCT05336409), evaluates safety, preliminary efficacy, PK, translational biomarkers in...
Abstract Although spinal glia acquire a reactive profile in radiculopathy, glial cell proliferation remains largely unstudied. This study investigated model simulating painful disc herniation; the C7 nerve root underwent compression and chromic gut suture exposure or sham procedures. A subset of injured rats received minocycline injections prior to injury. Allodynia was assessed bromodeoxyuridine (BrdU) injected 2 hr before tissue harvest on day 1 3. Spinal phenotype identification were...